Kyoto University · Medicine
Professor Yasuharu Tabara's research lab specializes in genetic and molecular epidemiology, focusing on the genetic basis of complex metabolic and cardiovascular diseases, particularly type 2 diabetes and hypertension in Japanese and other populations of Asian ancestry. The lab investigates gene-environment interactions, identifies susceptibility loci through genome-wide association studies, and explores the clinical implications of genetic variants—such as G6PD deficiency—on disease diagnosis and management. A key focus is translating genetic findings into personalized medicine approaches, including genetically informed diagnostic thresholds for conditions like diabetes.
Figures are computed from collected data and may differ slightly.
As G6PD deficiency can be clinically silent until illness strikes, we recommend investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G6PD deficiency is common. Screening with direct glucose measurements, or genetically-informed HbA1c diagnostic thresholds in people with G6PD deficiency, may be required to avoid missed or delayed diagnoses.
Type 2 diabetes susceptibility of seven candidate genes was confirmed in Japanese. Conservation of susceptible loci for type 2 diabetes was independent of ethnic background.
Hypertension is one of the most common complex genetic disorders. We have described previously 38 single nucleotide polymorphisms (SNPs) with suggestive association with hypertension in Japanese individuals. In this study we extend our previous findings by analyzing a large sample of Japanese individuals (n=14 105) for the most associated SNPs. We also conducted replication analyses in Japanese of susceptibility loci for hypertension identified recently from genome-wide association studies of Eu
Abstract Background The accumulation of advanced glycation end product (AGE) might exert deleterious effects on musculoskeletal properties. Our study aims to clarify this possible association in a large general population. Methods This study investigated a general population of 9,203 patients (mean age, 57.8 years). Skeletal muscle mass was measured by bioelectrical impedance analysis, whereas accumulation of AGEs was assessed by skin autofluorescence (SAF-AGE). The muscle strength of upper and
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