Kyushu University · Medicine
Professor Zulvikar Syambani Ulhaq's research lab focuses on the molecular and genetic mechanisms underlying neurodevelopmental and neurodegenerative disorders, with a particular emphasis on the roles of neuroactive hormones like estrogen and inflammatory cytokines such as IL-6 and IL-10 in brain and ocular health. The lab investigates gene-environment interactions, including the impact of P450 aromatase isoforms on serotonergic neuron development and the association of genetic polymorphisms with diseases such as Parkinson’s disease, Treacher Collins syndrome, and primary open-angle glaucoma. Their work integrates molecular biology, genetics, and clinical data to explore genotype-phenotype correlations and inflammatory pathways in neurological and ophthalmic conditions.
Figures are computed from collected data and may differ slightly.
Teleost fish are known to express two isoforms of P450 aromatase, a key enzyme for estrogen synthesis. One of the isoforms, brain aromatase (AroB), <i>cyp19a1b</i>, is highly expressed during early development of zebrafish, thereby suggesting its role in brain development. On the other hand, early development of serotonergic neuron, one of the major monoamine neurons, is considered to play an important role in neurogenesis. Therefore, in this study, we investigated the role of AroB in developmen
Interleukin-6 (IL-6) is one of the key regulators behind the inflammatory and pathological process associated with ophthalmic diseases. The role of IL-6-174 G/C polymorphism as well as intraocular IL-6 levels among various eye disease patients differ across studies and has not been systematically reviewed. Thus, this study aims to provide a summary to understand the relationship between IL-6 and ophthalmic disease. In total, 8,252 and 11,014 subjects for IL-6-174 G/C and intraocular levels of IL
Treacher Collins syndrome (TCS, OMIM: 154500) is a rare congenital craniofacial disorder that is caused by variants in the genes TCOF1, POLR1D, POLR1C, and POLR1B. Studies on the association between phenotypic variability and their relative variants are very limited. This systematic review summarized the 53 literatures from PubMed and Scopus to explore the potential TCS genotype-phenotype correlations with statistical analysis. Studies reporting both complete molecular genetics and clinical data
Anxiety symptoms and disorders are common problems associated with ophthalmic disease patients. Thus, comprehensive and appropriate treatments are necessary for treating anxiety symptoms and disorders among ophthalmic disease patients.
Abstract Background Strong evidence supports the involvement of inflammation processes in the development and progression of Parkinson’s disease (PD), where increasingly correlations have been identified between genetic variations in inflammation-related genes and PD. However, data varies between studies. Therefore, we conducted a meta-analysis to clarify associations between inflammation-related gene polymorphisms and PD risk. Methods All studies were identified through online databases. Pooled
The balance between IL-6 and IL-10 serum levels is potentially useful in discriminating POAG severity.
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