Seoul National University · Medicine
Professor Youngro Byun's research lab specializes in biotherapeutics and biomaterials, focusing on the development of advanced drug delivery systems and surface-modified materials for biomedical applications. Key research directions include the design of heparin-based conjugates with reduced anticoagulant activity for cancer therapy, the engineering of polymeric surfaces functionalized with heparin to prevent thrombosis, and the development of non-invasive delivery strategies for macromolecular biologics. The lab also contributes to bioinformatics by creating web-based tools for RNA structure visualization, integrating computational biology with therapeutic innovation. These interdisciplinary efforts aim to enhance drug efficacy, safety, and delivery while addressing critical challenges in chronic disease management and biomaterial biocompatibility.
Figures are computed from collected data and may differ slightly.
Visualizing RNA secondary structures and pseudoknot structures is essential to bioinformatics systems that deal with RNA structures. However, many bioinformatics systems use heterogeneous data structures and incompatible software components, so integration of software components (including a visualization component) into a system can be hindered by incompatibilities between the components of the system. This paper presents an XML web service and web application program for visualizing RNA second
Although heparin can regulate angiogenesis, tumor growth and metastasis, its clinical application, as well as that of low-molecular heparin (LMWH), for treating cancer are limited because of heparin's anticoagulant activity and risk of hemorrhages. LMWH-taurocholate conjugates (LHT7), which have low anticoagulant activity, were synthesized. The structural property of LHT was evaluated by circular dichroism and the binding affinity of LHT7 to vascular endothelial growth factor 165 (VEGF(165)) was
Macromolecular therapeutics, in particular, many biologics, is the most advancing category of drugs over conventional chemical drugs. The potency and specificity of the biologics for curing certain disease made them to be a leading compound in the pharmaceutical industry. However, due to their intrinsic nature, including high molecular weight, hydrophilicity and instability, they are difficult to be administered via non-invasive route. This is a major quest especially in biologics, as they are f
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