Hokkaido University · Medicine
Professor Yuma Ebihara's research lab specializes in surgical oncology and molecular pathology, with a focus on esophageal squamous cell carcinoma (ESCC) and gastrointestinal malignancies. The lab investigates key molecular regulators such as E2F-1 and DARPP-32 to understand their roles in tumor progression and clinical outcomes. It also pioneers innovative surgical techniques, including tele-robotic surgery using the hinotori™ surgical robot, to improve minimally invasive cancer surgery. The integration of molecular biology with advanced surgical technology defines the lab’s translational research approach.
Figures are computed from collected data and may differ slightly.
Functional end-to-end esophagojejunostomy in TLTG is safe and feasible.
The transcription factor E2F-1, a downstream regulator of the p16-cyclinD-Rb pathway, is required for cell cycle progression. Evidence shows that overexpression of E2F-1 can either promote or inhibit the development of tumors, depending on tissue or experimental conditions. However, the clinical impact of E2F-1 expression on esophageal squamous cell carcinoma (ESCC) remains unknown. To analyze E2F-1 expression in ESCC, we investigated the immunoreactivity of E2F-1 and its correlation with clinic
This is the first report to correlate DARPP-32 immunoreactivity (dopamine and cAMP-regulated phosphoprotein, M(r) 32 000) to clinicopathological status in human cancer. DARPP-32 is recognised as a neuronal protein. A recent study demonstrated that DARPP-32, and a truncated isoform t-DARPP, are overexpressed in gastric carcinoma during the process of carcinogenesis. The biological function of DARPP-32, however, is still unclear. The purpose of this study was to clarify the roles of DARPP-32 and t
The purpose of this study is to evaluate the performance of tele-robotic distal gastrectomy (tele-RDG) with lymph node dissection (LND) using a novel Japanese-made surgical robot hinotori™ (Medicaroid, Kobe, Japan) in a cadaver with a presumptive gastric cancer. The Cadaveric Anatomy and Surgical Training Laboratory (CAST-Lab.) at Hokkaido University and Kushiro City General Hospital (KCGH) are connected by a guaranteed type line (1 Gbps), and the distance between the two facilities is 250 km. A
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