东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Xinhao He's research lab specializes in seismic engineering with a focus on advanced structural systems for earthquake resilience. The lab investigates innovative isolation and damping technologies—such as rocking isolation bearings, friction pendulum systems, and base isolation with smart control—aimed at improving the seismic performance of bridges and buildings. A key research direction involves developing advanced monitoring and estimation techniques, including adaptive Kalman filtering and remote sensing-based damage assessment, to enable real-time structural health evaluation after seismic events. The lab also emphasizes the integration of sensor networks, system identification, and performance-based design to enhance the reliability and safety of civil infrastructure under extreme loading conditions.
Professor Masahiko Harata's research lab focuses on the molecular and cellular functions of actin-related proteins (ARPs), particularly their roles in chromatin dynamics, transcriptional regulation, and nuclear architecture. The lab investigates how ARPs, especially nuclear ARPs like Arp6 and human hArpN isoforms, contribute to chromatin remodeling complexes and epigenetic regulation in eukaryotes. Using genetic, biochemical, and genomic approaches in model systems such as *Saccharomyces cerevisiae* and *Caenorhabditis elegans*, the lab explores the structural and functional diversity of ARPs beyond canonical actin functions. Recent work also involves optimizing molecular tools, such as the AID2 system, for conditional protein degradation in live organisms to dissect ARP functions with high spatiotemporal precision.
Professor Teruko Takano-Yamamoto's research lab specializes in bone and periodontal tissue metabolism, with a focus on the molecular and cellular mechanisms underlying bone remodeling, particularly in the context of orthodontic tooth movement and hormonal regulation. Her work explores the roles of key regulators such as 1,25-dihydroxyvitamin D3, estrogen, and connective tissue growth factor (CTGF) in modulating osteoblast and osteoclast activity. The lab employs in vivo animal models, including rats, to investigate local signaling in alveolar bone and periodontal ligament, emphasizing mechanotransduction and gene expression in response to mechanical forces and hormonal stimuli. A central theme is understanding how systemic and local factors influence bone homeostasis in the craniofacial region.
Professor Masahiro Ayano's research lab focuses on the immunological mechanisms underlying systemic autoimmune diseases, particularly systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). The lab investigates complement system involvement, T cell and B cell pathogenesis, and novel biomarkers such as CD226+ immune cells to improve disease diagnosis, activity assessment, and treatment monitoring. A key research direction involves evaluating the efficacy and safety of immunomodulatory therapies, including hydroxychloroquine and autologous hematopoietic stem cell transplantation, with an emphasis on personalized treatment strategies.
Professor Satoshi Ichikawa's research lab specializes in natural product synthesis and drug discovery, with a focus on developing novel antibiotics targeting drug-resistant bacterial pathogens. The lab pioneers innovative synthetic methodologies—such as SmI2-promoted C-glycosidation—for constructing complex nucleoside antibiotics like herbicidin B and carbacaprazamycins. It also investigates the biological mechanisms of these compounds, including their unique modes of action on bacterial cell wall biosynthesis, and explores the detoxification of environmental toxins such as inorganic arsenic in edible seaweeds. The lab integrates total synthesis, mechanistic enzymology, and biological evaluation to advance new therapeutic agents.
Professor Masaru Koido's research lab specializes in computational and systems biology, focusing on integrating multi-omics data to decode complex biological mechanisms in disease, particularly cancer and drug response. The lab develops advanced machine learning and bioinformatics methods to interpret spatial transcriptomics, gene regulatory networks, and polygenic risk architectures underlying drug toxicity and tumor progression. Key research directions include predictive modeling of gene expression in spatial and pathological contexts, systems-level dissection of hypoxia and mitochondrial function in cancer, and improving genomic imputation for diverse populations. The lab bridges computational innovation with experimental validation to advance precision medicine and translational genomics.
Professor Masashi Sugiyama's research lab specializes in machine learning under non-stationary and real-world data conditions, with a strong focus on covariate shift adaptation, density ratio estimation, and supervised dimensionality reduction. The lab develops theoretically grounded and practical methods to address distributional shifts in input data, ensuring robustness in applications like classification, regression, and representation learning. A key contribution is the development of techniques such as local Fisher discriminant analysis and importance estimation for handling multimodal and non-i.i.d. data. The lab also explores applications in outlier detection, clustering, and conditional density estimation through the lens of density ratio estimation.
Professor Weiguang Cao's research lab specializes in theoretical high-energy physics and quantum field theory, with a focus on emergent symmetries, topological phases, and duality in condensed matter and quantum gravity systems. The lab explores non-invertible symmetries, subsystem symmetries, and their role in topological order, duality webs, and topological field theories. Key directions include lattice duality transformations, fermionization duality in (2+1)D, and the construction of symmetry-protected topological phases using generalized Jordan-Wigner and Kramers-Wannier transformations. The lab also investigates renormalization of effective field theories and the algebraic structures of defects and fusion rules in topological quantum field theories.
Professor Osamu Saitô's research lab specializes in polymer chemistry and radiation-induced reactions, focusing on the theoretical modeling of molecular weight distributions in irradiated polymers. The lab investigates complex processes such as cross-linking, cyclization, branching, and degradation, with particular attention to gelation kinetics and the role of end-linking probabilities. Additionally, the lab contributes to interdisciplinary studies in historical demography and urban-rural development, particularly in Sub-Saharan Africa and Japan, integrating quantitative methods with social science research. The work bridges physical chemistry with societal and demographic challenges through rigorous analytical and modeling approaches.
Professor Yoshihisa Asada's research lab specializes in high-redshift galaxy evolution, with a focus on star formation histories, galaxy mergers, and the interplay between star formation and intergalactic medium in the early Universe. Using advanced observational tools like the James Webb Space Telescope (JWST) and gravitational lensing, the lab investigates bursty star formation, metallicity evolution, and ionizing photon budgets in low-mass galaxies at cosmic dawn (z ∼ 4–7). The lab also develops novel theoretical models to correct for dust and neutral hydrogen attenuation in photometric redshift estimation, enhancing the accuracy of high-redshift galaxy surveys. Their work bridges deep imaging, spectroscopy, and theoretical modeling to understand the physical conditions and feedback mechanisms shaping the first galaxies.
Professor Masazumi Honda's research lab specializes in theoretical high-energy physics and mathematical physics, focusing on quantum field theories, string theory, and holography. The lab investigates supersymmetric gauge theories, Chern-Simons-matter systems like ABJM and its orbifolds, and their connections to topological strings and M-theory via advanced techniques such as the Fermi gas formalism. Key interests include exact non-perturbative results in quantum field theories, Borel summability of perturbative series, and the interplay between gauge theories, black hole entropy, and instanton effects.
Professor Kazutoshi Mori's research lab focuses on the molecular mechanisms underlying the unfolded protein response (UPR) in the endoplasmic reticulum (ER), a critical cellular stress response pathway. The lab investigates how misfolded proteins in the ER lumen activate signaling transducers such as ATF6 and XBP-1, leading to transcriptional reprogramming that restores ER homeostasis. Key research directions include the regulation of ER stress sensors, the role of post-translational modifications like disulfide bond formation in ATF6 activation, and the identification of cis-acting elements such as ERSE that control stress-responsive gene expression. The lab's work has significantly advanced understanding of ER stress signaling in health and disease, particularly in neurodegenerative and metabolic disorders.
Professor Akira Shinohara's research lab focuses on the molecular mechanisms underlying DNA double-strand break repair and meiotic recombination in eukaryotes. The lab investigates the distinct and cooperative roles of recombinase proteins such as Rad51 and Dmc1 in homologous recombination, with a particular emphasis on their regulation, structural dynamics, and functional interplay during meiosis. Key research directions include the regulation of sister chromatid cohesion, the role of cohesin and condensin complexes in chromosome dynamics, and the mechanisms of ssDNA annealing mediated by proteins like Rad52 and RPA. The lab integrates structural biology, biochemistry, and cell biology to elucidate fundamental processes in genome stability and inheritance.
Professor Daichi Amagata's research lab specializes in scalable data management and advanced analytics for large-scale, dynamic data environments, with a focus on spatial data streams, real-time pattern detection, and efficient query processing. The lab develops innovative indexing structures and algorithms—such as G2 for MaxRS monitoring and virtual point-based methods—for handling big data workloads in distributed and streaming settings. Key research directions include efficient outlier detection, clustering of high-dimensional data, and top-k query processing in distributed systems. The lab's work bridges theoretical algorithm design with practical applications in urban sensing, IoT, e-commerce, and social network analysis.
Professor Daisuke Inoue's research lab focuses on cellular and molecular mechanisms underlying bone metabolism, neuronal signaling, and ion channel regulation. The lab investigates how mechanical forces and biochemical signals regulate bone formation through transcription factors like FosB/DeltaFosB and explores the role of membrane proteins such as meltrin family members in bone cell function. Additionally, the lab examines signaling pathways in sympathetic neurons, particularly the GPR41-ERK1/2-synapsin 2 axis activated by short-chain fatty acids, and the impact of metabolites like palmitylcarnitine on cardiac ion channels. These studies integrate molecular biology, cell signaling, and physiology to uncover mechanisms relevant to bone diseases, neurological disorders, and cardiac dysfunction.
Professor Takashi Washio's research lab specializes in the integration of machine learning and experimental chemistry to accelerate discovery in synthetic organic chemistry and materials science. The lab focuses on developing intelligent screening strategies—particularly using Bayesian optimization and active learning—for complex multivariate reactions such as electrochemical transformations, organocatalysis, and flow chemistry. A key research direction involves enabling precise, single-molecule detection and analysis through machine learning-enhanced signal processing. The lab also pioneers data-driven discovery systems that extract meaningful chemical relationships from experimental data with high robustness and interpretability.
Professor Masatoshi Kondo's research lab specializes in advanced materials science for advanced nuclear energy systems, with a primary focus on corrosion resistance and material stability in liquid metal coolants such as lead-bismuth eutectic (LBE) and lithium lead (LiPb), as well as molten salts like Flibe. The lab investigates protective oxide layer formation, including α-Al₂O₃ and spinel-type γ-LiAlO₂, on advanced alloys such as ODS FeCrAl and Ni-based superalloys under extreme conditions relevant to fast breeder and fusion reactors. Their work combines thermodynamic analysis, static and flowing corrosion tests, and advanced characterization techniques like STEM/EELS to understand material degradation mechanisms and improve the longevity and safety of reactor components.
Professor Soshi Iimura's research lab specializes in the synthesis, characterization, and theoretical understanding of quantum materials, with a primary focus on iron-based superconductors and hydride ion conductors. The lab investigates electron and hydrogen/hydride doping effects in rare-earth and actinide-based compounds to explore unconventional superconductivity, magnetic order, and emergent electronic phenomena. A key direction involves using neutron scattering and transport measurements to probe spin fluctuations and Fermi surface topology, while another line of research targets the development of high-conductivity hydride materials for energy applications. The lab also explores defect engineering in transparent semiconductors to optimize electronic properties for next-generation optoelectronic devices.
Professor Mari Yotsu-Yamashita's research lab specializes in marine natural products chemistry, with a primary focus on the isolation, structural elucidation, and biosynthetic investigation of potent marine toxins—particularly tetrodotoxin (TTX) and saxitoxin analogs—found in pufferfish, amphibians, and marine invertebrates. The lab employs advanced analytical techniques such as LC-MS, NMR spectroscopy, and radio-ligand binding assays to study toxin structure-activity relationships, receptor interactions, and biosynthetic pathways. A key research direction involves identifying novel toxin derivatives and their precursors to unravel the enzymatic mechanisms behind toxin production in marine organisms.
Professor Erick Mas's research lab specializes in disaster risk reduction with a focus on tsunami hazard assessment, evacuation modeling, and post-disaster damage evaluation. The lab develops agent-based simulation models integrated with numerical tsunami simulations and geospatial data to estimate casualties and support emergency decision-making. It also conducts field surveys and leverages remote sensing, including satellite imagery and machine learning, to derive tsunami fragility curves for structural damage assessment. The lab’s work bridges engineering, data science, and emergency management to improve resilience in tsunami-prone regions.
