东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Hideyuki Mitomo's research lab specializes in nanomaterials and biomimetic nanostructures, focusing on the self-assembly of functional nanoscale systems with precise spatial and temporal control. Key research directions include the fabrication of 3D and 4D metal nanostructures using soft templates such as DNA brushes and hydrogels, as well as the development of stimuli-responsive plasmonic systems for tunable optical properties. The lab also investigates membrane interactions involving cholesterol derivatives and phospholipids, linking molecular-level dynamics to biological implications such as cytotoxicity and neurodegenerative diseases.
Professor S. Ted Oyama's research lab specializes in heterogeneous catalysis, with a focus on the development and characterization of advanced catalyst materials for environmental and energy applications. Key research directions include the synthesis and surface characterization of transition metal oxides, carbides, and nitrides, particularly for applications in pollution control and sustainable chemical processes. The lab employs advanced spectroscopic techniques such as laser Raman spectroscopy and oxygen chemisorption to understand surface chemistry and catalytic mechanisms at the molecular level. Their work also emphasizes the design of supported catalysts, including vanadium oxide on silica, to enhance activity and selectivity in industrial reactions.
Professor Yuki Muraoka's research lab specializes in retinal and choroidal imaging using advanced optical coherence tomography (OCT) techniques, with a focus on understanding the morphological and functional changes in retinal vascular diseases and degenerative conditions. The lab investigates pathological mechanisms in conditions such as central serous chorioretinopathy (CSC), branch retinal vein occlusion (BRVO), and retinal vascular tortuosity, emphasizing the role of structural changes in the retina and choroid. A key direction involves correlating OCT findings with visual outcomes to improve diagnosis and treatment strategies, particularly in macular edema and hemorrhagic complications. The lab also contributes to refining terminology and classification of retinal lesions, such as paravascular inner retinal defects (PIRD), for more precise clinical interpretation.
Professor Shigeo S. Kimura's research lab specializes in high-energy astrophysics, focusing on particle acceleration and emission processes in extreme astrophysical environments such as active galactic nuclei, compact binary mergers, and relativistic jets. The lab investigates the production of high-energy neutrinos, cosmic rays, and electromagnetic counterparts in connection with gravitational wave events and transient phenomena. Key research directions include stochastic and shear particle acceleration mechanisms, transrelativistic reacceleration in jet-cocoon systems, and the multi-messenger signatures of compact object mergers in AGN disks.
Professor Takuro Masumura's research lab specializes in the fundamental mechanisms of work hardening and phase stability in advanced steels, with a particular focus on high-nitrogen and metastable austenitic stainless steels. The lab investigates the roles of alloying elements such as carbon and nitrogen in influencing dislocation dynamics, martensitic transformation, and elastic stiffness. Using advanced characterization techniques—including modified Williamson-Hall and Warren-Averbach analyses—the lab uncovers the microstructural origins of high-strength and high-toughness behavior in engineering alloys. Their work bridges atomic-scale interactions with macroscopic mechanical properties, aiming to guide the design of next-generation high-performance steels.
Professor Hirofumi Kawakubo's research lab specializes in translational oncology, focusing on molecular mechanisms underlying breast cancer and esophageal squamous cell carcinoma (ESCC). The lab investigates tumor suppressor genes such as BTG2, exploring their roles in cell cycle regulation, apoptosis, and cancer progression. A key research direction involves evaluating pathological response and prognostic classification in patients receiving neoadjuvant chemotherapy, particularly DCF-based regimens in ESCC, to optimize treatment strategies. The lab integrates molecular pathology with clinical outcomes using real-world data to guide personalized cancer therapy.
Professor Kazuo Yonekura's research lab specializes in the integration of machine learning and physics-based modeling for engineering design and prediction, with a strong focus on aerodynamics, shape optimization, and uncertainty quantification. The lab develops advanced deep learning techniques—such as conditional GANs, VAE-WGAN hybrids, and physics-guided neural networks—to generate high-performance airfoil shapes and improve the reliability of short-term weather forecasts. A key research direction involves enhancing the physical consistency and interpretability of AI models through methods like Monte Carlo dropout for uncertainty estimation and guided training that embeds physical constraints without requiring gradient computation. The lab also emphasizes practical applications in energy management, transportation, and industrial design by leveraging data-driven approaches with robustness and generalization.
Professor Hiroshi Kitagawa's research lab specializes in the design and synthesis of porous coordination materials, particularly metal-organic frameworks (MOFs) and coordination polymers (CPs), with a focus on their applications in energy and electrochemical devices. The lab explores solid-state proton conductors, ionic liquid confinement in MOFs, and the rational engineering of framework structures to enhance ion transport and conductivity. Key research directions include the development of high-performance electrolytes for fuel cells, understanding proton conduction mechanisms via guest-host interactions, and controlling ion dynamics in nanoconfined environments. The lab combines advanced characterization techniques with theoretical analysis to achieve precise control over material functionality at the molecular level.
Professor Saeko Nakajima's research lab focuses on the immunological mechanisms underlying chronic inflammatory skin diseases, particularly atopic dermatitis and psoriasis. The lab investigates key immune regulators such as TSLP, PGI2-IP signaling, and microbiota-driven T cell responses to understand how innate and adaptive immunity shape barrier immunity and tissue inflammation. Using translational models and multi-omics approaches—including transcriptomics, proteomics, and lipidomics—the lab aims to uncover molecular pathways linking environmental triggers, immune cell activation, and disease pathogenesis. Their work highlights the role of stromal and dendritic cells in orchestrating type 2 and Th17-mediated inflammation at epithelial barriers.
Professor Keizō Tomonaga's research lab specializes in virology, with a focus on retroviruses and nonsegmented negative-sense RNA viruses, particularly feline immunodeficiency virus (FIV) and Borna disease virus (BDV). The lab investigates viral gene expression, regulatory mechanisms such as translational control and RNA splicing, and the development of viral vectors for stable gene delivery in the central nervous system. A key research direction involves understanding host-virus interactions, including the role of endogenous retroviruses in wild mouse populations and their genetic diversity.
Professor Nobuyoshi Yabuki's research lab specializes in Building Information Modeling (BIM) and digital infrastructure management, with a focus on developing standardized product models for civil engineering structures such as shield tunnels, bridges, and earthworks. The lab pioneers the extension of Industry Foundation Classes (IFC) to represent complex construction elements and processes, enabling interoperability across design, analysis, and construction software. Their work emphasizes data preservation, lifecycle management, and the integration of advanced technologies like VR, RFID, and 4D CAD for improved project control and on-site decision support.
Professor Suthee Ruangwises' research lab specializes in the design and analysis of physical zero-knowledge proof protocols for logic puzzles and combinatorial problems using everyday materials such as playing cards. The lab focuses on creating practical, human-verifiable cryptographic protocols that allow a prover to demonstrate knowledge of a solution without revealing any information, particularly in the context of pencil-and-paper puzzles like Shikaku, Five Cells, Meadows, Ball Sort Puzzle, and Makaro. A key direction involves developing general verification techniques for geometric and combinatorial constraints—such as rectangle area verification—enabling broader applications in secure, tangible computation. The lab also explores probabilistic models in matching problems, extending into random preference systems and their structural properties.
Professor Masanori Shigeno's research lab specializes in the development of innovative organic transformations, particularly focusing on C–H functionalization and selective C–C bond formation using transition metal and organocatalysis. The lab explores unique reactivity patterns, such as enantioselective reactions involving contradictory elementary steps and molecular switching in chiral helicene-based foldamers, revealing rich non-equilibrium thermodynamic behavior. A key theme is the design of catalytic systems—often involving alkali metal bases, fluoride sources, and phase-transfer catalysts—for the selective functionalization of heteroarenes and aliphatic systems.
Professor Kuniharu Takei's research lab specializes in the development of flexible, wearable electronic systems that mimic the functionality and adaptability of human skin. The lab focuses on creating multifunctional, skin-inspired devices for real-time health monitoring, point-of-care diagnostics, and human-machine interaction, with an emphasis on integrating sensing, actuation, and wireless communication. Key research directions include flexible sensors, printed electronics, and advanced materials such as SERS substrates and stretchable electronics for biomedical applications.
Professor Hironori Washizaki's research lab specializes in software engineering, with a focus on improving the design, reuse, and security of software systems. The lab explores patterns—particularly in IoT, machine learning, and security domains—to enhance system scalability, maintainability, and reusability. It also investigates advanced software architectures and aspect-oriented programming techniques to achieve better separation of concerns in modern web and component-based systems. The lab emphasizes practical adoption of patterns through systematic classification, modeling, and awareness-raising initiatives.
Professor Hidetoshi Sakurai's research lab specializes in stem cell biology and developmental signaling, with a focus on the molecular mechanisms governing cell fate decisions during embryonic development. The lab investigates key signaling pathways—such as Activin, BMP, Wnt, and growth factors like HGF and TGF-β—that regulate endothelial and mesodermal lineage differentiation from pluripotent stem cells. Using both embryonic and induced pluripotent stem cells (iPS), the lab explores tissue morphogenesis, particularly in kidney and muscle development, and examines environmental stressors like oxidative stress in disease contexts such as facioscapulohumeral muscular dystrophy (FSHD). Their work bridges developmental biology with regenerative medicine and disease modeling.
Professor Koji Oohora's research lab specializes in bioinorganic chemistry and supramolecular protein engineering, focusing on the design and functional characterization of artificial metalloenzymes through cofactor substitution in hemoproteins. By replacing native heme with synthetic porphyrin-based metal complexes—such as manganese and iron porphycenes—the lab develops novel biocatalysts with tailored reactivity, including C–H hydroxylation and cyclopropanation. The group combines X-ray crystallography, spectroscopy, and kinetic studies to elucidate reaction mechanisms and protein–cofactor interactions, while also exploring the self-assembly of functional protein architectures via engineered cofactor-protein and protein-ligand interactions. Their work bridges synthetic biology, inorganic chemistry, and materials science to create functional biomolecular systems with applications in catalysis and nanomaterials.
Professor Takuya Ishikawa's research lab specializes in advanced endoscopic diagnostics and pancreatic disease pathology, with a strong focus on improving the accuracy and safety of tissue diagnosis in autoimmune pancreatitis (AIP) and other pancreatic disorders. The lab pioneers the application of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using innovative needles like the 22-gauge Franseen needle, aiming to enhance histological diagnosis and reduce reliance on serological markers. A key innovation involves integrating artificial intelligence—particularly deep learning and contrastive learning—into the analysis of EUS-FNB specimens to support real-time, objective diagnostic evaluation. The lab also investigates metabolic regulation in skeletal muscle, particularly the role of branched-chain amino acids (BCAAs) in mTORC1 signaling and protein metabolism under varying dietary conditions.
Professor Yutaka Kondo's research lab specializes in cancer epigenetics, focusing on the molecular mechanisms underlying epigenetic regulation in tumorigenesis. The lab investigates how long non-coding RNAs (lncRNAs), histone modifications, and DNA methylation interplay to maintain cancer stemness and drive tumor progression. Key research directions include the role of lncRNA TUG1 in glioma stem cells through miRNA sponging and epigenetic silencing, as well as the functional contributions of histone methyltransferases like G9a and SUV39H1 in maintaining malignant phenotypes. The lab also explores epigenetic crosstalk between DNA methylation and histone modifications, aiming to identify novel therapeutic targets in cancer.
Professor Masaru Kato's research lab specializes in bio-hybrid materials and sustainable energy conversion, focusing on integrating biological components such as Photosystem II and enzymes with functional materials for applications in renewable energy and analytical chemistry. Key research directions include protein film photoelectrochemistry, bio-inspired water oxidation, and the development of sol-gel-encapsulated enzyme systems for miniaturized bioreactors and chiral separations. The lab pioneers innovative immobilization strategies using nanostructured electrodes and sol-gel matrices to enhance electron transfer efficiency and enzyme stability.
