Hokkaido University · Medicine
Professor Tsutomu Endo's research lab focuses on the pathophysiological mechanisms linking metabolic disorders—particularly dyslipidemia, obesity, and non-alcoholic fatty liver disease (NAFLD)—to spinal ossification disorders such as ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF). The lab investigates hormonal and lipid metabolism regulation in disease progression, using both clinical data and in vitro models to explore the roles of sex steroids like 11-ketotestosterone and lipoproteins in tissue calcification. A central theme is the intersection of endocrinology, lipid metabolism, and skeletal disorders, with translational research aimed at identifying metabolic risk factors and potential therapeutic targets.
Figures are computed from collected data and may differ slightly.
To investigate the regulation of lipid uptake into the eel oocyte in more detail, effects of 11-ketotestosterone (11-KT) and lipid transporters (lipoproteins) were determined in vitro. Ovarian explants from previtellogenic Japanese eels (Anguilla japonica) were incubated for 28 days with 11-KT and/or with very low density lipoproteins (Vldl), low density lipoproteins (Ldl), or high density lipoproteins (Hdl) purified from eel plasma. The androgen 11-KT induced notable increases in oocyte diamete
Vitamin A deficiency resulting from unbalanced dietary habits is associated with exacerbation of male early-onset OPLL.
Our findings demonstrated that obesity is a distinct feature of multilevel OLF in the thoracic spine and that the severity of OLF is associated with the degree of obesity.
Obesity and metabolic disturbances are prevalent in ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF); however, the involvement of dyslipidemia (DL) in OPLL/OLF remains uncertain. We investigated the association between dyslipidemia and OPLL/OLF using a dataset of 458 individuals receiving health screening tests, including computed tomography. Subjects were grouped according to the presence or location of OPLL/OLF: controls (no OPLL/OLF, n
Ossification of the posterior longitudinal ligament (OPLL) of the spine is a disease of unknown etiology occurring frequently in individuals with metabolic disturbances. Obesity has been suggested as a potential risk factor for the severity of OPLL. We aimed to investigate whether non-alcoholic fatty liver disease (NAFLD) is associated with OPLL severity. We assessed the severity of NAFLD by a liver-to-spleen (L/S) ratio on computed tomography (CT) scans of 85 symptomatic OPLL patients at a sing
Pioglitazone could not reduce the occurrence of cardiovascular events in patients with mild DM and previous MI.
One of the approaches to reducing the size of half-wavelength linear dipole antennas is the meander dipole antenna, where the elements form a meander line. This paper presents a formula for the relationship between the geometrical size and the resonant frequency of the meander line dipole antenna, and a calculation formula for the radiative efficiency is derived from the result. It is shown that the geometrical parameters of the meander line dipole antenna can be determined from the specified ra
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