Yonsei University · Medicine
Professor Yong Bae Kim's research lab specializes in molecular oncology and cancer biology, with a focus on identifying key signaling pathways and biomarkers that influence cancer progression and treatment response. The lab investigates mechanisms underlying tumor cell survival, metastasis, and the tumor microenvironment, particularly the role of molecules such as COX-2, ILK, and PTEN in regulating cancer cell behavior. A significant emphasis is placed on understanding how phagocyte-cancer cell interactions and exosomal signaling modulate epithelial-mesenchymal transition and invasion, offering potential therapeutic insights. Additionally, the lab explores fundamental biophysical processes in materials science, particularly atomic layer deposition of high-k dielectrics, reflecting a multidisciplinary approach bridging biology and materials engineering.
Figures are computed from collected data and may differ slightly.
COX-2 overexpression can be used as a potent molecular risk factor in patients with FIGO Stage IIB SCC of the uterine cervix who are treated with radiotherapy and concurrent chemotherapy.
ClinicalTrials.gov Identifier: NCT04803266.
Integrin-linked kinase (ILK) is involved in signal transduction by integrin-mediated cell adhesion that leads to dynamic actin reorganization. Actin (de)polymerization is regulated by cofilin, the Ser(3) phosphorylation (pS(3)cofilin) of which inhibits its actin-severing activity. To determine how ILK regulates pS(3)cofilin, we examined the effects of ILK on pS(3)cofilin using normal RIE1 cells. Compared with suspended cells, fibronectin-adherent cells showed enhanced pS(3)cofilin, depending on
Apoptotic cell clearance by phagocytes is essential in tissue homeostasis. We demonstrated that conditioned medium (CM) from macrophages exposed to apoptotic cancer cells inhibits the TGFβ1-induced epithelial-mesenchymal transition (EMT), migration, and invasion of cancer cells. Apoptotic 344SQ (ApoSQ) cell-induced PPARγ activity in macrophages increased the levels of PTEN, which was secreted in exosomes. Exosomal PTEN was taken up by recipient lung cancer cells. ApoSQ-exposed CM from PTEN knock
Formation of ultrathin oxide layer in water‐based processes, resulting in hydroxyl group termination, is an essential process technology for high‐k dielectric stack formation with atomic layer chemical vapor deposition (ALCVD) layers. A silicon(100) surface treated in water vapor in the temperature range of typical ALCVD processes has been studied by high‐resolution X‐ray photoelectron spectroscopy (HRXPS) analysis. cleaned silicon (100) surface is stable in water vapor up to . From , the surfac
We report a case of aggressive 'nasal type' natural killer (NK)/T cell lymphoma initially presenting as a testicular tumor in a Korean man, which quickly took a fatal course by widespread dissemination. Histologically, the testicular mass showed a diffuse dense infiltrate of medium-sized and atypical large lymphoid cells with angiocentric and angiodestructive infiltration and areas of coagulative necrosis on hematoxylin-eosin stained sections. Immunophenotyping by immunohistochemistry yielded su
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