The University of Osaka · Medicine
Professor Yuto Kubo's research lab focuses on translational and clinical aspects of esophageal cancer management, with a strong emphasis on improving surgical outcomes, minimizing treatment-related toxicity, and developing innovative interventions for endoscopic and perioperative care. Key research directions include mitochondrial dynamics in cancer progression—particularly the role of mtDNA copy number in epithelial-mesenchymal transition and chemoresistance—alongside strategies to mitigate nephrotoxicity during neoadjuvant chemotherapy. The lab also pioneers practical innovations in surgical techniques and training, such as optimizing fluid management, preventing instrument fogging in laparoscopy, and developing novel hemostatic peptides for upper GI endosurgery.
Figures are computed from collected data and may differ slightly.
This study showed that decreased mtDNA copy number induced EMT via modulation of MMP and DNA methylation in ESCC. Therapeutic strategies increasing mtDNA copy number and DNMT inhibitors may be effective in preventing EMT and chemosensitivity resistance.
This study showed that fluid overload at POD 1 had a negative influence on postoperative complications in patients with esophageal cancer. The fluid balance must be strictly controlled during the early postoperative management of patients undergoing esophageal cancer surgery.
The new self-assembling peptide (TDM-623) showed high hemostatic effects. TDM-623 had potential usefulness for upper gastrointestinal endoscopic surgery.
This study showed that the heating time was more than ten seconds to prevent fogging. We found that fogging occurred when the laparoscopic tip temperature was 3.5 °C lower than the abdominal cavity temperature.
We showed that intravenous magnesium premedication exerts a protective effect against renal dysfunction in esophageal cancer patients undergoing neoadjuvant chemotherapy including high-dose cisplatin. Large-scale prospective studies are needed to confirm the effect of magnesium premedication on reducing nephrotoxicity in esophageal cancer patients undergoing neoadjuvant therapy.
A bleeding animal model for surgical and endoscopic training was successfully established by bolus heparin administration.
This study suggests that TDM-623 is sufficiently stable under digestive enzyme. TDM-623 is thus expected to be a durable hemostatic material that protect wound left by endoscopic surgery.
The disposable hot pack has a strong potential as an anti-fogging and cleaning device for use during laparoscopic surgery.
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