The University of Tokyo · Physics and Astronomy
Professor Zicong Xu's research lab specializes in quantum-enhanced optical microscopy and sensing, with a focus on advancing molecular vibrational imaging through quantum optics techniques. The lab pioneers quantum-enhanced stimulated Raman scattering (QE-SRS) microscopy, leveraging squeezed light and balanced detection to achieve sub-shot-noise-limited sensitivity for biomedical applications. Key research directions include dual-polarization quantum detection for enhanced symmetry-sensitive vibrational spectroscopy and the development of ultra-compact, high-precision temperature sensors using CMOS technology. The lab bridges quantum optics, laser science, and biomedical imaging to push the frontiers of sensitivity and resolution in molecular diagnostics.
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Quantum-enhanced stimulated Raman scattering (QE-SRS) is a promising technique for highly sensitive molecular vibrational imaging and spectroscopy surpassing the shot noise limit. However, the previous demonstrations of QE-SRS utilized rather weak optical power which hinders from competing with the sensitivity of state-of-the-art SRS microscopy and spectroscopy using relatively high-power optical pulses. Here, we demonstrate SRS spectroscopy with quantum-enhanced balanced detection (QE-BD) schem
In this paper, we propose an approach for implementing quantum-enhanced stimulated Raman scattering (QESRS) microscopy using a dual-polarization scheme. This approach has advantages for high-power operation and enables ultrasensitive Raman detection of molecular vibrational mode symmetry. To demonstrate the feasibility and effectiveness of our technique, we present both the theoretical framework and experimental results of dual-polarization QESRS. Our technique resulted in a noticeable reduction
Quantum-enhanced stimulated Raman scattering (QE-SRS) microscopy sits at the intersection of biomedical imaging, laser microscopy, and quantum optics toward realizing sensitive molecular-vibrational imaging. This Perspective explores the current status of this emerging field, integrating viewpoints from these diverse disciplines to highlight its potential for advancing biological and medical imaging. We discuss key challenges and future directions in leveraging quantum light to push the sensitiv
This paper proposes a temperature sensor based on temperature-frequency conversion using 180 nm CMOS technology. The temperature sensor consists of a proportional-to-absolute temperature (PTAT) current generating circuit, a relaxation oscillator with oscillation frequency proportional to temperature (OSC-PTAT), a relaxation oscillator with oscillation frequency independent of temperature (OSC-CON), and a divider circuit cascaded with D flip-flops. Using BJT as the temperature sensing module, the
Squeezed light has been applied in stimulated Raman scattering (SRS) spectroscopy [1] and microscopy [2] to break the shot-noise-limited sensitivity. The sub-shot-noise sensitivity achieved in quantum-enhanced SRS (QE-SRS) systems is advantageous for uncovering weak signals and achieving faster imaging speed, which attract the attention of biomedical scientists. To break the sensitivity of state-of-the-art SRS microscopes, the applied squeezed light power in QE-SRS systems should be high enough
We demonstrate photon-number squeezing via the optical Kerr effect in a standard polarization-maintaining fiber, driven by an ultrashort 10-fs Ti:Sapphire laser with a 68 THz bandwidth. A squeezing level of −0.86 dB was directly observed, corresponding to −1.12 dB after subtracting circuit noise. To our knowledge, this is the first report of squeezing generated by such an ultrabroadband source, highlighting its potential for high-speed quantum communication and quantum-enhanced spectroscopy and
We demonstrate the experimental realization of a high-power quantum-enhanced stimulated Raman scattering (QE-SRS) microscopy. By using a 25-mW squeezed light, we achieved 1.74±0.28 dB quantum enhancement in high-speed hyperspectral SRS imaging.
The relation between the chirp parameter and the temporal and spectral phases
In recent years, quantum technology has expanded its reach across a wide range of fields. Pulsed squeezing, in particular, holds significant promise for advancing quantum-enhanced nonlinear microscopy as well as high-speed quantum computing and communication. However, the performance of pulsed squeezing using the widely adopted Ti:sapphire laser has been rarely investigated, especially in the picosecond regime. Here, we report record-level picosecond pulsed squeezing of -4.41 dB generated with a
In recent years, quantum technology has expanded its reach across a wide range of fields. Pulsed squeezing, in particular, holds significant promise for advancing quantum-enhanced nonlinear microscopy as well as high-speed quantum computing and communication. However, the performance of pulsed squeezing using the widely adopted Ti:sapphire laser has been rarely investigated, especially in the picosecond regime. Here, we report record-level picosecond pulsed squeezing of -4.41 dB generated with a
We demonstrate the experimental realization of a high-power quantum-enhanced stimulated Raman scattering (QE-SRS) microscopy. By using a 25-mW squeezed light, we achieved 1.74±0.28 dB quantum enhancement in high-speed hyperspectral SRS imaging.
The relation between the chirp parameter and the temporal and spectral phases
We propose a method to measure the temporal phase of ultrashort pulsed squeezed vacuum. We verified that the temporal chirp has limited influence on pulsed squeezing level.
Benefitting from the sub-Poissonian statistics, squeezed light has been applied to push the shot-noise-limited sensitivity of stimulated Raman scattering spectroscopy and microscopy to a sub-shot-noise level [5]. However, the balanced detection regime requires a high squeezing level to counteract the 3-dB signal-to-noise ratio (SNR) drawback. In this presentation, we introduce dual-polarization quantum-enhanced stimulated Raman scattering (QESRS), which is also suitable for high-power operation
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