东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Akimasa Miyanaga's research lab specializes in the structural and biochemical characterization of enzymes involved in natural product biosynthesis, with a focus on glycoside hydrolases, polyketide synthases (PKSs), nonribosomal peptide synthetases (NRPSs), and related tailoring enzymes. The lab investigates enzyme mechanisms, substrate specificity, and protein-protein interactions, particularly in the context of complex natural products such as polyketide-amino acid hybrids, alkaloids, and phenolic lipids. Using X-ray crystallography, mutagenesis, and biochemical analyses, the lab uncovers molecular mechanisms underlying catalysis and recognition in these biocatalysts, contributing to synthetic biology and drug discovery.
Professor Satoshi Ansai's research lab specializes in functional genomics and genome editing in non-model vertebrates, with a primary focus on medaka fish (Oryzias latipes) as a vertebrate model. The lab develops and applies advanced genome editing technologies—such as CRISPR/Cas, TALENs, and ZFNs—to investigate gene function, genetic basis of phenotypic diversity, and mechanisms of reproductive isolation. Key research directions include targeted mutagenesis, cis-regulatory evolution, and the functional analysis of genes underlying sexually selected traits and adaptive evolution. The lab also pioneers high-throughput genotyping and mutation detection methods to support reverse genetics in vertebrate systems.
Professor Masahiro Yamada's research lab specializes in advanced functional materials and their applications in photonics, materials chemistry, and biomedical engineering. The lab focuses on the design and fabrication of novel functional materials such as periodically poled lithium niobate (LiNbO3) for electro-optic devices, spin-crossover complexes for smart materials with tunable magnetic and optical properties, and biocompatible bone substitutes for regenerative medicine. Key research directions include room-temperature domain engineering in ferroelectrics, molecular engineering of spin-crossover systems, and the development of multifunctional materials for optoelectronic and biomedical applications.
Professor Hisashi Aso's research lab focuses on the physiological and immunological roles of serotonin, particularly peripheral serotonin, in metabolic regulation and innate immunity. The lab investigates how serotonin influences glucose and lipid metabolism, energy expenditure, and insulin sensitivity, with implications for treating metabolic disorders such as obesity and type 2 diabetes. Additionally, the lab explores immunomodulatory mechanisms in bovine models, including the host response to bacterial pathogens in mastitis and the identification of mucosal immune markers in the gut-associated lymphoid tissue. These studies integrate molecular immunology, metabolism, and translational physiology to uncover novel therapeutic targets.
Professor Takeshi Nishimura's research lab specializes in active seismic monitoring and volcanic hazard assessment, focusing on the detection and analysis of seismic velocity changes, volcanic earthquake source mechanisms, and crustal deformation associated with volcanic and tectonic activities. The lab employs advanced seismic techniques—such as cross-spectrum analysis, moment tensor inversion, and distributed acoustic sensing (DAS)—to investigate subsurface processes in active volcanic regions like Iwate Volcano in Japan. A key research direction involves understanding how stress changes and magma dynamics influence seismic velocity and eruption probabilities following large earthquakes. The lab also explores the physical mechanisms of magma overpressure recovery after sudden depressurization, contributing to eruption forecasting and risk mitigation.
Professor Keisuke Kanayama's research lab specializes in combustion chemistry and reaction kinetics, with a strong focus on the pyrolysis and oxidation mechanisms of lithium-ion battery (LIB) electrolyte components. The lab investigates flammable carbonate esters—such as ethylene carbonate, dimethyl carbonate, and diethyl carbonate—using advanced experimental techniques like shock tubes, vacuum ultraviolet (VUV) spectroscopy, and photoion spectroscopy to understand their fire-risk behaviors. A key research direction involves developing detailed chemical kinetic mechanisms for LIB electrolyte surrogates, including the integration of fire-retardant additives like trimethyl phosphate (TMP). The lab also explores fundamental reaction pathways in hydrocarbon combustion, particularly the formation of aromatic rings and reactive intermediates.
Professor Kensaku Mori's research lab specializes in medical image computing, with a focus on 3D medical image analysis and computer-aided diagnosis systems. The lab develops advanced algorithms for automated anatomical labeling and bronchus extraction from 3D chest CT images, enabling applications in virtual bronchoscopy and lung cancer detection. Key research directions include image segmentation, region growing techniques, and knowledge-based anatomical labeling using rule-based systems. The lab's work bridges medical imaging and clinical decision support, aiming to improve diagnostic accuracy and efficiency in pulmonary disease assessment.
Professor Tomomi Kotani's research lab focuses on the molecular mechanisms underlying placental development and pregnancy complications, particularly preeclampsia. Her team investigates transcriptional regulators such as AP-2alpha and AP-2gamma in extravillous trophoblasts, exploring their roles in trophoblast migration and invasion. The lab also examines the impact of maternal mental health on perinatal outcomes, especially in well-controlled psychiatric conditions. These studies aim to uncover key regulatory pathways in placental function and improve maternal-fetal health.
Professor Hajime Kimizuka's research lab specializes in computational materials science, focusing on the atomic-scale understanding of elastic properties, diffusion mechanisms, and defect dynamics in advanced materials. The lab employs first-principles calculations and advanced molecular dynamics simulations—particularly path-integral and ab initio methods—to investigate quantum effects, phase transitions, and solute segregation in metals, oxides, and multicomponent alloys. Key research directions include hydrogen diffusion in iron-based systems, pressure-dependent elasticity in quartz, and the formation of complex atomic structures such as stacking faults and short-range order in alloy systems. The lab's work bridges theoretical modeling with experimental validation, contributing to the design of next-generation functional and structural materials.
Professor Syuhei Iguro's research lab focuses on new physics beyond the Standard Model, particularly in the context of flavor physics and lepton flavor universality violations observed in B-meson decays. The lab investigates extensions of the Standard Model such as two Higgs doublet models, models with right-handed neutrinos, and vector leptoquarks, aiming to explain anomalies in semileptonic B decays (e.g., R(D*), b→sμμ, b→cτν). They employ stringent flavor and electroweak precision constraints to test the viability of these models and explore their signatures at the LHC. The lab also studies the interplay between flavor-changing neutral currents, neutrino masses, and the phenomenology of heavy resonances.
Professor Yasuyuki Ohkawa's research lab focuses on the molecular mechanisms underlying skeletal myogenesis, particularly the transcriptional and epigenetic regulation governing muscle cell differentiation and maintenance in adults. The lab investigates the roles of key transcription factors such as MyoD and myogenin, as well as chromatin-remodeling complexes like SWI/SNF (Brg1-dependent), in orchestrating the gene expression programs essential for myogenic lineage commitment and terminal differentiation. Using developmental and cell culture models, the lab explores how transcription factors dynamically regulate their own expression and target genes through epigenetic modifications, providing insights into muscle development, regeneration, and potential therapeutic targets for myopathies. Their work bridges transcriptional regulation with chromatin dynamics, emphasizing the functional interplay between transcription factors and chromatin remodeling in cell fate determination.
Professor Vishwajit S. Chowdhury's research lab focuses on avian neuroendocrinology and metabolic physiology, with a primary emphasis on the regulation of reproduction, thermoregulation, and stress responses in poultry. The lab investigates neuropeptides such as gonadotropin-inhibitory hormone (GnIH) and neuropeptide Y (NPY), as well as amino acid metabolism—particularly citrulline and leucine—in modulating body temperature and adaptation to heat stress. Current research explores how environmental challenges like high ambient temperature affect physiological and metabolic functions in young chicks, aiming to improve poultry welfare and productivity under climate change conditions.
Professor Shusaku Asano's research lab specializes in microfluidics and chemical engineering, focusing on the fundamental mechanisms of mixing and reaction control in microreactors. The lab investigates how fluid dynamics—particularly vortices, fluid segment formation, and mixing history—affect reaction selectivity and efficiency in fast chemical reactions. Their work bridges computational fluid dynamics (CFD) simulations with experimental validation to optimize reactor design for applications in organic synthesis and biomass processing. A key focus is on developing predictive tools, such as effective Damköhler number models and scaling charts, to guide reactor design and temperature control.
Professor Yoshifumi Amamoto's research lab specializes in the design and synthesis of dynamic covalent polymers and functional materials, with a focus on self-healing, reconfigurable networks, and stimuli-responsive systems. The lab develops advanced polymer architectures—such as star-like nanogels and cross-linked networks—using dynamic covalent bonds like trithiocarbonate (TTC) and thiuram disulfide, enabling reversible bond exchange under mild conditions (e.g., visible light or heat). These systems are applied to create smart materials with self-healing, plasticity, and shape-memory properties, as well as to address challenges in epigenetics through site-selective chemical modification of chromatin. The lab bridges polymer chemistry, materials science, and chemical biology to create adaptive and functional materials with applications in biomedicine and advanced materials.
Professor Fumihiko Kinoshita's research lab specializes in clinical oncology and artificial intelligence in medicine, with a focus on improving prognostic prediction and personalized treatment strategies for non-small cell lung cancer (NSCLC). The lab integrates machine learning, particularly XGBoost, with comprehensive clinicopathological and laboratory data to develop predictive models for survival outcomes such as disease-free survival, overall survival, and cancer-specific survival. Key research directions include the prognostic significance of nutritional markers like serum albumin, histological subtypes (e.g., PST vs. ST adenocarcinoma), and the impact of postoperative changes in biomarkers. The lab also explores biological and clinical factors influencing patient outcomes, aiming to translate findings into practical clinical tools.
Professor Phongsaphak Sittimart's research lab specializes in the development and characterization of wide-bandgap semiconductor heterostructures, with a focus on diamond-based and gallium oxide (β-Ga₂O₃) heterojunction devices. The lab explores innovative heteroepitaxial growth techniques—such as RF magnetron sputtering and direct bonding—to fabricate high-performance Schottky diodes, p-n junctions, and photodetectors with exceptional thermal stability, radiation hardness, and rectifying performance. Key research directions include interface engineering, defect control via buffer layers, and the integration of novel materials like FeSi₂ and N-doped diamond for advanced optoelectronic and power electronic applications.
Professor Tsutomu Uchida's research lab specializes in the thermodynamics and kinetics of clathrate hydrates, particularly methane, carbon dioxide, and propane hydrates, under confined conditions such as in porous materials and natural sediments. The lab investigates how nano- and micro-confinement affect hydrate stability, phase equilibria, and interfacial properties using advanced experimental techniques like Raman spectroscopy, gas chromatography, and freeze-fracture transmission electron microscopy. A key focus is understanding the role of pore size and surface interactions in hydrate formation and decomposition, with applications in natural gas storage, carbon capture, and environmental science.
Professor Shin-ichiro Nishimura's research lab specializes in glycochemistry and glycomics, focusing on the development of innovative chemical and analytical methods for the selective manipulation and profiling of glycans from glycoproteins. The lab pioneers chemoselective derivatization techniques, such as solid-phase methyl esterification and isotope-coded labeling, to enable high-throughput, quantitative analysis of sialylated and other complex N-glycans. Their work bridges synthetic chemistry and systems biology, applying advanced mass spectrometry (e.g., MALDI-TOF/TOF) to study glycosylation changes in disease states, particularly in cancer and inflammatory conditions. The lab's contributions include establishing robust protocols for glycan release and purification, advancing the field of quantitative glycomics for biomarker discovery.
Professor Tomomi Nemoto's research lab specializes in advanced optical imaging technologies for live biological systems, with a focus on developing and applying innovative microscopy techniques to visualize dynamic cellular and neural processes in real time. The lab pioneers methods such as optical clearing for deep-tissue imaging, two-photon microscopy for high-resolution in vivo brain imaging, and intravital imaging of skin and pancreatic cells. Their work emphasizes understanding cellular dynamics—such as calcium signaling, actin reorganization, and mitotic division—within intact tissues and organs, particularly in the nervous system and epithelial tissues.
Professor Shogo Miyata's research lab specializes in regenerative medicine and bioengineering, focusing on the development of advanced three-dimensional tissue engineering systems using stem cells and decellularized extracellular matrices. The lab investigates mechanical stimulation and biomimetic microenvironments to enhance tissue maturation and function, particularly in skeletal muscle and cartilage regeneration. A key focus is on optimizing decellularization techniques using moderate high hydrostatic pressure to preserve native extracellular matrix integrity for use as functional scaffolds. The lab also develops innovative culture devices and bioreactors to study cell behavior under physiological mechanical cues, such as cyclic strain and compression, relevant to disease modeling and tissue repair.
