The University of Osaka · Medicine
Professor Wataru Ando's research lab specializes in regenerative medicine and orthopedic tissue engineering, with a focus on cartilage and tendon repair using mesenchymal stem cells. The lab investigates the development and mechanical characterization of tissue-engineered constructs (TECs) derived from synovial mesenchymal stem cells, particularly emphasizing extracellular matrix formation, scaffold-free engineering, and in vivo performance in cartilage repair. The lab also explores clinical applications in rare metabolic disorders such as ochronosis, where tendon integrity is compromised by pigment deposition, and evaluates long-term outcomes of metal-on-metal hip arthroplasties in relation to metal ion release and pseudotumor formation. Their work bridges basic tissue engineering with translational orthopedic surgery, aiming to improve functional outcomes in joint and tendon repair.
Figures are computed from collected data and may differ slightly.
The purpose of this study was to characterize a tissue-engineered construct (TEC) generated with human synovial mesenchymal stem cells (MSCs). MSCs were cultured in medium with ascorbic acid 2-phosphate (Asc-2P) and were subsequently detached from the substratum. The detached cell/matrix complex spontaneously contracted to develop a basic TEC. The volume of the TEC assessed by varying initial cell density showed that it was proportional to initial cell densities up to 4 x 10(5) cells/cm(2). Asse
The present study investigated the surface structure and mechanical properties of repair cartilage generated from a tissue engineered construct (TEC) derived from synovial mesenchymal stem cells at six months post-implantation compared to those of uninjured cartilage. TEC-mediated repair tissue was cartilaginous with Safranin O staining, and had comparable macro-scale compressive properties with uninjured cartilage. However, morphological assessments revealed that the superficial zone of TEC-med
We report the case of a 67-year-old man with ochronosis who had bilateral Achilles tendon ruptures. We reconstructed the Achilles tendon using pull-out wiring for the right side and an anchoring system for the left side, and reinforced the repair site using the peroneus brevis tendon for both sides. He could walk without a cane at 3 months postoperatively. Tendon ruptures in patients with ochronosis should be treated as pathologic ruptures because histologic examination reveals that both ends of
At five years, a well-positioned large head MoM THA has a significantly lower level of metal ion release and a lower incidence of moderate to severe pseudotumour than a MoM bearing of conventional size. Cite this article: Bone Joint J 2018;100-B:1018-24.
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