东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Yasushi Tsujimoto's research lab specializes in critical care and nephrology, with a focus on optimizing hemodialysis and continuous renal replacement therapy (CRRT) to improve patient outcomes. The lab investigates non-pharmacological interventions in critical care, including dialysate temperature, catheter design, and filter configuration, to prevent circuit coagulation and prolong treatment efficacy. Additionally, the lab conducts systematic reviews and meta-analyses on maternal and fetal health, particularly the long-term cardiovascular risks associated with preterm birth and low birth weight. Their work emphasizes rigorous methodology in diagnostic test accuracy and outcome reporting in clinical research.
Professor Alexis Vandenbon's research lab specializes in systems biology and computational genomics, focusing on deciphering gene regulatory networks and cellular responses in the immune system. The lab develops advanced bioinformatics methods to analyze single-cell and high-throughput gene expression data, with an emphasis on correcting batch effects, identifying differentially expressed genes without explicit clustering, and modeling transcriptional dynamics. Key research directions include understanding the interplay between transcription factors, epigenetic modifications, and gene expression during immune responses, particularly in dendritic cells and mouse immune cell types. The lab also constructs comprehensive coexpression databases to uncover conserved regulatory patterns across tissues and conditions.
Professor Masroor C. Pookkillath's research lab specializes in theoretical and mathematical cosmology, focusing on modified gravity theories that aim to address fundamental puzzles in modern cosmology, such as the Hubble tension and the nature of dark energy. The lab investigates minimally modified gravity models—including VCDM, f(ℋ) gravity, and massive gravity frameworks—exploring their implications for cosmic expansion, structure formation, and black hole collapse. A central theme is the study of new gravitational degrees of freedom, ghost and tachyonic instabilities, and the phenomenology of interacting dark sectors, particularly through vector and massive spin-2 fields. The lab combines analytical techniques with numerical simulations to test these models against observational data, including Planck and Pantheon datasets.
Professor Shinji Nishiwaki's research lab specializes in topology optimization and its applications in engineering design, focusing on structural mechanics, thermal management, and dynamic performance. The lab develops advanced optimization methodologies—such as homogenization and level-set methods—to design lightweight, high-performance structures with tailored mechanical, thermal, and vibrational characteristics. Key research directions include compliant mechanism design, eigenfrequency and eigenmode control in vibrating systems, and the optimization of passive heat sinks for natural convection cooling. The lab integrates high-fidelity multiphysics simulations with experimental validation to address real-world challenges in electronics, energy systems, and biomedical devices.
Professor Yukishige Ito's research lab specializes in the development of innovative synthetic methodologies for stereoselective glycosylation, with a primary focus on the challenging construction of 1,2-cis glycosidic linkages—particularly β-mannosides and other biologically relevant oligosaccharides. The lab pioneers advanced strategies such as intramolecular aglycon delivery (IAD), leveraging unique protecting group systems like p-methoxybenzyl (PMB) and naphthylmethyl (NAP) ethers to achieve high diastereoselectivity and yield. A key innovation is the use of polymer-supported glycosyl donors, where the polymer acts as a 'gatekeeper' to control reactivity and simplify purification, enabling efficient synthesis of complex glycoconjugates with minimal processing. The lab’s work has significant implications for the synthesis of natural glycans, including key motifs in N-linked glycoproteins.
Professor Kazuyo Moro's research lab focuses on the immunology of innate lymphoid cells (ILCs), particularly group 2 ILCs (ILC2s), with an emphasis on their development, differentiation, and roles in tissue homeostasis, metabolic disease, and fibrotic disorders. The lab investigates the signaling pathways, transcriptional regulation, and microenvironmental cues—including IL-7, Notch, and IL-33—that govern ILC lineage commitment and function. Using genetically modified mouse models and cellular immunology approaches, the lab explores how ILCs contribute to obesity, pulmonary fibrosis, and immune-mediated tissue repair.
Professor Shunbun Kita's research lab focuses on the molecular mechanisms underlying the protective roles of adiponectin and other secreted factors in metabolic and cardiovascular diseases. The lab investigates how adiponectin, an adipocyte-derived hormone, mediates organ protection through its interaction with T-cadherin, a unique cell surface receptor, and how this interaction regulates exosome biogenesis and ceramide metabolism. A central theme is the role of extracellular vesicles and protein-protein interactions in systemic metabolic regulation, with additional research on novel myokines such as musclin and their signaling through natriuretic peptide receptors. The lab combines biochemical, cell biological, and in vivo approaches to elucidate the pathophysiological functions of circulating factors in metabolism and vascular health.
Professor Yoshie Harada's research lab specializes in nanoscale biophysics and molecular recognition, focusing on understanding cellular heat transfer mechanisms and the dynamics of cytoskeletal proteins using advanced nanoscale imaging and sensing techniques. The lab develops and applies novel nanomaterials—such as fluorescent nanodiamonds and polyamide-based DNA binders—to probe intracellular thermal conductivity and sequence-specific DNA interactions with high spatial and temporal resolution. Their work bridges nanotechnology, cell biology, and biophysics to reveal fundamental mechanisms in cellular thermogenesis and gene regulation at the molecular level.
Professor Jinhua Dong's research lab specializes in the development of advanced biosensors and analytical technologies for biomedical and environmental applications. The lab focuses on innovative immunodetection systems, particularly Quenchbody (Q-body) and Ultra Quenchbody (UQ-body) platforms, which enable sensitive and selective detection of disease biomarkers such as HER2. Additionally, the lab investigates novel enzymes, including unique beta-agarases from marine bacteria, for biotechnological and industrial applications. The integration of molecular recognition, fluorescence quenching mechanisms, and protein engineering underpins the lab’s interdisciplinary approach to diagnostics and biocatalysis.
Professor Masahiro Asada's research lab specializes in semiconductor optoelectronics, focusing on the theoretical and experimental development of advanced laser structures and terahertz devices. Key research directions include quantum-confined semiconductor lasers—such as quantum dots, quantum wires, and quantum wells—where the lab investigates optical gain, polarization dependence, and threshold characteristics using advanced density-matrix theories with relaxation broadening. The lab also pioneers compact, room-temperature terahertz sources based on resonant tunneling diodes (RTDs) integrated with planar circuits, achieving record-high oscillation frequencies through innovative device design and loss reduction. Their work bridges fundamental semiconductor physics with practical applications in high-speed optical communications and terahertz technology.
Professor Junko N. Kondo's research lab specializes in the design and synthesis of advanced mesoporous metal oxides with tailored structures and functionalities for energy and environmental applications. The lab focuses on controlling the crystallization of amorphous mesoporous oxides while preserving their ordered nanostructure through templating and reinforcement strategies, enabling high-performance photocatalysts. A key research direction involves understanding surface reactions on metal oxide catalysts—particularly ZrO2—using in situ infrared spectroscopy to elucidate mechanisms of small molecule adsorption and surface transformation, such as CO, CO2, and H2. The ultimate goal is to develop efficient, stable, and selective catalysts for sustainable energy conversion, including water splitting and CO2 reduction.
Professor Hiromu Kashida's research lab specializes in the design and synthesis of novel artificial nucleic acids with tailored structural and functional properties. The lab focuses on developing acyclic scaffolds—particularly serinol and threoninol derivatives—to create DNA/RNA analogs that enable sequence-controlled chirality, enhanced stability, and the incorporation of functional molecules. Key research directions include photo-responsive DNA systems, such as those undergoing reversible [2+2] photocycloaddition for dynamic control of duplex stability, and the engineering of DNA-dye conjugates for optical signaling and sensing. The lab also pioneers molecular beacons and hybridization-based sensors with high specificity for single-nucleotide discrimination.
Professor Christian Leipe's research lab specializes in archaeobotany and bioarchaeology, focusing on the origins, spread, and ecological impacts of ancient crops in East Asia. The lab employs advanced radiocarbon dating and Bayesian statistical modeling to reconstruct the spatio-temporal dynamics of early agriculture, particularly millets, rice, and legumes. A key research direction involves linking plant domestication with prehistoric human population movements and cultural transitions, using high-precision dating of charred seeds and pollen from archaeological contexts. The lab also develops innovative microfluidic technologies for the high-throughput sorting of large biological particles, such as fossil pollen and microbeads, enabling detailed palaeoenvironmental and archaeobotanical analyses.
Professor Wataru Saito's research lab specializes in wide-bandgap semiconductor devices, with a primary focus on AlGaN/GaN high-electron-mobility transistors (HEMTs) for high-power and high-frequency electronics. The lab investigates advanced device structures—such as recessed-gate, dual-field plate, and optimized gate configurations—to achieve normally off operation, suppress current collapse, and enhance breakdown voltage and power efficiency. Their work emphasizes practical applications in power electronics, including motor drives and high-efficiency DC-DC converters, leveraging the unique material properties of GaN for next-generation power devices. The lab combines device simulation, process optimization, and experimental validation to address critical challenges in reliability and performance.
Professor Hemanta Hazarika's research lab specializes in geotechnical earthquake engineering with a focus on sustainable and low-cost seismic protection solutions using recycled materials, particularly scrap tire-derived products such as tire chips and shreds. The lab investigates the dynamic behavior of soil-structure systems under seismic loading, emphasizing liquefaction mitigation, energy dissipation, and improved foundation performance through innovative ground improvement techniques. Key research directions include large-scale shaking table testing, cyclic triaxial testing, and non-destructive evaluation of geosynthetic materials for infrastructure resilience.
Professor Jianjun Zhao's research lab specializes in software engineering with a focus on advanced programming paradigms and formal methods for ensuring software quality and maintainability. The lab explores cutting-edge areas such as quantum software engineering, aspect-oriented programming, program slicing, and architectural-level change impact analysis. Key research directions include developing formal models and static analysis techniques for concurrent and object-oriented systems, as well as innovative testing and verification approaches for emerging software architectures. The lab also investigates the intersection of software engineering with emerging technologies like quantum computing, aiming to build robust, scalable, and formally verified software systems.
Professor Tomomichi Kato's research lab specializes in terrestrial ecosystem ecology and biogeochemistry, with a focus on carbon and water cycles in mountainous and semi-arid ecosystems. The lab employs eddy covariance and remote sensing techniques to quantify carbon fluxes, ecosystem productivity, and evapotranspiration dynamics across diverse environments such as alpine meadows and savannas. Key research directions include carbon budget estimation, ecosystem modeling, and the integration of field observations with satellite data for improved environmental monitoring.
Professor Satoshi Shuto's research lab specializes in medicinal chemistry and natural product synthesis, with a focus on designing and synthesizing bioactive molecules inspired by natural products. Key research directions include the development of conformationally restricted peptidomimetics and cyclopropane-based scaffolds as potent NMDA receptor antagonists for neurological disorders, as well as the synthesis of novel nucleoside analogs with antiviral and anticancer potential. The lab also explores innovative synthetic methodologies, such as phospholipase D-catalyzed phosphorylation and phosphorus ylide-mediated carbon chain elongation, to enable efficient access to complex bioactive molecules.
Professor Tatsufumi Okino's research lab specializes in natural product chemistry, with a focus on the isolation, structural elucidation, and biological evaluation of bioactive compounds from marine and freshwater organisms. The lab investigates novel secondary metabolites such as cyclic depsipeptides, diterpene derivatives, and bromoallene-containing compounds, emphasizing their antifouling, enzyme inhibitory, and cytotoxic activities. A key research direction involves unraveling the enzymatic mechanisms behind complex biosynthetic modifications—particularly guanidine prenylation—using genetic and biochemical approaches to expand the toolbox for peptide engineering.
Professor Hidemichi Watari's research lab focuses on the molecular mechanisms underlying cancer progression, with a particular emphasis on tumor-intrinsic functions of immune checkpoint molecules such as PD-L1 and B7H3, as well as the regulatory roles of long non-coding RNAs like NEAT1. The lab investigates how these molecules contribute to epithelial-to-mesenchymal transition (EMT), cancer stem cell maintenance, metastasis, and therapy resistance. Additionally, the lab explores lipid metabolism and intracellular cholesterol trafficking, especially in the context of Niemann-Pick type C disease, to uncover links between cellular cholesterol homeostasis and tumorigenesis. These integrated studies aim to identify novel therapeutic targets and biomarkers for cancer diagnosis and treatment.
