探索全球顶尖大学的研究室——研究领域与主要论文一览无余。
Professor Toyoshi Yanagihara's research lab focuses on the immunological and molecular mechanisms underlying interstitial lung diseases, particularly idiopathic pulmonary fibrosis (IPF) and immune checkpoint inhibitor (ICI)-induced lung injury. The lab investigates key cellular and signaling pathways—such as amphiregulin, TGF-β1, and immune checkpoint molecules—involved in epithelial cell apoptosis, fibrotic remodeling, and immune cell dysregulation. Utilizing advanced techniques like mass cytometry, ex vivo lung slices, and patient-derived samples, the lab aims to identify novel therapeutic targets and improve preclinical models for drug development. Their work bridges translational immunology with precision medicine in fibrotic and inflammatory lung disorders.
Professor Ju-Hoon Lee's research lab specializes in microbial genomics and biotechnology, with a focus on bifidobacteria and bacteriophages. The lab investigates the genetic and molecular mechanisms underlying probiotic functions of bifidobacteria, including their adaptation to the gut environment and host-microbe interactions. A key research direction involves the development of bacteriophages as novel biocontrol agents and natural food preservatives to combat foodborne pathogens such as *E. coli*, *Salmonella*, and *Listeria*. The lab also explores plasmid biology and phage-host interactions to advance applications in food safety and probiotic therapeutics.
Professor Eun-Jung Yang's research lab specializes in advancing the safety and efficacy of soft tissue filler injections and facial rejuvenation procedures. Her work focuses on vascular anatomy mapping using Doppler ultrasound to prevent life-threatening complications such as skin necrosis and blindness during cosmetic interventions. The lab emphasizes real-time vascular visualization and safe injection techniques—particularly using cannulas in the preperiosteal layer and around high-risk areas like the nose and glabella. Her research also extends to thread lifting, where vascular structures are identified to minimize procedural risks.
Professor SeongMin Kim's research lab specializes in advanced energy conversion and functional materials, focusing on triboelectric nanogenerators (TENGs) for biomedical and environmental applications. The lab develops bioadhesive and highly tribopositive materials to enhance energy harvesting and tissue repair, while also exploring ferroelectric and piezoelectric effects in hybrid heterostructures for next-generation optoelectronic and photovoltaic devices. Innovative approaches in first-principles calculations and dielectric engineering are employed to optimize material performance at the nanoscale.
Professor Sun-Mi Lee's research lab specializes in metabolic engineering and synthetic biology, focusing on enhancing microbial platforms for sustainable biofuel and biochemical production. The lab develops advanced strain engineering strategies—particularly involving xylose utilization pathways and stress tolerance mechanisms—to improve the efficiency of yeast and bacterial systems in converting lignocellulosic biomass into ethanol, lipids, and solvents like butanol. Key research directions include optimizing metabolic pathways (e.g., xylose isomerase), overcoming inhibitor challenges in biomass hydrolysates, and engineering transporters for improved cellular fitness and productivity. The lab's work bridges synthetic biology, systems microbiology, and industrial biotechnology to advance renewable energy and bioproduct solutions.
Professor Ho Gyu Yoon's research lab specializes in the design and development of advanced functional materials, with a focus on conductive polymer composites, dielectric phantoms for electromagnetic simulation, epoxy resin curing kinetics, and dynamic polymer networks. The lab investigates the structure-property relationships of nanomaterials such as carbon nanotubes, graphene, and metal nanoparticles to enhance electrical, thermal, and electromagnetic shielding performance. A key research direction involves creating stimuli-responsive and self-healing materials through dynamic covalent chemistry, particularly using polysulfide-based networks. The lab also develops predictive kinetic models for polymer curing systems to optimize processing and performance in high-performance applications.
Professor Jin-Woo Bae's research lab focuses on the host-microbiota interactions in human health and disease, with a particular emphasis on the gut microbiome's role in metabolic disorders such as type 2 diabetes and neurodegenerative conditions like Alzheimer’s disease. The lab employs high-throughput sequencing technologies, including 454 pyrosequencing and viral metagenomics, to explore microbial community composition, diversity, and functional dynamics in human fecal and environmental samples. A key research direction involves deciphering how microbial modulation—especially through beneficial taxa like *Akkermansia*—can influence host physiology and offer novel therapeutic strategies. The lab also investigates the impact of medical interventions, such as radiotherapy, on gut microbial homeostasis and associated complications.
Professor Tomoyoshi Nozaki's research lab specializes in molecular parasitology and cell biology, focusing on the evolution and function of organelles in anaerobic eukaryotic parasites, particularly Entamoeba histolytica. The lab investigates mitochondrion-related organelles such as mitosomes and hydrogenosomes, exploring their proteomic composition, metabolic roles, and evolutionary origins in oxygen-limited environments. Key research directions include the biogenesis and maturation of phagosomes, iron-sulfur cluster assembly, and the unique cysteine biosynthesis pathway in these parasites. The lab employs integrative approaches combining proteomics, cell biology, and molecular genetics to decipher fundamental cellular processes in parasitic protists.
Professor Koichiro Yasaka's research lab specializes in medical image analysis and artificial intelligence, focusing on advancing diagnostic accuracy in abdominal and neurological radiology using deep learning and quantitative imaging techniques. The lab investigates the application of convolutional neural networks (CNNs) for liver mass characterization, fibrosis staging, and improved image reconstruction, particularly in CT and MR imaging. Key research directions include radiomics, image noise reduction, and the development of AI tools to support radiologists in clinical decision-making. The lab also explores the impact of imaging protocols and reconstruction methods on texture analysis and diagnostic performance.
Professor Fan-Yan Wei's research lab focuses on the molecular mechanisms of RNA modifications and their roles in gene expression regulation, metabolism, and neurological disorders. The lab investigates tRNA modifications—particularly methylthiotransferase and 2'-O-methyltransferase enzymes—linking these modifications to diseases such as type 2 diabetes, obesity, and X-linked intellectual disability. A central theme is how post-transcriptional RNA modifications fine-tune translation fidelity and efficiency, impacting cellular physiology and disease pathogenesis. The lab integrates biochemical, genetic, and omics approaches to dissect the functional consequences of RNA modifications in vivo and in disease models.
Professor Nobuhisa Yoshikawa's research lab focuses on innovative therapeutic strategies for gynecological malignancies, particularly ovarian and endometrial cancers. The lab investigates plasma-activated medium (PAM) as a novel, non-thermal atmospheric pressure plasma-based therapy with anti-tumor and anti-metastatic effects, emphasizing mechanisms such as autophagy induction and immune modulation. Additionally, the lab explores molecular-targeted agents like PRIMA-1MET for p53-mutant epithelial ovarian cancer and evaluates prognostic biomarkers such as the prognostic nutritional index (PNI) and performance status (PMI) in early- and advanced-stage gynecological cancers. The overarching goal is to translate preclinical findings into clinical applications for improved patient outcomes.
Professor Masato Nagino's research lab specializes in hepatobiliary and pancreatic surgery, with a primary focus on biliary tract cancers—particularly hilar cholangiocarcinoma and bile duct cancer. The lab investigates surgical strategies, including aggressive resection with vascular reconstruction, to improve long-term survival outcomes. It also explores the biological and physiological impacts of biliary obstruction, such as intestinal barrier dysfunction, and evaluates the benefits of bile replacement during biliary drainage. The lab is deeply involved in evidence-based clinical guidelines development to standardize and optimize patient management.
Professor Toshiro Matsui's research lab specializes in the identification and characterization of bioactive natural compounds, particularly polyphenols such as anthocyanins, flavonoids, and phenolic acids, with a focus on their alpha-glucosidase (AGH) inhibitory activities. The lab investigates the postprandial blood glucose-lowering effects of these compounds using in vitro enzyme assays and in vivo animal models, aiming to develop functional foods or nutraceuticals for the prevention and management of type 2 diabetes. A key research direction involves structure-activity relationships of acylated anthocyanins and theaflavins, especially their selective inhibition of maltase over sucrase, which mimics physiological conditions in the small intestine.
Professor Mitsuhiro Terakawa's research lab specializes in laser-based materials processing for sustainable electronics and biomedical applications. The lab focuses on femtosecond and nanosecond laser technologies to enable precise, chemical-free modification of biodegradable polymers and natural biomaterials, such as cellulose nanofibers and poly(lactic acid). Key research directions include laser-induced graphitization for creating conductive carbon structures, laser-mediated gene transfection for targeted therapy, and the development of biodegradable, metal-free triboelectric nanogenerators for eco-friendly electronics. The lab integrates advanced laser processing with materials science to advance green electronics and tissue engineering.
Professor Sejin Kwon's research lab specializes in advanced materials and systems for sustainable energy conversion and storage, with a primary focus on hydrogen generation and fuel cell technologies. The lab develops compact, efficient, and safe hydrogen production systems using chemical hydrides like sodium borohydride and methanol, employing tailored heterogeneous catalysts to enable controlled and continuous hydrogen release. Key research directions include catalytic methanolysis and steam reforming of methanol, as well as the integration of hydrogen generation units with proton exchange membrane fuel cells (PEMFCs) for portable and distributed energy applications. The lab also explores innovative thermal management strategies, such as using hydrogen peroxide decomposition for in-situ heat supply in micro-reformers.
Professor Jong-Gwan Yook's research lab specializes in microwave and millimeter-wave engineering with a focus on non-invasive sensing, advanced antenna design, and electromagnetic compatibility. The lab develops innovative radar-based vital sign monitoring systems, fluidic sensors for biomedical applications, and compact, high-frequency packaging solutions for integrated circuits. Research also extends to anti-drone technologies using intentional electromagnetic interference and bio-inspired pressure sensing systems for wearable and smart sensing applications.
Professor Yong Min Lee's research lab specializes in advanced energy storage systems, with a primary focus on solid-state batteries and lithium-metal batteries. The lab investigates critical interfacial phenomena, such as solid electrolyte interphase (SEI) formation and stabilization, to enhance electrochemical performance and longevity. Key research directions include the development of novel electrolyte additives, innovative electrode architectures with optimized component distribution, and the integration of digital twin technologies for real-time monitoring and prediction of battery behavior. The lab also explores conductive additive synergies and scalable fabrication methods to enable high-energy-density, safe, and durable all-solid-state batteries.
Professor Seul Ki Han's research lab specializes in advanced signal processing, intelligent monitoring systems, and biomedical engineering applications. The lab focuses on developing data-driven methodologies for real-time condition monitoring and predictive maintenance in precision manufacturing, as well as enhancing navigation accuracy through advanced filtering techniques like Kalman filtering. Additionally, the lab explores rehabilitation technologies and human physiological responses to environmental stimuli, particularly in stroke recovery and therapeutic environments. These interdisciplinary efforts integrate sensor fusion, signal analysis, and control systems to improve health outcomes and industrial efficiency.
Professor Myung-Shik Lee's research lab focuses on molecular mechanisms underlying metabolic regulation, insulin resistance, and cellular stress responses, with a particular emphasis on fibroblast growth factor 21 (FGF21), mitochondrial dysfunction, and the interplay between inflammatory cytokines and apoptosis. The lab investigates how metabolic stressors such as free fatty acids and mitochondrial DNA depletion affect cellular signaling pathways, including JNK/IRS-1 and NF-κB, and explores their roles in insulin resistance and metabolic diseases. Additionally, the lab examines the role of growth factors like TGF-β1 in fibrotic processes and the regulation of extracellular matrix remodeling in disease models. Their work integrates molecular biology, cell signaling, and translational metabolism to identify therapeutic targets for diabetes, liver disease, and cancer.
Professor Jiashun Mao's research lab specializes in the integration of machine learning, molecular simulation, and chemical informatics to advance computational drug discovery and materials science. The lab focuses on developing data-driven models that bridge molecular representation (such as IUPAC nomenclature and SMILES) with deep generative models, particularly diffusion models, for intelligent molecular design. A key research direction involves leveraging natural language processing techniques for chemical language to enable interpretable and editable molecular generation, while also improving the accuracy of property prediction—such as dielectric constants—for functional materials. The lab emphasizes the synergy between wet-lab experiments, molecular dynamics simulations, and AI-driven modeling to ensure physical realism and practical applicability.
