东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Kaori Hayashi's research lab focuses on the molecular mechanisms underlying kidney diseases, particularly glomerular podocyte dysfunction in chronic kidney disease (CKD). Her team investigates the roles of transcription factors like KLF4, DNA damage response pathways, and epigenetic regulation—such as DNA methylation—in podocyte maintenance and injury. The lab integrates molecular biology, metabolomics, and in vivo models to explore novel therapeutic targets for proteinuric kidney diseases and diabetic nephropathy.
Professor Cyrus Ghaznavi's research lab focuses on demographic and public health dynamics in Japan, with a particular emphasis on fertility trends, relationship formation, and the societal impacts of major disruptions such as the COVID-19 pandemic. The lab investigates how economic insecurity, changing relationship patterns, and health service interruptions influence reproductive behavior and sexual health across the life course. Key research directions include the decline in marriage and childbearing, rising rates of sexual inexperience among young adults, and the long-term implications for population aging and public health policy.
Professor Koki Nakanishi's research lab specializes in cardiovascular imaging and the pathophysiology of structural heart disease, with a focus on the role of visceral adipose tissue—particularly epicardial adipose tissue (EAT)—in the progression of coronary artery disease (CAD), atrial fibrillation, and heart failure. The lab employs advanced imaging modalities such as multidetector computed tomography (MDCT) and transthoracic echocardiography (TTDE) to investigate biomarkers of subclinical organ damage, including left atrial enlargement, coronary flow reserve, and cerebral small vessel disease. A key research direction involves understanding how metabolic and renal dysfunction, such as chronic kidney disease (CKD), interact with adipose tissue inflammation to accelerate cardiovascular and cerebrovascular pathology.
Professor Ryota Katsumi's research lab specializes in silicon quantum photonics, focusing on the hybrid integration of deterministic single-photon sources—particularly InAs/GaAs and InAs/InP quantum dots—onto silicon photonic integrated circuits (PICs). The lab pioneers transfer printing techniques to enable post-CMOS fabrication integration of III-V semiconductor quantum dots onto silicon platforms, overcoming material and process incompatibilities. Their work emphasizes scalable, high-efficiency, and unidirectional single-photon emission for large-scale quantum photonic integrated circuits, with applications in quantum communication and computing. They also explore diamond-based defects like nitrogen-vacancy centers for quantum sensing and memory, leveraging advanced nanofabrication.
Professor Kan Takase's research lab specializes in quantum optics and continuous-variable quantum technologies, focusing on the deterministic and high-rate generation of non-Gaussian quantum states such as optical Schrödinger cat states and Gottesman-Kitaev-Preskill (GKP) qubits. The lab develops innovative methods for quantum state engineering using photon detection, Gaussian operations, and waveguide-based optical parametric amplifiers to enable scalable, fault-tolerant quantum computation with light. A central theme is the realization of practical quantum information processing through advanced temporal waveform control and high-fidelity state synthesis.
Professor Haruki Watanabe's research lab focuses on the theoretical foundations of quantum many-body systems, with a central emphasis on topological phases, spontaneous symmetry breaking, and emergent quantum phenomena. The lab investigates the interplay between symmetry, topology, and electron correlations in condensed matter systems, particularly in magnetic materials, time crystals, and systems with nonsymmorphic symmetries. Key directions include the classification of band structures in magnetic space groups, the dynamics of Nambu-Goldstone modes in non-Lorentz-invariant systems, and the derivation of rigorous filling constraints for topological and band insulators. The lab employs advanced field-theoretic and group-theoretic methods to address fundamental questions in quantum matter.
Professor Naoji Matsuhisa's research lab specializes in the development of advanced functional materials for next-generation wearable and soft electronics. The lab focuses on creating stretchable, conductive, and mechanically resilient materials—such as elastic conductors, conductive hydrogels, and intrinsically stretchable transistors—enabling high-performance, conformable electronic devices. Key research directions include engineering printable inks, hybrid ion-electron conductors, and bioelectronic interfaces that combine high conductivity, stretchability, and biocompatibility. The lab’s work bridges materials science, electronics, and biomedical applications, with a strong emphasis on real-world usability and 'comfort-of-wear' in wearable technologies.
Professor Yuko Ono's research lab specializes in the fundamental characterization and functionalization of cellulose-based materials, with a focus on understanding their molecular structure, molecular weight distribution, and chemical modifications. The lab employs advanced analytical techniques such as size-exclusion chromatography with multi-angle light scattering (SEC-MALLS) and refractive index detection to study cellulose and its derivatives, including nanofibrillated and oxidized celluloses. Key research directions include the impact of chemical treatments—such as TEMPO oxidation and solvent exchange—on cellulose properties, as well as the development of analytical methods for precise determination of molar mass and functional group distribution. The work bridges materials science and analytical chemistry, contributing to sustainable biomaterials development.
Professor Yuki Okada's research lab focuses on epigenetic regulation, particularly the role of histone demethylases in development and disease, with a strong emphasis on spermatogenesis and male fertility. The lab investigates chromatin dynamics, including histone modifications and their reversibility, as well as the functional significance of non-coding RNAs such as sense-antisense transcripts. Additionally, the lab explores the molecular mechanisms underlying neurodegenerative diseases, especially Alzheimer’s disease, by studying amyloid-beta aggregation and its membrane-mediated toxicity. These interdisciplinary studies integrate molecular biology, genomics, and structural biology to uncover fundamental biological processes and their clinical implications.
Professor Yi Wan's research lab specializes in advanced composite materials, with a primary focus on carbon fiber-reinforced thermoplastics (CFRTPs) for lightweight automotive applications. The lab investigates the mechanical behavior, processing-structure-property relationships, and deformation mechanisms—such as springback and deconsolidation—of short and randomly oriented fiber composites. Using a combination of experimental testing, finite element analysis, and statistical modeling (e.g., Monte Carlo simulations), the lab develops predictive models for elastic properties and failure modes in complex geometries like L-shaped and hollow beams.
Professor Yusuke Adachi's research lab focuses on the molecular mechanisms underlying cellular stress responses, metabolic regulation, and the development of novel therapeutic agents for metabolic diseases such as diabetes and atherosclerosis. The lab investigates the unfolded protein response in the endoplasmic reticulum, the role of perivascular adipose tissue in vascular inflammation and remodeling, and the insulin-mimetic activities of vanadium-based complexes. A key direction involves the design and evaluation of bioactive metal complexes and photo-responsive molecules for potential medical applications.
Professor Shintaro Sengoku's research lab focuses on health innovation, particularly at the intersection of digital health, regulatory science, and biotechnology. The lab explores how machine learning and behavioral science can improve public health outcomes, such as increasing cancer screening rates, while also investigating the role of innovative financing mechanisms like social impact bonds. A key focus is on understanding how regulatory frameworks—such as Japan’s functional foods with claims (FFC) system—influence industry innovation and startup development. The lab also examines strategic alliances in biotech and digital health ecosystems to drive sustainable innovation in pharmaceutical development and medical technology.
Professor Hajime Yoshifuji's research lab specializes in autoimmune and systemic inflammatory diseases, with a focus on identifying novel biomarkers and developing targeted therapies for conditions such as polymyositis/dermatomyositis, lupus nephritis, IgG4-related disease, and large vessel vasculitides. The lab investigates the pathogenic roles of autoantibodies, cytokines like IL-6, and proteolytic enzymes such as calpain and osteopontin in disease progression and treatment response. A central theme is translating basic immunological findings into clinical applications, particularly through biologic agents and corticosteroid-sparing strategies.
Professor Ko Yamamoto's research lab specializes in interventional cardiology, with a primary focus on optimizing percutaneous coronary intervention (PCI) strategies to improve clinical outcomes in patients with complex coronary artery disease. The lab investigates the impact of intravascular ultrasound (IVUS) guidance, dual antiplatelet therapy (DAPT) duration, and vascular access routes on bleeding risk, stent restenosis, and major adverse cardiovascular events (MACCE). Key research directions include refining stent deployment techniques, personalizing DAPT duration based on bleeding risk, and comparing radial versus femoral access in high-bleeding-risk populations. The lab integrates clinical trial data with real-world practice to establish evidence-based, patient-tailored revascularization strategies.
Professor Yoshinori Akiyama's research lab focuses on the molecular mechanisms underlying protein quality control in the bacterial plasma membrane, particularly the roles of membrane-bound proteases such as FtsH, HtpX, and YaeL in maintaining cellular homeostasis. The lab investigates regulated intramembrane proteolysis, ATP-dependent degradation, and disulfide bond formation in the periplasm, with a central theme on how these systems ensure proper folding, assembly, and turnover of membrane and envelope proteins. Their work integrates biochemistry, genetics, and structural analysis to elucidate stress response pathways, including the Cpx and sigma^E systems, that safeguard membrane integrity under adverse conditions.
Professor Hitoshi Washizu's research lab specializes in computational materials science, focusing on the molecular-scale mechanisms of soft matter and interfacial phenomena. Key research directions include the design and simulation of advanced lubricants—such as graphene-iron composite particles and multilayered graphene transfer films—for ultralow friction applications. The lab also investigates ion and water transport in nanostructured materials like ionic liquid crystals and DNA-salt systems, using advanced simulation techniques including molecular dynamics, Monte Carlo, and coarse-grained modeling. Their work bridges fundamental understanding of nanoscale transport, electrostatics, and mechanical behavior with practical applications in energy efficiency, water treatment, and nanotribology.
Professor Yoshifumi Nakata's research lab specializes in quantum information theory and its applications to quantum many-body systems and fundamental physics. The lab explores quantum entanglement, quantum information scrambling, and the role of symmetry in quantum dynamics, particularly in the context of black hole physics and quantum chaos. A central theme is the development of information-theoretic tools—such as pseudo-entropy, decoupling protocols, and entanglement measures—to understand quantum correlations and information flow in complex quantum systems. The lab also investigates the feasibility of quantum error correction in realistic, short-depth quantum circuits, linking quantum information theory to quantum many-body phenomena and quantum gravity.
Professor Masaru Shibata's research lab specializes in numerical relativity and relativistic astrophysics, focusing on the dynamical processes of compact binary mergers—particularly neutron star-neutron star and black hole-neutron star systems. The lab conducts high-precision 3D simulations in full general relativity to study gravitational wave emission, post-merger remnant formation, and the conditions for short gamma-ray burst central engines. A central theme is the connection between numerical simulations and multi-messenger observations, such as those from GW170817, to constrain nuclear equations of state and neutron star properties.
Professor Keisuke Hagihara's research lab focuses on translational gerontology and integrative medicine, with a strong emphasis on aging-related diseases and their biological mechanisms. The lab investigates molecular pathways underlying sarcopenia, frailty, and neuroinflammatory conditions such as neuropathic pain, using both preclinical models and clinical studies. A key focus is on the therapeutic potential of traditional Japanese herbal medicines—particularly Go-sha-jinki-Gan (GJG)—in mitigating age-related muscle atrophy and chronic inflammation. The lab also explores lifestyle-based interventions, such as ketogenic diets, in the context of cancer and metabolic health, aiming to bridge basic science with patient-centered outcomes.
Professor Jun-Ping Du's research lab specializes in computational materials science, focusing on the atomic-scale design and optimization of advanced structural alloys, particularly Ni-based superalloys and medium/high-entropy alloys. The lab employs advanced simulation techniques—such as first-principles calculations, machine learning potentials, and accelerated molecular dynamics—to investigate defect engineering, chemical ordering, dislocation dynamics, and solute-defect interactions. Key research directions include understanding the role of refractory elements (e.g., Re, Ru, Co) in enhancing creep resistance and mechanical stability, as well as probing the thermodynamics and kinetics of local chemical order and phase stability in complex multicomponent systems.
