Kyushu University · Biochemistry, Genetics and Molecular Biology
Professor Yoshihiro Izumi's research lab specializes in systems biology and metabolomics, focusing on lipid metabolism, extracellular vesicles (EVs), and xenobiotic metabolism in disease contexts such as cancer and liver metabolism. The lab employs advanced analytical techniques—including supercritical fluid chromatography, high-resolution mass spectrometry, and stable isotope labeling—to uncover metabolic dynamics and molecular mechanisms underlying disease progression. Key research directions include the lipidomic profiling of cancer-derived EVs, metabolic kinetics of medium-chain fatty acids, and comprehensive metabolite identification for drug safety and efficacy. The lab also contributes to clinical translational research, particularly in early detection of pancreatic cancer through endoscopic ultrasound and pathological correlation.
Figures are computed from collected data and may differ slightly.
Extracellular vesicles (EVs) are lipid bilayer nanovesicles secreted from almost all cells including cancer. Cancer-derived EVs contribute to cancer progression and malignancy via educating the surrounding normal cells. In breast cancer, epidemiological and experimental observations indicated that lipids are associated with cancer malignancy. However, lipid compositions of breast cancer EVs and their contributions to cancer progression are unexplored. In this study, we performed a widely targete
The results indicated that relative quantification data obtained at different facilities and at different times would be integrated and compared by using a reference materials shared for data normalization.
Several studies in hepatocyte cell lines reported that medium-chain fatty acids (MCFAs) with 6-12 carbons showed different metabolic properties from long-chain fatty acids (LCFAs). However, these studies reported unclear effects of different fatty acid molecules on hepatocyte metabolism. This study is aimed to capture the metabolic kinetics of MCFA assimilation in AML12 cells treated with octanoic acid (FA 8:0), decanoic acid (FA 10:0), or lauric acid (FA12:0) [LCFA; oleic acid (FA 18:1)] <i>via
Abstract Background and study aims Few studies have evaluated detection of pancreatic carcinoma in situ (PCIS). We evaluated findings of endoscopic ultrasound (EUS) and pathological features of PCIS. Patients and methods We histopathologically studied 16 patients with PCIS following EUS. Diagnostic features evaluated retrospectively included stricture of the main pancreatic duct (MPD) on EUS, presence or absence of hypoechoic areas surrounding the MPD stricture on EUS, the noncancerous part (pan
A generally applicable method to discover xenobiotic metabolites is important to safely and effectively develop xenobiotics. We propose an advanced method to detect and identify comprehensive xenobiotic metabolites using stable isotope labeling, liquid chromatography coupled with benchtop quadrupole Orbitrap high-resolution tandem mass spectrometry (LC/HRMS/MS), data mining techniques (alignment, peak picking, and paired-peaks filtering), in silico metabolism prediction, and time-dependent profi
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