Yonsei University · Medicine
Professor Young Lan Kwak's research lab focuses on cardiovascular anesthesiology and myocardial protection, with a primary emphasis on understanding and mitigating ischemia/reperfusion injury in cardiac surgery. The lab investigates hemodynamic management in patients with pulmonary hypertension, particularly the hemodynamic effects of vasopressors like phenylephrine and norepinephrine. A key research direction involves the molecular mechanisms of myocardial protection, especially the role of oxidative stress, inflammasome activation, and the therapeutic potential of antioxidants such as ethyl pyruvate. The lab also employs advanced hemodynamic monitoring techniques, such as thermodilution catheterization, to assess right ventricular function during off-pump coronary artery bypass surgery.
Figures are computed from collected data and may differ slightly.
In this study the effect of phenylephrine and norepinephrine for the treatment of systemic hypotension were evaluated in patients with chronic pulmonary hypertension. When systemic hypotension (systolic arterial pressure < 100 mmHg) occurred following induction of anaesthesia, either phenylephrine or norepinephrine were infused in a random manner to raise the systolic blood pressure by 30% and 50% above baseline values. Norepinephrine decreased the ratio of pulmonary arterial pressure to syst
The displacement of beating heart for positioning during anastomosis of the graft to OM artery caused significant derangement of RV function and decrease in CO. A thermodilution catheter continuously measuring the CO and RVEF was useful to monitor the change in RV function and volume during OPCAB.
Emerging evidence indicates the pronounced role of inflammasome activation linked to reactive oxygen species (ROS) in the sterile inflammatory response triggered by ischemia/reperfusion (I/R) injury. Ethyl pyruvate (EP) is an antioxidant and conveys myocardial protection against I/R injury, while the exact mechanisms remain elusive. We aimed to investigate the effect of EP on myocardial I/R injury through mechanisms related to ROS and inflammasome regulation. The rats were randomly assigned to f
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