Kyushu University · Medicine
요시후이로 오가와 교수의 연구실은 체지방 조직에서 분비되는 생활반응물질인 아드ิ포카이닌이 대사증후군 및 인슐린 저항성과 관련된 만성 저항성 염증 반응에 미치는 영향을 중심으로 연구를 진행하고 있습니다. 특히 비만에 의한 지방세포의 비대와 면역세포 침윤, 혈관신생 등의 변화를 통해 만성 염증 상태가 어떻게 유도되는지 메커니즘을 규명하고자 합니다. 또한 심장에서 분비되는 뇌뉴레티티드펩타이드(BNP)의 합성 및 분비 메커니즘에 대해서도 심장 구조와 기능의 관점에서 연구하고 있습니다.
Figures are computed from collected data and may differ slightly.
The adipose tissue secretes a large number of bioactive substances, adipocytokines, which may be involved in a variety of physiologic and pathologic processes. Unbalanced production of pro- and anti-inflammatory adipocytokines seen in visceral fat obesity contributes critically to the development of the metabolic syndrome. Evidence has accumulated indicating that obesity is associated with a state of chronic, low-grade inflammation, suggesting that inflammation may be a potential mechanism, wher
To study synthesis, storage, and secretion of brain natriuretic peptide (BNP) in the heart, we have measured BNP mRNA and BNP concentrations in the hearts of Wistar-Kyoto rats and also have investigated its secretion from the isolated perfused heart. The atrium expressed the BNP gene at a high level, and a considerable amount of BNP mRNA also was present in the ventricle, which corresponded to approximately 40% of the atrial BNP mRNA concentration. When tissue weight was taken into account, the
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