东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Jun Inamoto's research lab focuses on unraveling the immunological and molecular mechanisms underlying autoimmune diseases, particularly rheumatoid arthritis (RA) and systemic sclerosis (SSc), using cutting-edge single-cell and long-read sequencing technologies. The lab investigates T cell dysfunction, alternative splicing, and immune cell phenotypes in at-risk and early-stage patients to identify novel biomarkers and therapeutic targets. A key emphasis is on understanding disease pathogenesis before clinical onset, aiming to enable early intervention and remission strategies.
Professor Masatoshi Sakurai's research lab focuses on the molecular mechanisms underlying hematopoietic stem cell regulation and inherited blood disorders, particularly familial platelet disorder/acute myeloid leukemia (FPD/AML). The lab investigates the pathogenic roles of RUNX1 mutations and chromosomal abnormalities in hematopoietic stem cell dysfunction and leukemogenesis. Using genetic and molecular approaches, the lab explores the functional consequences of RUNX1 mutations and the potential of umbilical cord blood as a therapeutic resource in hematopoietic stem cell transplantation. Their work bridges basic genetics with clinical applications in hematology and regenerative medicine.
Professor Tomoyoshi Soga's research lab specializes in metabolomics, focusing on the comprehensive and quantitative analysis of charged, hydrophilic metabolites using advanced capillary electrophoresis-mass spectrometry (CE-MS) techniques. The lab develops innovative analytical methods—particularly CE-ESI-MS and CE-TOFMS—in negative and positive ion modes to enable high-resolution separation and sensitive detection of metabolites, including amino acids, nucleotides, and intermediates of central carbon metabolism. Their work emphasizes method optimization for metabolite extraction, ionization efficiency, and instrument stability, especially in handling anionic metabolites prone to metal ion interference. The lab applies these methods to study dynamic metabolic responses in model microorganisms such as *Bacillus subtilis* and *Escherichia coli* under genetic and environmental perturbations.
Professor Shigeki Yamada's research lab specializes in cerebrovascular and neurodegenerative disorders, with a focus on intracranial aneurysms, arteriovenous malformations (AVMs), and the pathophysiology of normal pressure hydrocephalus (iNPH). The lab investigates genetic factors in familial clustering of cerebrovascular diseases and identifies novel imaging biomarkers—such as z-Evans index and ventricular expansion parameters—for differentiating iNPH from Alzheimer’s disease. They also explore vascular risk factors, including transfusion history and small vessel disease, in relation to cerebral microbleeds and hemorrhagic stroke outcomes. Their work bridges clinical neurology, medical imaging, and genetics to improve early diagnosis and risk stratification in cerebrovascular diseases.
Professor Masayuki Miura's research lab focuses on the molecular mechanisms of programmed cell death, particularly apoptosis, and its roles in development, disease, and tissue homeostasis. The lab investigates caspase family proteins, such as ICE/CED-3 and DRONC, in mediating apoptosis and its downstream effects, including compensatory proliferation in Drosophila. They also study the role of signaling molecules like TNF and IL-1β in cell death pathways, especially in glial cells and neurons. Additionally, the lab explores cell adhesion molecules, such as L1, and their functions in neural development, migration, and cell-cell interactions.
Professor Satoshi Watanabe's research lab specializes in advanced materials and surface science, focusing on the electronic and structural properties of low-dimensional systems, including atomic-scale wires and functional surfaces. The lab investigates phenomena such as two-color laser control in ionization dynamics, conductive polymer electrodes for flexible actuators, and the atomic-scale electronic structures of semiconductor surfaces. Their work bridges theoretical first-principles calculations with experimental characterization, particularly in scanning tunneling microscopy and electroactive materials. The lab also explores smart materials with tunable responses to electric fields, such as bending polyurethane films with tailored chemical structures.
Professor Tatsuhiko N. Ikeda's research lab specializes in theoretical and applied quantum physics, with a focus on nonequilibrium quantum systems, thermalization mechanisms in isolated quantum systems, and the development of advanced spectroscopic techniques for real-time quality assessment in agriculture and food science. The lab investigates foundational quantum phenomena such as eigenstate thermalization and nonequilibrium steady states in driven-dissipative systems, while also applying cutting-edge analytical and spectroscopic methods—like FT-NIR and metabolomics—to practical challenges in green tea quality evaluation. The integration of quantum many-body theory with experimental data-driven approaches defines the lab’s interdisciplinary approach.
Professor Shinji Nakaya's research lab specializes in geophysical and geochemical processes related to earthquake dynamics, groundwater systems, and fracture network modeling. The lab investigates seismicity patterns using statistical seismology, including temporal variations in b values and multifractal dimensions of seismicity, to understand the precursory signals of large earthquakes. It also explores stable isotope tracers in hydrogeological systems and applies 3D fractal fracture network models to analyze fluid flow and percolation in hard rocks. The integration of field data, numerical modeling, and advanced laser diagnostics (e.g., NO-LIF) enables a multidisciplinary approach to natural hazard assessment and subsurface fluid dynamics.
Professor Kenji Satake's research lab specializes in tsunami hazard assessment, focusing on the numerical modeling of tsunami generation, propagation, and runup. The lab investigates the coseismic slip distributions of large earthquakes using tsunami waveform data, with particular emphasis on understanding 'tsunami earthquakes'—events that generate disproportionately large tsunamis despite moderate seismic magnitudes. Their work integrates detailed bathymetry, fault modeling, and inverse methods to improve tsunami source estimation and long-term hazard forecasting.
Professor Alessandro A. Trani's research lab specializes in theoretical and computational astrophysics, focusing on the dynamical evolution of stellar-mass black holes in dense astrophysical environments such as young massive star clusters and galactic nuclei. The lab investigates the formation, spin properties, and merger dynamics of black hole binaries through advanced N-body simulations, binary population synthesis, and three-body dynamics, with particular attention to the influence of tidal fields, common envelope evolution, and dynamical interactions. Their work contributes to understanding gravitational-wave source populations and the role of extreme environments in shaping compact object evolution. The lab also explores chaotic dynamics and Lévy flights in the three-body problem, developing novel metrics to characterize complex gravitational interactions.
Professor Rwitajit Majumdar's research lab specializes in learning analytics, educational technology, and digital pedagogy, with a focus on enhancing self-directed learning, critical reading, and the design of interactive digital tools for education. The lab develops data-driven visual analytics platforms—such as iSAT and BookRoll—to support formative assessment, learner engagement, and the systematic analysis of student behaviors in both online and blended learning environments. A key research direction involves the digitization of traditional knowledge systems, exemplified by the development of a mobile-based framework for teaching Bharatanatyam, an Indian classical dance form, through gamified, grammar-based digital interaction. The lab also investigates the impact of emergency remote teaching during crises like the COVID-19 pandemic, emphasizing the role of e-book platforms and AI in sustaining educational continuity.
Professor Kazuho Okada's research lab specializes in the microstructural and crystallographic mechanisms of hydrogen embrittlement in high-strength steels, with a focus on martensitic and ferritic-pearlitic microstructures. The lab investigates how carbon segregation at prior austenite grain boundaries enhances resistance to hydrogen-induced intergranular fracture, while also examining the role of dislocation dynamics, slip systems, and fracture surface topography in quasi-cleavage and transgranular fracture modes. Key research directions include the influence of hydrogen on dislocation morphology, crack initiation at block boundaries, and the crystallographic control of fracture path in low-carbon steels. The lab employs advanced characterization techniques such as EBSD, TEM, neutron diffraction, and SEM-BSE to elucidate atomic-scale and microscale deformation and fracture processes under hydrogen exposure.
Professor Jun Tanida's research lab specializes in computational optics, optical computing, and advanced imaging systems. The lab focuses on developing innovative optical-digital hybrid systems that leverage principles such as compound-eye imaging, lensless optics, and phase retrieval to enable compact, high-performance imaging and computing. Key research directions include computer-generated holography using deep learning, optical parallel logic systems for real-time processing, and non-invasive 3D imaging through turbid media using speckle correlation techniques. The lab bridges fundamental optics with practical applications in medical imaging, robotics, and next-generation optical sensors.
Professor Tomohiko Hojo's research lab specializes in the development and characterization of ultra-high-strength low-alloy steels, with a primary focus on hydrogen embrittlement resistance and delayed fracture behavior in advanced TRIP-aided steels. The lab investigates the effects of alloying elements—particularly aluminum, chromium, and vanadium—on hydrogen trapping mechanisms, phase transformation behavior, and mechanical properties in steels with bainitic ferrite and martensite matrices. Key research directions include optimizing microstructure design to enhance hydrogen tolerance and improving the reliability of high-strength steels for automotive applications through advanced testing techniques such as thermal desorption spectroscopy and four-point bending tests.
Professor Naoki Suzuki's research lab focuses on the molecular mechanisms underlying neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and related motor neuron disorders. The lab investigates key pathways involved in axonal degeneration, protein homeostasis, and muscle atrophy, with a strong emphasis on transcription factors like Foxo, the role of dystrophin-associated proteins such as nNOS, and the pathogenic significance of FUS/TLS protein aggregates. Additionally, the lab explores therapeutic strategies, including antisense oligonucleotide (ASO) therapy, for genetic forms of ALS and examines the contribution of immune cells and metabolic stress in disease progression.
Professor Di Zhang's research lab specializes in the design, synthesis, and fundamental understanding of advanced electrocatalysts, particularly metal-nitrogen-carbon single-atom catalysts (M-N-C SACs), for sustainable energy conversion and storage applications. The lab focuses on unraveling the structure-activity relationships in these catalysts, especially their pH-dependent oxygen reduction reaction (ORR) mechanisms, electron transfer pathways, and the identification of rate-determining steps. By integrating high-throughput computational screening with experimental validation, the lab aims to develop efficient, low-cost alternatives to platinum-group catalysts for fuel cells and metal-air batteries. Their work bridges atomic-scale electronic structure insights with practical electrocatalytic performance, advancing the field of electrocatalysis for clean energy technologies.
Professor Francesco Buscemi's research lab specializes in foundational aspects of quantum information theory, with a focus on quantum measurement, quantum channels, and the operational principles underlying quantum correlations. The lab investigates the interplay between quantum resources—such as entanglement, coherence, and nonlocality—and information-theoretic frameworks, particularly through the lens of nonlocal games, one-shot information theory, and quantum data processing. Key themes include the characterization of quantum operations, the role of shared randomness and classical communication, and the development of information-theoretic measures for noise, disturbance, and irreversibility in quantum processes.
Professor Yusuke Murakami's research lab focuses on understanding the molecular mechanisms underlying photoreceptor cell death in retinal degenerative diseases, particularly retinitis pigmentosa (RP). The lab investigates non-apoptotic cell death pathways, especially receptor-interacting protein (RIP) kinase-mediated necrosis, as key drivers of cone photoreceptor loss following rod degeneration. They also explore the roles of oxidative stress and microvascular dysfunction in disease progression, aiming to identify novel therapeutic targets for neuroprotection in RP and related retinal disorders.
Professor Xuchun Qiu's research lab specializes in environmental toxicology and nanomaterial safety, focusing on the impacts of emerging contaminants—such as pharmaceuticals, surfactants, heavy metals, and engineered nanoparticles—on aquatic organisms. The lab investigates the behavioral, physiological, and biochemical responses of fish, particularly zebrafish and medaka, to chronic and sublethal exposures, with an emphasis on neurotoxicity, oxidative stress, and neurotransmitter disruption. They also explore advanced materials for environmental remediation, including magnetic and imprinted photocatalysts for selective pollutant degradation.
Professor Roman Anufriev's research lab specializes in nanoscale thermal transport, focusing on ballistic and quasi-ballistic phonon dynamics in silicon-based nanostructures. The lab explores phononic crystals, nanopillars, and hole-array membranes to manipulate heat conduction through structural design, aiming to control thermal fluxes with high efficiency. Key research directions include engineering thermal conductivity in suspended nanostructures, developing novel concepts like ray phononics for directional heat flow, and advancing thermoelectric materials through nanostructuring. The lab combines experimental techniques such as time-domain thermoreflectance with theoretical modeling to uncover fundamental mechanisms and enable practical applications in thermal management and energy conversion.
