The University of Osaka · Biochemistry, Genetics and Molecular Biology
Professor Yukihiro Akeda's research lab focuses on bacterial pathogenesis and antimicrobial resistance, with a particular emphasis on understanding the molecular mechanisms of type III secretion systems in pathogenic bacteria such as *Salmonella enterica*. The lab investigates essential virulence factors, including ATPases like InvC, to elucidate their roles in energy transduction and pathogenicity. Additionally, the lab is actively engaged in the genetic and molecular characterization of carbapenem-resistant bacteria, especially those carrying the New Delhi metallo-β-lactamase (NDM) gene, to combat the global threat of multidrug-resistant infections. Their work bridges structural microbiology, infectious disease mechanisms, and public health microbiology.
Figures are computed from collected data and may differ slightly.
An essential component of all type III secretion systems is a highly conserved ATPase that shares significant amino acid sequence similarity to the beta subunit of the F(0)F(1) ATPases and is thought to provide the energy for the secretion process. We have performed a genetic and functional analysis of InvC, the ATPase associated with the Salmonella enterica type III secretion system encoded within its pathogenicity island 1. Through a mutagenesis analysis, we have identified amino acid residues
The bacterial enzyme New Delhi metallo-β-lactamase hydrolyzes almost all β-lactam antibiotics, including carbapenems, which are drugs of last resort for severe bacterial infections. The spread of carbapenem-resistant Enterobacteriaceae that carry the New Delhi metallo-β-lactamase gene, blaNDM, poses a serious threat to public health. In this study, we genetically characterized eight carbapenem-resistant Escherichia coli isolates from a tertiary care hospital in Yangon, Myanmar. The eight isolate
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