Seoul National University · Medicine
Professor Yoon Kyung Jeon's research lab focuses on the tumor microenvironment and immune regulation in lymphomas, particularly diffuse large B-cell lymphoma (DLBCL). The lab investigates key immune cells such as tumor-associated macrophages (TAMs) and regulatory T-cells (Tregs), as well as immune checkpoint molecules like PD-1 and PD-L1, to understand their prognostic and therapeutic implications. A central theme is identifying novel immune targets—such as Pellino-1, an E3 ubiquitin ligase involved in immune signaling—for cancer immunotherapy. The lab integrates preclinical models with clinical pathology to translate basic findings into potential immunotherapeutic strategies.
Figures are computed from collected data and may differ slightly.
PD-L1 and PD-1 were expressed variably in DLBCLs by tumour cells and tumour-infiltrating immune cells and might be potential therapeutic targets using PD-1/PD-L1 blockade.
Tumor-associated macrophages (TAMs) and regulatory T-cells (Tregs) play an important role in the tumor microenvironment. Here, we investigated the prognostic implications of TAMs and Tregs in 165 diffuse large B-cell lymphomas (DLBCLs) using immunohistochemistry. Survival analysis was performed among 109 DLBCLs treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). An increase in CD68 (+) cells was related to improved overall survival (OS) (p = 0.033). By con
Pellino-1 is an E3 ubiquitin ligase acting as a critical mediator for a variety of immune receptor signaling pathways, including Toll-like receptors, interleukin-1 receptor and T-cell receptors. We recently showed that the Pellino-1-transgenic (Tg) mice developed multiple tumors with different subtypes in hematolymphoid and solid organs. However, the molecular mechanism underlying the oncogenic role of Pellino-1 in solid tumors remains unknown. Pellino-1-Tg mice developed adenocarcinoma in the l
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