[论文解读] Prevalence and Associated Factors of Human Papillomavirus Infection among Iraqi Women

Maitham G. Yousif, Fadhil G. Al-Amran+2 more|arXiv (Cornell University)|Jul 27, 2023

Cervical Cancer and HPV Research被引用 14

一句话总结

本研究估计在伊拉克卫生中心就诊的15-50岁伊拉克女性中的HPV患病率，并描述与之相关的因素，包括宫颈细胞学结果。研究发现HPV阳性率为17.96%，阳性者中CIN的分布显著。

ABSTRACT

Human papillomavirus (HPV) is a significant public health concern, as it is a leading cause of cervical cancer in women. However, data on the prevalence of HPV infection among Iraqi women is scarce. This study aimed to estimate the prevalence of HPV infection and its associated factors among Iraqi women aged 15-50 attending health centers. In this cross-sectional study, 362 female participants aged 15-50 were recruited from health centers in Iraq. Serological tests were used to screen for HPV infection. Sociodemographic information, obstetric history, and contraceptive use were collected. Pap smears were performed to assess cervical changes related to HPV infection. Of the 362 participants, 65 (17.96%) tested positive for HPV. The majority of HPV-positive women were aged 30-35 years, housewives, and belonged to lower social classes. Among HPV-positive women, 30% had abnormal Pap smears, with 55% diagnosed with cervical intraepithelial neoplasia grade 1 (CIN1), 25% with CIN2, and 15% with CIN3. Biopsy confirmed the diagnosis in 5% of cases. No significant association was found between HPV infection and contraceptive use. Most HPV-positive women were multiparous. This study reveals a considerable prevalence of HPV infection among Iraqi women attending health centers, particularly in the age group of 30-35 years and among housewives. These findings highlight the need for targeted public health interventions to increase HPV awareness, promote regular screening, and improve access to healthcare services for women, especially those from lower social classes. Further research is warranted to better understand the factors contributing to HPV transmission in Iraq and to develop effective prevention strategies.

研究动机与目标

• 估计在伊拉克卫生中心就诊的15-50岁伊拉克女性的HPV感染患病率。
• 确定与HPV感染相关的社会人口学、产科和避孕因素。
• 评估与HPV感染相关的宫颈细胞学变化（巴氏涂片）及活检确诊的诊断。

提出的方法

• 横断面研究设计，招募来自伊拉克卫生中心的362名年龄在15-50岁的女性参与者。
• HPV感染通过血清学检测进行筛查。
• 收集社会人口学因素、产科史及避孕使用情况。
• 进行巴氏涂片以评估HPV相关的宫颈变化。
• 在选定病例中进行活检以确诊宫颈病变。

实验结果

研究问题

• RQ1 在就诊于卫生中心的15-50岁伊拉克女性中，HPV感染的患病率是多少？
• RQ2 在该人群中，哪些社会人口学、产科和避孕因素与HPV感染相关？
• RQ3 在HPV阳性女性中观察到哪些宫颈细胞学异常，以及活检证实CIN病变的频率如何？

主要发现

• 362名参与者中有65人 HPV 阳性（17.96%）。
• 在HPV阳性女性中，绝大多数年龄为30-35岁、为家庭主妇、来自较低社会阶层。
• 在HPV阳性女性中，30%有异常的巴氏涂片；CIN1占55%，CIN2占25%，CIN3占15%。
• 在HPV阳性病例中，活检证实占5%。
• 未发现HPV感染与避孕使用之间存在显著关联。
• 大多数HPV阳性女性为经产妇。