Keio University · Medicine
Professor Tomonori Okamura's research lab focuses on cardiovascular and renal physiology, particularly the role of the renin-angiotensin system in hypertension and vascular function. The lab investigates hormonal and enzymatic mechanisms underlying hypertension using animal models, such as the two-kidney, one-clip hypertensive rat, with a special emphasis on renin activity and angiotensin-converting enzyme dynamics in plasma and vascular tissues. The research also extends to epidemiological aspects of cardiovascular risk factors, including hypercholesterolemia, particularly in Japanese populations. The lab aims to bridge experimental pathophysiology with clinical cardiovascular prevention strategies.
Figures are computed from collected data and may differ slightly.
The possible role of the renin-angiotensin system in the maintenance of hypertension in two-kidney, one clip hypertensive rats was studied. Plasma renin activity rose rapidly and markedly in association with the elevation of blood pressure and then decreased gradually, although blood pressure remained high. Renin activity in the lung, aorta, and mesenteric artery also increased with the development of hypertension and then decreased in a way similar to that of plasma renin activity at the chroni
Similar to Western populations, it is recommended to provide screening for hypercholesterolaemia in Japan, especially for males, although its attributable risk for coronary disease might be small.
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