探索全球顶尖大学的研究室——研究领域与主要论文一览无余。
Professor Seung Joon Baek's research lab focuses on the molecular mechanisms underlying the chemopreventive and antitumorigenic effects of natural dietary compounds, particularly polyphenols and phytochemicals such as 6-gingerol, resveratrol, and green tea catechins. The lab investigates how these compounds modulate key signaling pathways—especially those involving NAG-1, Egr-1, and PPARγ—leading to apoptosis and cell cycle arrest in colorectal and other cancers. A central theme is the identification of PPARγ-independent mechanisms of action for anti-cancer agents, with a strong emphasis on transcription factor regulation and stress-response pathways. The lab also explores novel imaging tools, such as the lux system, for real-time visualization of biological processes in living cells.
Professor Young-Jun Lim's research lab specializes in biomaterials and oral implantology, focusing on the development and evaluation of titanium-based implant surfaces to enhance osseointegration and tissue response. The lab investigates the biomechanical and biological interactions between dental implants and host tissues, with particular emphasis on surface properties such as roughness and wettability. Additionally, the lab explores advanced drug delivery systems using electrospun fibers for chronic wound healing applications, especially in diabetic conditions. Their work integrates clinical imaging, computational modeling, and translational research to improve the accuracy and predictability of guided implant surgery.
Professor Sang-Kyu Ye's research lab focuses on the molecular mechanisms underlying cancer progression, neurodegenerative disorders, and inflammatory diseases, with a central emphasis on the role of STAT3 signaling in disease pathogenesis. The lab investigates how dysregulated signaling pathways—particularly IL-6/STAT3, NF-κB, and HIF-1α—contribute to tumor microenvironment formation, cancer stemness, and tissue damage in conditions such as liver cancer, colitis, and diabetic encephalopathy. A key research direction involves developing and evaluating small molecule inhibitors, such as ODZ10117, to target STAT3 for cancer therapy. The lab also explores the biological effects of physical forces, including simulated microgravity, on cancer cell behavior, revealing novel anticancer mechanisms.
Professor Soon-Tae Lee's research lab focuses on innovative neurotherapeutic strategies for neurological emergencies and neurodegenerative diseases, with a strong emphasis on translational neuroscience. The lab investigates neuroprotective mechanisms in stroke and epilepsy, exploring cell-based therapies such as neural stem cell transplantation, miRNA regulation of neurotrophic factors like BDNF, and novel drug delivery systems. A key focus is on developing personalized, implantable medical devices for real-time treatment of conditions like status epilepticus, integrating wireless monitoring with on-demand drug release. The lab also explores natural compounds, such as Panax ginseng, for cognitive enhancement in Alzheimer’s disease, combining preclinical and clinical approaches.
Professor Tae Hui Kim's research lab specializes in digital mental health interventions and neuropsychological assessment, with a focus on developing and evaluating brief, reliable, and culturally adapted tools for screening cognitive and mental health conditions in older adults. The lab investigates the efficacy of internet-based psychological therapies—such as iACT and iBA—across diverse populations, particularly in addressing depression, anxiety, and quality of life. A key research direction involves validating clinical instruments like the SMMSE-DS and FAB-K for use in diverse geriatric populations with varying educational backgrounds.
Professor Seong Wook Yang's research lab specializes in the development of novel nanomaterial-based biosensors, with a strong focus on DNA-silver nanoclusters (DNA/AgNCs) for sensitive and selective detection of microRNAs—key biomarkers in disease diagnosis and developmental regulation. The lab explores the fundamental principles of DNA-nanomaterial interactions, particularly how DNA secondary structures influence the formation and optical properties of AgNCs, enabling applications in multiplexed diagnostics and live-cell imaging. Additionally, the lab investigates molecular mechanisms in plant stress responses, especially the roles of phytochromes and ubiquitin-proteasome systems in regulating developmental plasticity under environmental stress. These interdisciplinary efforts bridge nanotechnology, molecular biology, and plant systems biology to create innovative tools for biomedical and agricultural biotechnology.
Professor Gilsoo Jang's research lab specializes in power system stability, control, and power quality enhancement, with a strong focus on nonlinear dynamics, harmonic mitigation, and HVDC integration. The lab develops advanced control strategies using nonlinear analysis techniques such as the method of normal forms to improve system resilience under stressed conditions. It also addresses challenges in high-penetration renewable integration and transmission system stability, particularly in small and isolated power systems. The lab's work emphasizes practical solutions through optimal reactive power compensation, fault analysis, and secure power flow control using PTDF and LODF formulations.
Professor James Jungho Pak's research lab specializes in advanced functional materials and their applications in energy conversion, micro-electromechanical systems (MEMS), and electronic devices. The lab focuses on developing novel nanomaterials such as ionic polymer-metal composites (IPMCs), cellulose-based fibers, and transition metal oxide/fluoride heterostructures for use in micro-actuators, micro-pumps, supercapacitors, and electrocatalysts for hydrogen evolution. Key research directions include resistive switching memory (RRAM) devices with multilayer insulating structures, scalable synthesis of ultrathin 2D materials like BiOCl, and electrowetting-based droplet manipulation for lab-on-a-chip systems. The lab emphasizes materials design, device fabrication, and comprehensive electrochemical and physical characterization to enable high-performance, stable, and scalable technologies.
Professor Han Ah Lee's research lab specializes in hepatology and metabolic liver disease, with a strong focus on the intersection of metabolic dysfunction–associated steatotic liver disease (MASLD), cardiovascular risk, and hepatocellular carcinoma (HCC). The lab investigates the pathophysiology, prognostic markers, and treatment outcomes in chronic liver diseases, particularly the transition from immune-tolerant to active hepatitis B, the role of immune cells like NK cells in HCC progression, and the impact of vascular invasion on HCC prognosis. The team also explores longitudinal risk factors and personalized management strategies for MASLD-related cardiovascular disease.
Professor Jaehyuck Jang's research lab specializes in nanophotonics and metamaterials, focusing on the design and application of advanced optical structures for sensing, imaging, and secure information technologies. The lab develops tunable structural color devices, including ultrafast humidity sensors and dynamic color printing, using materials such as chitosan hydrogels and dielectric metasurfaces. Key research directions include hybridized Mie-lattice resonances, Kerker's condition-based metasurfaces, and polarization-encrypted nanoprints for next-generation security and IoT applications. The lab bridges fundamental photonics with practical devices, emphasizing low-loss, high-sensitivity, and energy-efficient optical systems.
Professor Seog Ju Kim's research lab focuses on the neurobiological and psychological underpinnings of trauma-related disorders, particularly posttraumatic stress disorder (PTSD), ADHD, and sleep-wake disturbances in adolescents and young adults. The lab employs advanced neuroimaging techniques such as diffusion tensor imaging (DTI) to investigate white matter integrity and neurochemical markers like GABA in brain regions associated with emotion regulation and attention. A key research direction involves understanding how circadian phenotypes—such as morningness-eveningness preferences—and sleep patterns, including weekend catch-up sleep, contribute to cognitive and psychiatric outcomes. The lab also evaluates the efficacy of trauma-focused psychotherapies, such as narrative exposure therapy, in refugee populations and clinical populations with sleep and mood disorders.
Professor Geum-Youn Gwak's research lab focuses on the pathophysiological links between non-alcoholic fatty liver disease (NAFLD) and systemic metabolic and cardiovascular diseases. The lab investigates how NAFLD, even in the absence of obesity or traditional risk factors, contributes to the development of atherosclerosis, insulin resistance, diabetes, and colorectal neoplasia. A key research direction involves identifying high-risk subgroups—particularly those with 'lean NAFLD'—to enable early intervention and improve clinical outcomes. The lab also explores prognostic factors in hepatocellular carcinoma, especially in advanced-stage disease, to refine patient stratification and treatment strategies.
Professor Seon-Cheol Park's research lab focuses on the neurobiological and clinical aspects of mood and psychotic disorders, with a particular emphasis on the interplay between stress, inflammation, and depression. The lab investigates clinical phenotypes of major depressive disorder (MDD), including the role of age at onset and insomnia as key indicators of disease severity and prognosis. It also conducts systematic reviews and meta-analyses to evaluate treatment efficacy and safety, especially comparing long-acting injectable and oral second-generation antipsychotics in schizophrenia. The lab aims to improve diagnostic accuracy and treatment strategies through evidence-based psychiatry and translational research.
Professor Seung-Jun Shin's research lab specializes in smart manufacturing and industrial data analytics, focusing on the integration of big data, machine learning, and advanced sensing to enhance manufacturing efficiency, sustainability, and predictive capability. The lab develops intelligent systems for real-time monitoring, modeling, and optimization of manufacturing processes—particularly in metal cutting—by leveraging data-driven approaches and interoperable platforms like OPC UA. A key focus is enabling self-learning factories through holonic systems and hybrid learning models that allow machines to autonomously anticipate performance outcomes based on historical data and real-time conditions. The lab also explores cutting-edge nanoscale devices, such as ultra-small single-electron transistors, for next-generation smart manufacturing components.
Professor Kenji Kondo's research lab focuses on the intersection of aging, sensory function, and natural products, with a particular emphasis on olfactory neurobiology and the molecular identification of medicinal plants. The lab investigates age-related changes in olfactory neuroepithelium, including neurogenesis and cell death, using animal models to understand the mechanisms underlying smell dysfunction in aging. Additionally, the lab employs molecular DNA markers to accurately identify and characterize medicinal licorice species, linking genetic profiles to their bioactive constituents. Recent work also explores the potential of phytochemicals in supporting recovery from post-viral olfactory disorders, such as those seen in COVID-19.
Professor Kaori Fukuzawa's research lab specializes in the theoretical and computational investigation of molecular interactions in biological and astrochemical systems. The lab focuses on applying advanced quantum mechanical methods—particularly the fragment molecular orbital (FMO) approach—to study biomolecular recognition, protein-ligand interactions, and the electronic origins of binding affinities in estrogen receptors and other macromolecular complexes. Additionally, the lab explores the mechanisms of neutral-neutral reactions in interstellar environments, aiming to understand the formation pathways of complex organic molecules such as cyanopolyynes and cyanoacetylenes. Their work bridges computational chemistry, structural biology, and astrochemistry through high-accuracy ab initio calculations and the development of public databases for data sharing and analysis.
Professor Yutaka Akiyama's research lab specializes in computational biology and bioinformatics, focusing on the development of advanced algorithms and simulation methods for drug discovery and systems biology. Key research directions include protein-protein interaction prediction, cyclic peptide drug design with an emphasis on membrane permeability, and high-throughput homology search for metagenomic data. The lab integrates computational techniques such as molecular dynamics simulations, machine learning, and structural bioinformatics to address challenges in drug target identification and virtual screening.
Professor Albert Escrivà's research lab specializes in theoretical and numerical cosmology, focusing on the formation mechanisms and astrophysical implications of primordial black holes (PBHs) in the early Universe. The lab investigates the critical conditions for PBH formation from primordial curvature fluctuations, particularly through detailed numerical simulations of spherically symmetric perturbations in radiation- and matter-dominated cosmological backgrounds. A central theme is the development of accurate threshold criteria for black hole formation, including the role of non-Gaussianities, equation of state variations (e.g., during the QCD crossover), and the shape of curvature profiles. The lab also explores the resulting PBH mass functions and their observational signatures, such as merger rates and constraints from cosmic microwave background and gravitational wave data.
Professor Shoji Kawakatsu's research lab specializes in advanced surgical oncology, with a primary focus on minimally invasive techniques for gastrointestinal malignancies, particularly gastric and colorectal cancers. The lab investigates optimal surgical strategies, including laparoscopic gastrectomy and simultaneous resection of synchronous metastases, to improve patient outcomes and postoperative recovery. Key research directions include surgical margin assessment, management of rare metastatic patterns—such as intrapancreatic bile duct metastasis—and the impact of postoperative complications on long-term survival in high-risk patients like those with perihilar cholangiocarcinoma. The lab emphasizes evidence-based surgical decision-making, integrating diagnostic precision with patient-centered outcomes.
Professor Soji Shimizu's research lab specializes in the synthesis and characterization of expanded and contracted porphyrinoids, with a focus on novel macrocyclic architectures such as subporphyrins, expanded porphyrins, and aza-BODIPY analogues. The lab explores their unique electronic structures, nonlinear optical properties, and metal coordination behaviors, particularly in systems with large cavities and tunable optical properties. Recent work emphasizes molecular design for near-infrared absorption and emission, leveraging DFT calculations and advanced spectroscopic techniques to develop functional chromophores for optoelectronic and sensing applications.
