探索全球顶尖大学的研究室——研究领域与主要论文一览无余。
Professor Junya Yamagishi's research lab specializes in molecular parasitology and infectious disease genomics, focusing on understanding host–parasite interactions at the transcriptomic and genomic levels. The lab develops and applies next-generation sequencing technologies, including RNA-seq and nanopore sequencing, to study tropical pathogens such as *Plasmodium falciparum*, dengue virus, and *Trypanosoma* species in clinical and environmental settings. A key research direction involves creating rapid, field-deployable molecular diagnostics for infectious diseases in resource-limited settings, integrating sample preparation, amplification, and sequencing into streamlined workflows. The lab also contributes to epidemiological surveillance by characterizing pathogen diversity and evolution through high-throughput sequencing of clinical and vector samples.
Professor Zhen Yan's research lab specializes in sustainable construction technologies, with a focus on biocementation for soil improvement and extraterrestrial habitat development. The lab explores enzyme-induced calcium carbonate and phosphate precipitation (EICP/EICPP) using low-cost, locally sourced materials such as eggshells, bones, and urine to enhance biocement properties while minimizing environmental impact. A key research direction involves optimizing biocementation processes under extreme conditions, including microgravity, to support long-term space exploration and in-situ resource utilization (ISRU). The lab also investigates ancient cement technologies to inspire modern, durable, and eco-friendly construction materials.
Professor Yoshiyuki Kageyama's research lab specializes in the design and fabrication of biomimetic molecular systems that exhibit autonomous, self-organized mechanical motions. The lab focuses on creating light-driven supramolecular assemblies—particularly those based on oleic acid and azobenzene derivatives—that display continuous, limit-cycle oscillations and forceful motions such as flipping and coiling under irradiation. By leveraging noncovalent interactions and photoresponsive molecular switching, the lab aims to develop autonomous microrobots with intrinsic self-control mechanisms, mimicking the dynamic behaviors seen in biological systems. Their work bridges molecular chemistry, materials science, and nanomechanics to realize next-generation intelligent soft materials.
Professor Taihiko Yamaguchi's research lab specializes in the development and application of portable, wearable electromyographic (EMG) devices for the objective assessment of oromotor activities, particularly sleep and awake bruxism. The lab focuses on advancing diagnostic tools that enable long-term, ambulatory monitoring of masseter muscle activity in real-life settings, emphasizing reliability, miniaturization, and practical usability. Key research directions include establishing valid cut-off values for EMG-based bruxism detection, optimizing measurement duration for accurate diurnal bruxism assessment, and characterizing the biomechanical signatures of rhythmic masseteric activity. The lab's work bridges clinical dentistry, biomedical engineering, and wearable health technology to improve the diagnosis and management of orofacial movement disorders.
Professor Koshi Nakamura's research lab focuses on the intersection of cardiovascular health, lifestyle factors, and metabolic biomarkers, with a strong emphasis on population-based epidemiology in Japanese cohorts. Key research directions include the impact of smoking, hypertension, and chronic kidney disease on cardiovascular outcomes, as well as the role of gut microbiota-derived short-chain fatty acids (SCFAs) in metabolic and cardiovascular health. The lab also investigates environmental and dietary risk factors—such as alcohol consumption—contributing to hypertension and related diseases in the Japanese population. Additionally, the lab explores advanced materials science, particularly the development of novel magnetic targets for high-rate sputtering in thin-film deposition.
Professor Koichi S. Kobayashi's research lab focuses on innate immune sensing mechanisms in intestinal homeostasis and inflammation, with a central emphasis on Nod-like receptors (NLRs), particularly Nod2, and their roles in regulating host-microbe interactions. The lab investigates how Nod2 detects bacterial components and orchestrates antimicrobial responses, including the induction of cryptdins and control of commensal and pathogenic bacteria in the gut. Additionally, the lab explores the regulation of apoptosis and cell survival through IAP proteins, such as TIAP, and their implications in immune cell function and tissue integrity. The research integrates molecular immunology, microbiology, and in vivo models to uncover mechanisms underlying inflammatory bowel diseases like Crohn’s disease and to identify therapeutic targets for immune-mediated disorders.
Professor Atsuhiro Kanda's research lab focuses on molecular and genetic mechanisms underlying retinal diseases, particularly age-related macular degeneration (AMD) and inherited retinal dystrophies. The lab investigates genetic risk variants, such as those in the 10q26 locus involving HTRA1 and ARMS2, and their functional impact on disease susceptibility. It also explores the role of angiogenic factors like VEGF and novel therapeutic targets, including aflibercept's interaction with galectin-1, in ocular neovascularization disorders. Additionally, the lab examines transcriptional regulation in photoreceptor development through studies on the NRL transcription factor and its disease-associated mutations.
Professor Takafumi Inoue's research lab focuses on cellular and molecular mechanisms underlying neuronal signaling and gene regulation in the nervous system. Key research directions include the role of intracellular calcium signaling, particularly through the inositol 1,4,5-trisphosphate receptor type 1 (IP3R1), in synaptic plasticity and neuronal function. The lab also investigates transcriptional regulation in the brain, especially the function of nuclear factor I (NFI) family proteins in cell-type-specific gene expression, such as in myelin basic protein regulation. Additionally, the lab employs advanced imaging techniques to study membrane protein dynamics, including lateral diffusion of IP3R1 in neurons. These studies integrate molecular biology, cell biology, and live-cell imaging to uncover fundamental mechanisms in neuroscience and gene regulation.
Professor Norihisa Miki's research lab specializes in microsystems and biomedical engineering, focusing on the development of miniaturized, implantable, and wearable devices for healthcare applications. Key research directions include microfluidic systems for implantable dialysis, tactile feedback technologies using piezoelectric and hydraulic actuation, and wearable sensors for real-time physiological monitoring such as mental fatigue detection. The lab emphasizes low-power, compact, and biocompatible solutions, integrating materials like PDMS, PES membranes, and flexible electronics for next-generation medical devices.
Professor Yoshiaki Furukawa's research lab focuses on the molecular mechanisms underlying neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and related proteinopathies. The lab investigates the roles of misfolded and aggregated proteins—such as mutant superoxide dismutase 1 (SOD1) and TDP-43—in neuronal toxicity, with a strong emphasis on the structural and biochemical transitions during protein maturation, including metal binding, disulfide bond formation, and oxidative stress responses. Using biochemical, cell biological, and structural approaches, the lab explores how immature or misfolded forms of these proteins drive disease pathogenesis, aiming to identify early pathological events and potential therapeutic targets. The work also extends to understanding the role of chaperone proteins like CCS in SOD1 activation and quality control.
Professor Kentaro Yoshioka's research lab specializes in advanced analog and mixed-signal integrated circuit design, with a strong focus on high-performance, low-power data converters and sensor systems for emerging applications in healthcare and autonomous systems. The lab develops innovative architectures such as TDC/ADC hybrid LiDAR SoCs and energy-efficient ADCs for wireless communications, emphasizing high resolution, wide dynamic range, and ultra-low power consumption. Their work also spans biomedical engineering, particularly in predicting therapeutic outcomes for hepatitis C using molecular diagnostics and genotypic analysis. The lab bridges cutting-edge semiconductor technology with real-world health and safety challenges.
Professor Éric Collet's research lab specializes in the dynamic structural and electronic behavior of functional molecular materials, with a focus on spin-crossover systems, charge-transfer materials, and metal-organic frameworks. The lab investigates ultrafast photoinduced phase transitions, structural ordering, and the coupling between electronic, magnetic, and lattice degrees of freedom using advanced time-resolved X-ray diffraction and spectroscopic techniques. Key research directions include femtosecond structural dynamics, long-range order formation in spin-state concentration waves, and the interplay between molecular-scale changes and macroscopic material properties.
Professor Kimihiro Hashiba's research lab specializes in rock mechanics, with a focus on the time-dependent behavior, strength characteristics, and failure mechanisms of rocks under various loading conditions. The lab investigates fundamental mechanical responses such as creep, strain-rate dependency, and post-failure behavior, particularly in tension and triaxial compression. Their work integrates experimental testing, long-term monitoring, and advanced constitutive modeling—such as the variable-compliance (VC) model—to simulate complex rock deformation and fracture processes.
Professor Meng Ling Moi's research lab focuses on the immunology and virology of dengue virus, with a particular emphasis on antibody-dependent enhancement (ADE), host immune responses, and viral pathogenesis. The lab investigates how sub-neutralizing antibodies and cross-reactive immunity—especially from Japanese encephalitis virus vaccination—can exacerbate dengue infection through Fc gamma receptor-mediated mechanisms. Using in vitro models, patient samples, and molecular virology techniques, the lab explores viral load dynamics, diagnostic markers like NS1 antigen, and the role of host factors in disease severity. Their work contributes significantly to understanding dengue immunopathology and improving diagnostics and vaccine development.
Professor Shinya Sugiura's research lab specializes in advanced multiple-antenna wireless communication systems, with a strong focus on innovative modulation and signal processing techniques for next-generation wireless networks. The lab pioneers novel frameworks such as Space-Time Shift Keying (STSK), Generalized Space-Time Shift Keying (G-STSK), and faster-than-Nyquist (FTN) signaling, emphasizing spectral efficiency, low-complexity detection, and flexible diversity-multiplexing tradeoffs. Their work bridges theoretical innovation with practical implementation, particularly in MIMO systems, index modulation, and frequency-domain equalization for high-data-rate transmission. The lab also contributes to the design of low-complexity, iterative detection schemes that approach capacity in frequency-selective fading channels.
Professor Kazuyuki Motohashi's research lab specializes in innovation economics and industrial dynamics, with a focus on university-industry collaboration, small and medium-sized enterprise (SME) innovation, and the role of institutional frameworks in fostering technological advancement. The lab conducts empirical and quantitative analyses of innovation systems, particularly in Japan and China, examining R&D collaboration, patenting behavior, open innovation, and the impact of science and technology policies on firm performance. A central theme is understanding how firms—especially SMEs—leverage external knowledge and institutional support to enhance innovation productivity in increasingly complex and competitive environments.
Professor Hiroshi Imamizu's research lab specializes in cognitive and computational neuroscience, focusing on the neural mechanisms underlying motor control, learning, and internal modeling in the human brain. The lab investigates how the cerebellum supports dexterous tool use through modular neural organization and internal models, particularly in the context of sensorimotor adaptation and cognitive functions. Using advanced neuroimaging techniques such as fMRI and connectivity-based neurofeedback, the lab explores functional brain network reorganization during skill learning and intermanual transfer. A central theme is understanding the balance between structured and tabular representations in motor learning and generalization.
Professor Yasuo Ohnishi's research lab specializes in microbial natural product biosynthesis, with a focus on Streptomyces species as model organisms. The lab investigates the genetic and molecular mechanisms underlying the production of bioactive compounds such as antibiotics (e.g., streptomycin), terpenoids (e.g., (+)-caryolan-1-ol), and benzastatins, emphasizing regulatory pathways, enzyme function, and gene cluster characterization. Key research directions include the identification and functional analysis of regulatory systems (e.g., A-factor/AdpA signaling), terpene cyclases, and cytochrome P450 enzymes involved in complex natural product formation.
Professor Ying-Wen Chen's research lab specializes in atmospheric modeling and climate science, with a focus on high-resolution global nonhydrostatic models to study cloud microphysics, radiative feedbacks, and precipitation processes under global warming. The lab investigates the role of ice hydrometeors—such as snow, graupel, and cloud ice—in Earth's radiation balance and climate sensitivity, using advanced models like NICAM and data assimilation techniques to integrate satellite observations (e.g., GPM) for improved weather and climate prediction. Their work bridges numerical modeling, remote sensing, and data assimilation, particularly through ensemble-based methods like LETKF, to enhance the accuracy of atmospheric simulations and climate projections.
Professor André Röhm's research lab specializes in nonlinear dynamics, reservoir computing, and photonic systems, with a focus on leveraging the computational potential of complex dynamical systems—particularly in delay-coupled and time-multiplexed optical networks. The lab investigates chaotic systems, synchronization phenomena such as chimera states, and the application of reservoir computing in photonic and semiconductor laser systems for machine learning and signal processing. A key direction involves the theoretical and numerical analysis of laser-based neuromorphic computing platforms, including quantum-dot lasers and delay-coupled systems, to enable hardware-efficient, high-speed information processing.
