Kyoto University · Engineering
Professor Zhenghao Chen's research lab specializes in advanced optoelectronic materials and their applications in nonlinear optics and cancer biology. The lab focuses on second-harmonic generation in semiconductor quantum well structures, particularly GaAs/AlGaAs step quantum wells, exploring novel waveguide and surface-emitting configurations for efficient frequency conversion. In parallel, the lab investigates the molecular mechanisms of TRP family genes in cancer progression and the environmental impact of metal exposure—such as cadmium—on metabolic diseases like diabetes. These interdisciplinary efforts bridge nanophotonics, materials science, and translational biomedical research.
Figures are computed from collected data and may differ slightly.
Second-harmonic generation due to intersubband transitions in GaAs/AlxGa1−xAs step quantum well structures has been studied with a tunable TEA CO2 laser. The maximum value of χ(2)(2ω) is found to be ∼9×10−7 m/V. Using a multipass or ‘‘waveguide’’ structure, a conversion efficiency of more than 3×10−4 has been obtained.
We report the first experimental evidence of second-harmonic generation due to intersubband transitions in GaAs-Ga1−xAlxAs step multiquantum wells with a waveguiding surface-emitting structure. The second-harmonic generation signal obeys wave vector conservation and propagates perpendicular to the waveguiding surface. As high as 3×10−3 power conversion efficiency has been obtained. The experimental analysis and the severalfold benefit of this novel technique have been given in detail.
Our study elucidated the possible role of TRP family genes in cancer progression and provided insights for further studies on TRP family genes as potential pan-cancer targets to develop diagnostic and therapeutic strategies.
Serum cadmium was negatively associated diabetes among the representative samples of the whole population in the United States under the normal level of serum cadmium exposure. However, there was no association between serum cadmium level and the occurrence of diabetes in the high serum cadmium exposure group. This study promoted an update of new preventative strategy targeting environment for the prevention and control of diabetes in the future.
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