Tokyo Institute of Technology · Engineering
Professor Toshiyuki Ikoma's research lab specializes in biomaterials science, focusing on the design and characterization of bioactive porous composites for regenerative medicine. The lab investigates the relationship between 3D microstructure—particularly unidirectionally interconnected pores—and mechanical properties and tissue integration in hydroxyapatite/collagen composites. A key research direction involves surface engineering of hydroxyapatite nanocrystals for protein-responsive sensing and reversible adsorption, using techniques like QCM-D and FTIR to evaluate biointerfacial behavior. The lab also explores surface regeneration methods for reusable biosensors, emphasizing protein removal without structural or functional degradation.
Figures are computed from collected data and may differ slightly.
This study investigated the effects of the three-dimensional (3-D) pore structure of a porous hydroxyapatite/collagen (HAp/Col) composite on their mechanical properties and in vivo tissue ingrowth. The unique 3-D pore structure, comprising unidirectionally interconnected pores, was fabricated by the unidirectional growth of ice crystals by using a cooling stage and a subsequent freeze-drying process. The unidirectional pores had a spindle-shaped cross section, and their size gradually increased
The repeatability of the adsorption and removal of fibrinogen and fetal bovine serum on hydroxyapatite (HAp) nanocrystal sensors was investigated by Fourier transform infrared (FTIR) spectroscopy and quartz crystal microbalance with dissipation (QCM-D) monitoring technique. The HAp nanocrystals were coated on a gold-coated quartz sensor by electrophoretic deposition. Proteins adsorbed on the HAp sensors were removed by (i) ammonia/hydrogen peroxide mixture (APM), (ii) ultraviolet light (UV), (ii
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