东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Atsuo T. Sasaki's research lab focuses on signal transduction mechanisms in cellular signaling pathways, particularly the regulation of receptor tyrosine kinases, cytokine receptors, and small GTPases such as Ras. The lab investigates negative feedback regulators like CIS3/SOCS3 and Sprouty proteins that fine-tune signaling outputs in hematopoietic and non-hematopoietic cells. Using biochemical, cell biological, and live-cell imaging approaches, the lab explores the spatiotemporal dynamics of key second messengers like PI(3,4,5)P3 and the roles of G proteins, PI3K, and their regulators in polarity and chemotaxis. A central theme is understanding how post-translational modifications—such as ubiquitination and phosphorylation—modulate oncoprotein activity and signal fidelity in development and disease.
Professor Naoto Shiraishi's research lab specializes in nonequilibrium statistical mechanics, quantum thermodynamics, and stochastic processes, with a focus on uncovering fundamental principles governing energy conversion, irreversibility, and information flow in classical and quantum systems. The lab investigates universal trade-offs between efficiency, power, and dissipation in thermodynamic processes, particularly in systems far from equilibrium, and develops theoretical frameworks such as fluctuation theorems, entropy production principles, and catalytic state transformations. A central theme is the interplay between information, entropy, and thermodynamic irreversibility, with applications to nanomachines, Maxwell's demons, and quantum many-body systems with nonthermal eigenstates. The lab also explores deep connections between quantum models like the PXP and AKLT Hamiltonians, revealing the role of symmetry in emergent non-equilibrium phenomena.
Professor Takuya Sasaki's research lab focuses on the dynamic interplay between neurons and glial cells in the brain, particularly in the hippocampus. The lab investigates how neuronal activity is modulated by astrocytes and how intracellular signaling pathways, such as those involving calcium and neurotransmitters, regulate action potential propagation and synaptic function. Using advanced techniques like functional multineuron calcium imaging, fluorescent patch-clamp, and optogenetics, the lab explores the mechanisms underlying spontaneous network activity, neuronal-glial communication, and neuroprotection in ischemic conditions. A central theme is understanding the role of glia not just as support cells, but as active participants in information processing and brain function.
Professor Germán Molpeceres' research lab specializes in astrochemistry and surface reaction dynamics, focusing on the formation mechanisms of key interstellar molecules under cold, low-density conditions typical of molecular clouds. The lab combines advanced computational methods—such as ab initio molecular dynamics and machine-learned interatomic potentials—with experimental validation to explore reaction pathways on interstellar dust grain analogs, particularly amorphous solid water. Major research directions include the formation of prebiotic molecules like formaldehyde, water ice, and sulfur-bearing species, with an emphasis on proton transfer, energy redistribution, and diffusion processes on icy grain surfaces. The lab also investigates the role of surface catalysis and isotope effects in astrochemical networks relevant to the origins of complex organic chemistry in space.
Professor Kazuma Mawatari's research lab specializes in advanced micro- and nanofluidic systems for single-particle and single-cell analysis, focusing on the manipulation and detection of ultrasmall liquid volumes (femtoliter to attoliter scale). The lab pioneers non-mechanical fluidic control technologies, such as the Laplace nanovalve, and develops ultrasensitive detection methods like thermal lens microscopy to enable individual particle counting in liquids. Their work bridges fundamental nanoscale fluidics with practical applications in clinical diagnostics and life sciences. The lab emphasizes the integration of analytical functions in microchips for high-efficiency, miniaturized diagnostic systems.
Professor Hideaki Yokoyama's research lab specializes in the design, synthesis, and characterization of advanced block copolymers for creating nanostructured materials with precise control over morphology and dynamics. The lab focuses on self-assembly phenomena in thin films and bulk materials, particularly the formation of ordered microdomains, nanocellular structures, and surface-segregated architectures using stimuli-responsive or selective solvents such as supercritical CO2. A key emphasis is placed on understanding and manipulating diffusion, phase behavior, and interfacial effects in asymmetric diblock copolymers to enable applications in nanofabrication, templating, and functional surface engineering.
Professor Shinjiro Takano's research lab specializes in the design, synthesis, and characterization of atomically precise gold and bimetallic clusters stabilized by organic ligands, with a focus on superatom chemistry and size-specific electronic properties. The lab explores the fundamental principles governing metal clusters through precise control of composition, doping (e.g., transition metals, hydrides), and geometry, enabling the creation of novel functional materials with tunable optical and electronic behaviors. Key advances include the development of phosphorescent superatoms, hydride-doped clusters, and bottom-up synthetic routes to complex bimetallic architectures.
Professor Akira Aoki's research lab specializes in laser applications in dentistry, with a primary focus on the therapeutic and clinical use of erbium-doped lasers (Er:YAG and Er,Cr:YSGG) for periodontal and endodontic treatments. The lab investigates the efficacy of laser irradiation in caries removal, subgingival calculus elimination, and periodontal tissue management, emphasizing minimal invasiveness, biocompatibility, and improved clinical outcomes. Research also explores the morphological and biological responses of root surfaces after laser treatment, particularly the impact on periodontal ligament cell attachment and tissue regeneration. The lab combines in vitro and clinical studies to optimize laser parameters for safe and effective use in oral soft and hard tissue procedures.
Professor Tomohiko Oka's research lab specializes in high-energy astrophysics, focusing on multi-messenger astronomy involving gamma rays, neutrinos, and cosmic rays. The lab investigates high-energy emission mechanisms in transient and persistent sources such as blazars, pulsars, and supernova remnants, with particular emphasis on diffusive shock acceleration and particle acceleration in extreme environments. Utilizing data from major observatories including Fermi-LAT, MAGIC, H.E.S.S., IceCube, and X-ray telescopes, the lab explores the connections between high-energy radiation and underlying astrophysical processes. Their work also includes detailed spectral and temporal analyses to constrain source distances, particle populations, and extragalactic background light effects.
Professor Sachiko Ono's research lab specializes in the fundamental mechanisms of self-organized anodic oxide nanostructures, particularly porous anodic alumina and magnesium oxides, with a focus on controlling pore morphology, ordering, and growth dynamics through electrochemical parameters. The lab investigates the role of electric field, current density, and interfacial reactions in achieving highly ordered nanoporous structures, and explores their transformation into stable, single-phase α-alumina membranes for advanced functional applications. Additionally, the lab contributes to biomedical research, particularly in vascular permeability and thyroid storm outcomes, reflecting a multidisciplinary approach bridging materials science and biomedicine.
Professor Yuanjun Zhu's research lab specializes in advanced fiber-optic devices and ultrafast laser systems, with a focus on tunable and multi-wavelength mode-locked fiber lasers. The lab pioneers innovative designs using Lyot filters, polarization-maintaining fibers, and thermal or mechanical tuning techniques to achieve dynamic wavelength control and dual-wavelength operation. Key research directions include the development of robust, all-fiber laser systems for applications in optical communications, terahertz wave generation, and dual-comb spectroscopy. The lab also investigates laser-induced damage mechanisms in ultrashort pulse systems, particularly for metallic mirrors used in high-intensity applications.
Professor Takashi Kikkawa's research lab specializes in spintronics and thermoelectric phenomena in magnetic materials, with a primary focus on the spin Seebeck effect (SSE) and its underlying mechanisms. The lab investigates longitudinal and transverse spin currents generated by thermal gradients, particularly in magnetic insulator/metal heterostructures such as Pt/YIG and Au/YIG, aiming to disentangle intrinsic spin effects from extrinsic contributions like the anomalous Nernst effect. Their work combines advanced experimental techniques with theoretical modeling, including Boltzmann transport and magnetoelastic coupling, to explore magnon dynamics, spin-phonon interactions, and the role of magnetic order in spin transport. The lab also contributes to fundamental understanding of spin-charge conversion and spin dynamics in quantum materials.
Professor Masamichi Zaizen's research lab specializes in theoretical and computational astrophysics, focusing on collective neutrino oscillations in extreme astrophysical environments such as core-collapse supernovae and binary neutron star mergers. The lab investigates the dynamics of fast neutrino-flavor conversion, multi-angle effects, and the interplay between neutrino self-interactions, matter effects, and angular distributions. Using advanced numerical simulations and stability analysis, the group explores how neutrino flavor evolution influences supernova explosion mechanisms, nucleosynthesis, and neutrino detection signatures.
Professor Muhammad Asad's research lab specializes in privacy-preserving machine learning, with a strong focus on Federated Learning (FL) for distributed and edge computing environments. The lab explores communication-efficient FL techniques, secure model aggregation, and privacy-enhancing technologies to address data security and scalability challenges in IoT, big data, and real-time applications. Key research directions include optimizing FL for resource-constrained edge devices, mitigating adversarial threats such as DDoS attacks in distributed systems, and enabling secure, decentralized AI training across smart devices and cloud infrastructures.
Professor Chikahiro Imashiro's research lab specializes in biomedical engineering with a focus on innovative cell culture technologies and their applications in regenerative medicine and cancer therapy. The lab develops advanced, non-invasive methods to control cell behavior—such as cell sheet fabrication, collective cell migration, and precise temperature regulation—for improved tissue engineering and therapeutic outcomes. Key research directions include the design of functional culture systems using metallic vessels and ultrasonic vibration to enable accurate thermal and mechanical stimulation of cells. The lab also investigates the thermal sensitivity of cancer cells to advance hyperthermia as a noninvasive cancer treatment strategy.
Professor Tadahisa Iwata's research lab specializes in the development of sustainable polymers and biobased materials, focusing on eco-friendly plastics derived from renewable resources. The lab investigates the synthesis and physical properties of novel polyesters and cellulose-based thermoplastics, particularly those incorporating functional groups like anthraquinone and cardanol derivatives to tailor thermal and solubility characteristics. A key research direction involves regioselective chemical modification of polysaccharides such as Curdlan and cellulose to create materials with enhanced performance for biomedical and environmental applications.
Professor Tomoyuki Morimae's research lab specializes in quantum information science, with a focus on secure and fault-tolerant quantum computing, measurement-based quantum computation, and quantum verification. The lab explores novel protocols for blind quantum computation, enabling clients with limited quantum capabilities to delegate quantum tasks to servers securely. Key research directions include topological quantum computation, continuous-variable quantum systems, and hypergraph states as universal resources for quantum computation.
Professor Sadat Mohamed Rezk Khattab's research lab specializes in synthetic biology and metabolic engineering of yeast and microbial systems to develop sustainable bioprocesses for high-value nutraceuticals, biofuels, and biochemicals. The lab focuses on enhancing microbial cell factories through genetic optimization—particularly in glycerol and pentose sugar utilization—enabling efficient conversion of renewable feedstocks like lignocellulosic biomass and biodiesel-derived glycerol into bioethanol, 2,3-butanediol, and functional food ingredients. A key research direction involves engineering osmotolerant and robust yeast strains, such as *Meyerozyma guilliermondii* and *Saccharomyces cerevisiae*, to improve productivity under industrial conditions.
Professor Naoyuki Amemiya's research lab specializes in electromagnetic field analysis and loss mechanisms in high-temperature superconducting (HTS) materials, particularly YBCO coated conductors. The lab focuses on numerical modeling using finite element methods to study AC losses, magnetization currents, and field quality in HTS tapes and coils, with applications in NMR magnets, power transmission cables, and superconducting devices. Key research directions include optimizing conductor geometry—such as striated multifilamentary structures and compact cable designs—to minimize losses under AC and transverse magnetic fields. The lab combines advanced numerical simulations with experimental validation to develop practical solutions for next-generation superconducting technologies.
Professor Yu Wang's research lab specializes in the theoretical and computational modeling of topological phenomena in quantum materials, with a focus on magnetic skyrmions and ferroelectric polarization structures. The lab investigates the stabilization, dynamics, and manipulation of these topological states under multi-field stimuli—such as electric fields, strain, temperature gradients, and mechanical stress—using advanced phase-field simulations based on Ginzburg-Landau theory. Key research directions include the design of zero-field skyrmions in multiferroic heterostructures, the engineering of topological polarization textures in ferroelectrics, and the thermomechanical control of skyrmion motion for next-generation spintronic devices.
