The University of Osaka · Medicine
Professor Tomotaka Sobue's research lab specializes in epidemiological studies focused on lung cancer prevention, with a strong emphasis on screening efficacy, risk factor identification, and overdiagnosis bias in low-dose CT and radiographic screening. The lab investigates histologic-specific risks associated with smoking and environmental exposures—particularly in non-smoking women—while also evaluating the long-term outcomes of screen-detected lung cancer cases. Their work contributes critical evidence to population-based screening programs and public health policy in Japan and beyond.
Figures are computed from collected data and may differ slightly.
Screening with low-dose helical CT has potential to improve screening efficacy in terms of reducing lung cancer mortality. An evaluation of efficacy using appropriate methods is urgently required.
In order to update the findings of relative risk associated with cigarette smoking for lung cancer by histologic type in Japan, the data from a population-based cohort study of 91,738 men and women were analyzed. During 1990-1999, 422 lung cancer incident cases were identified. The relative risk for all incident cases associated with current smokers versus non-smokers was 4.5 [95% confidence interval (CI): 3.0-6.8] and 4.2 (95% CI: 2.4-7.2), for men and women, respectively. When divided by histo
To assess the extent of overdiagnosis bias in lung cancer screening, clinical Stage I lung cancer cases detected by chest radiograph examination, with histologic or cytologic evidence of malignancy and not treated by surgical operation, were followed up for more than 10 years. Of 1297 screen-detected and 1297 symptom-detected cases collected from 20 institutions, 42 screen-detected and 27 symptom-detected cases satisfied the study criteria. In about half of the cases, the patients had no contrai
In order to evaluate the efficacy of lung-cancer screening, a case-control study was conducted using the data from 50 areas where population-based lung-cancer screening programmes have been operated by local municipalities. In most areas, chest X-ray examinations for all participants and sputum cytology for high-risk participants were offered annually. Case series consisted of 273 deceased lung-cancer cases. For each case, 2 to 5 controls (a total of 1,269 controls) were collected from those who
A hospital-based case-control study among non-smoking women was conducted to clarify risk factors in non-smoking females in Japan. Cases consisted of 144 non-smoking female lung cancer patients, and these were compared to 713 non-smoking female controls. The odds ratio (95% confidence interval) for use of wood or straw as cooking fuels when subjects were 30 years old was estimated as 1.77 (1.08 to 2.91). For those whose household members, other than husbands, had smoked, the odds ratio was estim
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