Yong Taik Lim

Fluorescent semiconductor nanocrystals (quantum dots [QDs]) are hypothesized to be excellent contrast agents for biomedical assays and imaging. A unique property of QDs is that their absorbance increases with increasing separation between excitation and emission wavelengths. Much of the enthusiasm for using QDs in vivo stems from this property, since photon yield should be proportional to the integral of the broadband absorption. In this study, we demonstrate that tissue scatter and absorbance c

Cancer immunotherapies that harness the body's immune system to combat tumors have received extensive attention and become mainstream strategies for treating cancer. Despite promising results, some problems remain, such as the limited patient response rate and the emergence of severe immune-related adverse effects. For most patients, the therapeutic efficacy of cancer immunotherapy is mainly limited by the immunosuppressive tumor microenvironment (TME). To overcome such obstacles in the TME, the

The development of biomaterial-based immune niches that can modulate immunosuppressive factors in tumor microenvironment (TME) will be a key technology for improving current cancer immunotherapy. Here, implantable, engineered 3D porous scaffolds are designed to generate synergistic action between myeloid-derived suppressor cell (MDSC)-depleting agents, which can accommodate the establishment of a permissive immunogenic microenvironment to counteract tumor-induced immunosuppression, and cancer va

Current cancer immunotherapy based on immune checkpoint blockade (ICB) still suffers from low response rate and systemic toxicity. To overcome the limitation, a novel therapeutic platform that can revert nonimmunogenic tumors into immunogenic phenotype is highly required. Herein, a designer scaffold loaded with both immune nanoconverters encapsulated with resiquimod (iNCVs (R848)) and doxorubicin, which provides the polarization of immunosuppressive tumor-associated macrophages (TAMs) and myeloi

Fluorescent semiconductor nanocrystals (quantum dots [QDs]) are hypothesized to be excellent contrast agents for biomedical assays and imaging. A unique property of QDs is that their absorbance increases with increasing separation between excitation and emission wavelengths. Much of the enthusiasm for using QDs in vivo stems from this property, since photon yield should be proportional to the integral of the broadband absorption. In this study, we demonstrate that tissue scatter and absorbance c

The low therapeutic efficacy of current cancer immunotherapy is related to nonimmunogenic and immunosuppressive tumor microenvironments (TMEs). To overcome these limitations, both the immune priming of antitumoral lymphocytes and the reprogramming of immunosuppressive factors in TMEs are essential. Here, we suggest a nanoemulsion (NE)-based immunotherapeutic platform that can not only modulate tumor-induced suppression but also induce an effective cell-mediated immune response for T cell prolife

The rheological behavior of intercalated polystyrene/layered silicate nanocomposites was investigated. Both storage and loss moduli increased with silicate loading at all frequencies and showed non-terminal behavior at low frequencies which is a typical behavior of non-homogeneous systems with ordered microstructures. The rheological behavior in intercalated polystyrene/layered silicate nanocomposite depends not only on the intercalation of polymers, but also on the alignment of silicate layers.

What a contrast! Agents for both magnetic resonance imaging (MRI) and near-infrared (NIR) fluorescence imaging are synthesized by encapsulating iron oxide nanoparticles and indocyanine green in a poly(lactide-co-glycolide) matrix. The migration of dendritic cells (DCs) via lymphatic drainage is monitored by real-time NIR fluorescence imaging, and the tracking of DCs into lymph nodes is achieved through noninvasive MRI (see picture). Supporting information for this article is available on the WWW

Highly uniform and dense, hexagonal noble metal nanoparticle arrays were achieved on large-area transparent glass substrates via scalable, parallel processing of block copolymer lithography. Exploring their localized surface plasmon resonance (LSPR) characteristics revealed that the Ag nanoparticle array displayed a UV-vis absorbance spectrum sufficiently narrow and intense for biosensing application. A highly-sensitive, label-free detection of prostate cancer specific antibody (anti-PSA) with s

The design and synthesis of nanoparticles mimicking the key features in size, shape, and surface molecular organization of biological objects that provide danger‐signals are essential in the formulation of effective vaccine. Here, multifaceted immunomodulatory nanoliposomes (denoted as “tumosomes”) that can turn tumors into vaccines and induce enhanced antitumor immune response are suggested. Multifaceted tumosomes are synthesized by assembling tumor cell membrane proteins as tumor‐associated an