探索全球顶尖大学的研究室——研究领域与主要论文一览无余。
Professor Haruo Kasai's research lab focuses on the cellular and molecular mechanisms underlying synaptic plasticity, particularly the structural dynamics of dendritic spines in the context of learning and memory. The lab investigates how synaptic strength is regulated through activity-dependent spine enlargement and shrinkage, with a strong emphasis on the roles of dopamine signaling, protein synthesis, and cytoskeletal remodeling via actin. Using advanced imaging techniques such as two-photon microscopy and optogenetics, the lab explores the temporal precision of synaptic modification and the intrinsic mechanisms that govern spine stability and plasticity. Their work bridges cellular neuroscience with systems-level cognition, aiming to uncover the physical basis of memory formation.
Professor Su Jong Yu's research lab specializes in hepatocellular carcinoma (HCC) and hepatitis B virus (HBV)-related liver diseases, focusing on clinical management, prognostic factors, and therapeutic strategies. The lab investigates the impact of viral load, serum lipid profiles, and treatment response in HCC patients, with particular emphasis on high-risk populations such as those with resolved HBV infection or portal vein tumor thrombosis. Their work integrates large-scale retrospective studies and systematic appraisals of international guidelines to improve standard-of-care and identify novel prognostic markers and treatment approaches.
Professor Seyun Kim's research lab focuses on cellular signaling and metabolism, with a central emphasis on inositol phosphates, intermediate filaments, and autophagy regulation. The lab investigates the multifaceted roles of signaling molecules such as inositol pyrophosphates and IPMK in controlling cellular homeostasis, cell survival, and disease pathways. It also explores the structural and functional regulation of signaling proteins like betaPix and mTORC1, with translational applications in cancer therapy and metabolic disorders. The lab integrates biochemistry, cell biology, and computational drug discovery to uncover novel therapeutic targets.
Professor Hye Jin Yoo's research lab focuses on the pathophysiological roles of adipokines, hepatokines, and other metabolic hormones in the development of cardiovascular disease and metabolic syndrome. The lab investigates how adipose tissue and liver-derived signaling molecules—such as omentin-1, chemerin, fibroblast growth factor 21, fetuin-A, and selenoprotein P—influence arterial stiffness, endothelial dysfunction, and atherosclerosis, particularly in the context of type 2 diabetes and non-alcoholic fatty liver disease. Their work emphasizes the translational potential of these biomarkers as independent risk predictors and therapeutic targets. The lab integrates clinical epidemiology with molecular mechanisms to uncover novel pathways linking metabolic dysfunction to cardiovascular outcomes.
Professor Jaewoo Kang's research lab specializes in natural language processing and machine learning with a focus on biomedical and healthcare applications. The lab develops advanced deep learning models for tasks such as biomedical text mining, drug-drug interaction extraction, and schema matching in heterogeneous data sources. A key emphasis is on creating robust, generalizable models that can handle complex, noisy, or opaque biomedical data without relying on hand-crafted features. The lab also contributes to open science by releasing pre-trained models and code to support reproducibility and broader research impact.
Professor Takashi Tsuboi's research lab specializes in functional neurosurgery and movement disorders, with a primary focus on deep brain stimulation (DBS) for Parkinson’s disease, dystonia, and essential tremor. The lab investigates the clinical and neurophysiological mechanisms underlying DBS outcomes, including motor and non-motor symptoms, stimulation-induced side effects, and optimal targeting strategies using advanced imaging and connectivity analyses. Their work integrates clinical neurology with neurosurgical innovation to improve patient outcomes and quality of life.
Professor Junyoung Park's research lab specializes in intelligent systems and hardware-software co-design, focusing on energy-efficient computing, real-time scheduling, and embedded AI acceleration. The lab develops advanced algorithms and architectures—such as graph neural networks, reinforcement learning, and specialized processors—for optimizing performance in resource-constrained environments like mobile and edge devices. Key research directions include low-power vision systems, real-time task scheduling in multi-agent and multi-core environments, and secure, reliable compilation for emerging execution platforms like WebAssembly. The lab bridges theoretical innovation with practical implementation, targeting applications in autonomous systems, IoT, and embedded AI.
Professor Aloysius Soon's research lab specializes in computational materials science, focusing on the atomic-scale understanding of functional oxides and heterogeneous catalysts for energy and environmental applications. The lab employs first-principles density-functional theory (DFT) calculations to investigate surface chemistry, defect structures, and electronic properties of copper-based oxides, transition metal nitrides, and chalcogenides such as ZnIn2S4. Key research directions include the thermodynamic stability of low-index surfaces, native defects in cuprous oxide, and the design of single-atom catalysts on non-conventional supports like TiN. The work aims to guide the rational development of efficient catalysts for reactions such as the water-gas shift and methanol oxidation, with a strong emphasis on stoichiometry, metastability, and electronic structure control.
Professor Yeon Hee Park's research lab specializes in translational breast cancer genomics, focusing on understanding the molecular and immune dynamics of treatment response and resistance in HER2-positive and triple-negative breast cancers. The lab integrates multi-omics approaches—such as whole exome sequencing, transcriptome profiling, and immunohistochemistry—across longitudinal patient cohorts to identify predictive biomarkers and therapeutic vulnerabilities. Key research directions include the impact of neoadjuvant chemotherapy on the tumor immune microenvironment, the clinical relevance of tumor mutational burden in metastatic disease, and the development of targeted therapies for treatment-experienced patients. The lab also actively contributes to clinical trial design and biomarker discovery in precision oncology.
Professor Shinobu Itoh's research lab at Osaka City University specializes in bioinorganic chemistry, focusing on the mechanisms of copper-containing enzymes and model complexes involved in oxygen activation and C–H bond functionalization. The lab investigates reactive intermediates such as peroxo, hydroperoxo, and high-valent dicopper species, particularly in monooxygenase systems like tyrosinase and dopamine β-monooxygenase. Their work combines synthetic model compounds with detailed spectroscopic and kinetic studies to elucidate the role of proton-coupled electron transfer (PCET) and O–O bond cleavage in catalytic oxidation processes. The lab also explores the reactivity of high-valent copper-oxo species in biomimetic oxidation reactions and the design of efficient oxidation catalysts.
Professor Jeong-Hoon Lee's research lab specializes in hepatocellular carcinoma (HCC) biology, transplantation oncology, and immunotherapy, with a strong focus on improving prognostic models and developing novel immunotherapeutic strategies for HCC. The lab integrates clinical oncology with advanced technologies such as artificial intelligence and deep learning to refine liver transplantation criteria and predict tumor recurrence. Key research directions include the development of immune cell therapies—such as dendritic cell and cytokine-induced killer (CIK) cell vaccines—and the identification of molecular targets, including the NLRP3 inflammasome, for inflammatory diseases like acne. The lab also investigates cerebrovascular diseases, particularly posterior circulation ischemic stroke, in the Korean population, emphasizing epidemiological and clinical characterization.
Professor Young Seok Ju's research lab specializes in cancer genomics and mitochondrial biology, focusing on the identification and functional characterization of somatic mutations in both nuclear and mitochondrial DNA across various cancers. The lab employs advanced genomics technologies—such as whole-genome and whole-transcriptome sequencing—to uncover the molecular mechanisms underlying tumorigenesis, particularly in lung cancer and rare cancer subtypes. A key focus is understanding the origins and consequences of mitochondrial DNA mutations, including mitochondrial-nuclear genome fusions, and their roles in cancer progression and pathogenesis. The lab also develops computational tools, like Mutalisk, to decode mutational signatures in the context of genomic, transcriptional, and epigenomic landscapes.
Professor Mayeen Uddin Khandaker's research lab focuses on advanced materials for sustainable energy and environmental safety, with a strong emphasis on perovskite solar cells, green synthesis of nanomaterials, and radiation shielding in construction materials. The lab investigates structural and fabrication innovations to enhance the stability and efficiency of perovskite solar cells, while also exploring eco-friendly nanoparticle synthesis using biological agents for biomedical and environmental applications. Additionally, the lab conducts critical studies on radionuclide concentrations and radiation shielding properties of building materials, particularly in the context of Bangladesh’s rapid urbanization and industrial growth. These interdisciplinary efforts aim to address energy sustainability, environmental protection, and public health safety through materials science and radiation physics.
Professor Joonseok Lee's research lab specializes in the design and application of advanced nanomaterials for biomedical and environmental technologies. Key research directions include the development of graphene-based nanocomposites for enhanced photocatalysis and chemiluminescence sensing, peptide-based self-assembled nanostructures with tunable optical and surface properties, and multifunctional nanotheranostic platforms for image-guided cancer therapy. The lab also focuses on innovative nanomaterials for real-time detection of airborne pathogens, emphasizing point-of-care diagnostics and environmental monitoring.
Professor Peihao Geng's research lab specializes in advanced solid-state welding and surface engineering, with a focus on friction welding processes such as linear friction welding (LFW), inertia friction welding, and friction spot joining. The lab investigates the coupled thermo-mechanical behavior, microstructural evolution, and plastic flow dynamics in dissimilar and similar metal joints, particularly involving Ni-based superalloys, Al alloys, and metal-polymer systems. By integrating three-dimensional finite element modeling with experimental validation, the lab aims to optimize welding parameters for enhanced joint integrity and performance in aerospace and high-performance engineering applications.
Professor Yongsok Seo's research lab specializes in the design and development of advanced functional materials, with a focus on nanocomposites, piezoelectric and electroactive materials, and smart soft matter. The lab investigates the integration of nanomaterials—such as multiwalled carbon nanotubes, PZT nanofibers, and block copolymers—into polymer matrices to enhance electrical, mechanical, and rheological properties. Key research directions include energy harvesting via piezoelectric nanogenerators, tunable electrorheological and magnetorheological fluids, and interfacial self-assembly of block copolymers at liquid interfaces. The lab combines advanced fabrication techniques like electrospinning and in-situ polymerization with comprehensive characterization to enable next-generation smart materials for biomedical, energy, and industrial applications.
Professor Young-Seuk Park's research lab focuses on ecological and environmental sustainability, with a strong emphasis on biodiversity conservation, species distribution modeling under climate change, and the impacts of human development on aquatic and forest ecosystems. The lab employs advanced ecological modeling techniques—such as MaxEnt—to predict the distribution of invasive and endemic species, particularly in East Asian river systems and monsoon-affected regions. Research also extends to physiological ecology, examining ion transport mechanisms in amphibians and their responses to environmental stressors. The lab’s work bridges fundamental biological research with practical conservation strategies in the face of global environmental change.
Professor Kwan Woo Nam's research lab specializes in the design and development of advanced functional materials for sustainable energy storage, with a primary focus on aqueous rechargeable metal-ion batteries, including zinc and magnesium batteries. The lab explores innovative strategies to enhance electrochemical performance by leveraging crystal water and tailored host structures to improve ion diffusion, structural stability, and interfacial kinetics. Key research directions include the rational design of metal-organic frameworks, layered oxide cathodes, and redox-active organic materials for high-capacity, long-life, and safe energy storage systems.
Professor Keiichiro Toda's research lab specializes in developing advanced label-free optical microscopy techniques for quantitative, molecular-level analysis of biological and functional materials. The lab focuses on quantitative phase and vibrational microscopy, particularly mid-infrared photothermal and photothermal-induced refractive index imaging, to enable high-sensitivity, non-invasive detection of thermal, structural, and chemical properties at the single-cell level. A key research direction involves overcoming the sensitivity limits of conventional quantitative phase imaging through innovative temporal and differential imaging strategies, such as mid-infrared photothermal QPI and ViP-induced Soret (ViPS) microscopy. The lab also investigates thermal transport properties in biological systems using laser-based thermometry, aiming to resolve discrepancies between label-free and fluorescent thermometry methods.
Professor Hiroyuki Mizuguchi's research lab specializes in viral vector development and genome engineering, with a focus on improving adenovirus-based gene delivery systems for stem cell research and regenerative medicine. The lab develops advanced adenoviral vectors to enhance gene transduction efficiency in pluripotent stem cells, including embryonic and induced pluripotent stem cells, and applies these tools to optimize hepatic differentiation and precise genome editing. Key innovations include novel in vitro ligation systems for vector construction and strategies to boost biallelic homologous recombination in human stem cells using RAD51 overexpression and small molecules. The lab’s work bridges gene therapy, stem cell biology, and regenerative medicine through cutting-edge virology and molecular engineering.
