Keio University · Medicine
토시로 사토 교수의 연구실은 장내 줄기세포의 자기재생 및 조직형성 메커니즘을 중심으로, Lgr5를 표적으로 한 3차원 배양 시스템을 개발하여 장기형성의 기초를 규명하고 있습니다. 특히, R-spondin 기반 배양 조건에서 단일 줄기세포로부터도 기능적 장상피 구조를 유도하는 방법을 확립하며, 줄기세포의 분화 및 기능 유지 메커니즘을 규명하고자 합니다. 또한 비타민 K의 생체이용가능성에 대한 연구를 통해 MK-7의 생체내 영향을 분석하고 있습니다.
Figures are computed from collected data and may differ slightly.
Recent examples have highlighted how stem cells have the capability to initiate morphogenesis in vitro; that is, to generate complex structures in culture that closely parallel their in vivo counterparts. Lgr5, the receptor for the Wnt-agonistic R-spondins, marks stem cells in multiple adult organs of mice and humans. In R-spondin-based three-dimensional cultures, these Lgr5 stem cells can grow into ever-expanding epithelial organoids that retain their original organ identity. Single Lgr5 stem c
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We have recently shown that Lgr5 (Leucine-rich repeat-containing G protein-coupled receptor) is expressed in intestinal stem cells by an in vivo genetic lineage tracing strategy. In the past, extensive efforts have been made to establish primary small intestinal culture systems. However, no defined, reproducible and robust culture system had been developed. To establish such a system, we screened for optimal gro
We conclude that MK-4 present in food does not contribute to the vitamin K status as measured by serum vitamin K levels. MK-7, however significantly increases serum MK-7 levels and therefore may be of particular importance for extrahepatic tissues.
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