探索全球顶尖大学的研究室——研究领域与主要论文一览无余。
Professor János Szebeni's research lab focuses on the immunological and physiological mechanisms underlying hypersensitivity reactions triggered by nanomedicines, particularly those involving polyethylene glycol (PEG)-coated nanoparticles and liposomal formulations. The lab investigates complement activation as a central driver of acute, pseudoallergic reactions—termed CARPA (complement activation-related pseudoallergy)—and explores the role of anti-PEG antibodies in accelerating drug clearance and causing severe adverse events. Using large animal models such as pigs, dogs, and rats, the lab develops and validates preclinical models to study and predict cardiopulmonary and systemic side effects of nanotherapeutics.
Professor Hyung-Mun Yun's research lab focuses on neuropharmacology and molecular mechanisms underlying neurological and neuroinflammatory diseases, with a central emphasis on serotonin receptors—particularly the 5-HT6 receptor—as therapeutic targets for Alzheimer’s disease and depression. The lab investigates cell signaling pathways, glial cell modulation, and the role of endogenous antioxidants such as peroxiredoxin 6 in neurodegenerative and autoimmune disorders like multiple sclerosis. Additionally, the lab explores the use of functional biomaterials, including magnetic nanocomposite scaffolds, for tissue engineering and regenerative medicine. Their work bridges molecular neuroscience, neuroimmunology, and translational therapeutics.
Professor Takeshi Kondo's research lab specializes in quantum materials, focusing on the electronic structure and emergent quantum phenomena in high-temperature superconductors, topological materials, and strongly correlated systems. Using advanced angle-resolved photoemission spectroscopy (ARPES) combined with first-principles calculations, the lab investigates unconventional superconductivity, pseudogap physics, and exotic quantum states such as nodal superconductors and topological semimetals. A central theme is understanding the interplay between electron correlation, spin-orbit coupling, and symmetry-protected topological order in iron-based and 5d iridate systems.
Professor Ichiro Hisaki's research lab specializes in the design and synthesis of porous hydrogen-bonded organic frameworks (HOFs) with a focus on enhancing their thermal and chemical stability while achieving high surface areas and permanent porosity. The lab pioneers the use of shape-persistent, C3-symmetric π-conjugated macrocycles and functionalized hexaazatriphenylene derivatives as robust molecular tectons to construct crystalline frameworks through reversible hydrogen bonding. By combining single-crystal X-ray diffraction, gas sorption, and ultrafast spectroscopy, the lab enables precise structural characterization and functional evaluation of these materials, particularly for applications in gas storage, sensing, and photoresponsive materials. The research emphasizes the rational engineering of supramolecular synthons and network topology to overcome common challenges such as framework interpenetration and structural collapse.
Professor Hiroaki Sasai's research lab specializes in the development of asymmetric catalysis using rare-earth-based multifunctional complexes. The lab pioneers the design of heterobimetallic catalysts that simultaneously exhibit both Lewis acidity and Brønsted basicity, mimicking enzymatic functions to achieve high enantioselectivity in carbon-carbon and carbon-nitrogen bond-forming reactions. Key research directions include catalytic asymmetric nitroaldol reactions and the structural optimization of rare-earth–alkali metal complexes with chiral ligands such as BINOL derivatives. Their work has led to significant advances in enantioselective synthesis, offering synthetic alternatives to enzyme-catalyzed transformations.
Professor Youngbin Yoon's research lab specializes in combustion science and fluid dynamics, with a focus on turbulent non-premixed jet flames, particularly those involving hydrogen and syngas (H₂/CO) fuels. The lab investigates fundamental combustion phenomena such as flame blowout limits, flame stabilization, and NOx emissions under various flow and injection conditions. Key research directions include the effects of orifice internal flow on liquid jet breakup, flame dynamics in supersonic crossflows, and the scaling of NOx emissions based on residence time and fuel composition. The work has strong applications in gas turbine and combustor design, aiming to improve efficiency and reduce emissions.
Professor Kwanjung Yee's research lab specializes in aerospace and aeronautical systems, with a focus on advanced aerodynamic design, flight vehicle performance optimization, and uncertainty quantification in unmanned aerial vehicles and hypersonic vehicles. The lab conducts computational and numerical studies on rotorcraft aerodynamics, multirotor UAV design for mission-specific performance, snow accumulation in high-speed train environments, and wake vortex dynamics. It also pioneers innovative design methodologies for waverider configurations using direct optimization frameworks based on shockwave physics.
Professor Myeong Hee Moon's research lab specializes in advanced analytical methodologies for the separation, characterization, and proteomic analysis of biological nanoparticles and lipid species. The lab focuses on developing and applying innovative hyphenated techniques—such as field-flow fractionation (FlFFF), nanoflow liquid chromatography, ion mobility spectrometry, and tandem mass spectrometry—to study subcellular organelles, extracellular vesicles, and phospholipids with high resolution and sensitivity. Key research directions include the size-based separation of mitochondria and starch granules, the proteomic profiling of extracellular vesicles, and the structural characterization of phospholipids and lysophospholipids in complex biological matrices.
Professor Dong-Sik Kim's research lab specializes in nanomaterials synthesis and characterization, with a focus on carbon-based nanomaterials such as single-walled carbon nanotubes and zinc oxide nanowires. The lab explores advanced fabrication techniques like laser-interference lithography and chemical vapor transport to create highly ordered nanostructures with tailored optical and electronic properties. Additionally, the lab investigates functional hybrid nanomaterials, including gold nanoparticle-decorated carbon nanotubes, for potential applications in biomedicine and sensing. A parallel research direction involves the behavioral and psychological impacts of adolescent risk behaviors, particularly their links to mental health outcomes.
Professor Hyung Joon Yim's research lab focuses on viral hepatitis, particularly chronic hepatitis B (HBV) and its complications such as hepatocellular carcinoma (HCC). The lab investigates the molecular mechanisms of HBV persistence, drug resistance, and host immune responses, with an emphasis on optimizing antiviral therapy and clinical management. It also explores gut-liver axis alterations in acute-on-chronic liver failure and the role of microbiota in liver disease progression. The lab contributes to evidence-based clinical guidelines and translational research to improve outcomes in liver disease.
Professor Klaus Heese's research lab focuses on neuroinflammation and neurotrophin biology in the context of neurodegenerative diseases, particularly Alzheimer’s disease. The lab investigates microglial activation, neurotrophin signaling (especially NGF), and the molecular mechanisms underlying neuronal survival and degeneration. In parallel, the lab explores sustainable biotechnological applications, including the discovery of novel enzymes from marine microorganisms and the green synthesis of silver nanoparticles using seaweed-derived biomolecules. These interdisciplinary efforts bridge neuroscience, molecular immunology, and environmental biotechnology.
Professor Byungmin Kim's research lab specializes in earthquake engineering and geotechnical earthquake engineering, with a focus on site response analysis, soil-structure interaction, and seismic hazard assessment. The lab investigates dynamic soil behavior using downhole array recordings, particularly from long-duration subduction zone earthquakes, and develops advanced methods for estimating site parameters such as VS30 using seismic wave characteristics. A key emphasis is placed on understanding the effects of basin geometry, liquefaction potential, and local site conditions on structural damage and ground motion amplification.
Professor Myong-In Lee's research lab specializes in atmospheric and climate dynamics, with a focus on tropical and mid-latitude weather systems, including the Madden-Julian Oscillation, intraseasonal variability, heat waves, and the diurnal cycle of precipitation. The lab investigates the roles of moisture advection, cloud-radiation interactions, and land-atmosphere feedbacks in shaping regional and global climate patterns, using advanced general circulation models and data assimilation techniques. A key emphasis is placed on improving the simulation of atmospheric processes through high-resolution modeling and satellite soil moisture assimilation. The lab also explores the impacts of climate variability on extreme weather events in East Asia and North America.
Professor Sang Youl Rhee's research lab focuses on metabolic and vascular complications associated with diabetes mellitus, particularly the role of advanced glycation end-products (AGEs) in disease progression. The lab investigates biomarkers such as glutamine and glutamic acid for early detection of diabetic retinopathy, explores the link between diabetes and neurodegenerative conditions like Parkinson’s disease, and examines the impact of environmental factors—such as blood lead levels—on metabolic syndrome. The research integrates clinical epidemiology with molecular mechanisms to identify novel risk factors and early diagnostic indicators in type 2 diabetes and its complications.
Professor Yusuke Hirabayashi's research lab focuses on cellular and subcellular mechanisms underlying neural development, organelle communication, and calcium signaling in neurons. The lab investigates how signaling pathways such as Wnt/β-catenin regulate neural precursor cell fate decisions and neuronal differentiation, while also exploring the functional roles of inter-organelle contact sites—particularly endoplasmic reticulum–mitochondria contacts—in calcium homeostasis and neuronal plasticity. Using advanced imaging, optogenetics, and deep learning-based image analysis, the lab aims to uncover the dynamic, 3D organization of cellular structures and their roles in brain development and function.
Professor Ryohei Terauchi's research lab specializes in plant genomics and molecular breeding, focusing on the genetic mechanisms underlying disease resistance in crops—particularly rice. The lab develops and applies next-generation sequencing (NGS)-based technologies such as MutMap and MutMap-Gap to rapidly identify causal mutations and resistance genes, enabling precise and efficient crop improvement. Their work integrates functional genomics, pathogen–host interaction studies, and high-throughput gene expression analysis to dissect complex traits and evolutionary dynamics in plant-pathogen systems. The lab also pioneers innovative sequencing methods like SuperSAGE to profile host and pathogen gene expression simultaneously during infection.
Professor Naoto Katakami's research lab specializes in cardiovascular complications of diabetes, with a focus on diabetic macroangiopathy and its underlying vascular pathophysiology. The lab investigates vascular imaging biomarkers—such as carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV)—to improve risk stratification and monitor disease progression in diabetic patients. Key research directions include evaluating the efficacy of pharmacological agents like cilostazol and tofogliflozin in slowing atherosclerotic progression and assessing soluble RAGE (esRAGE) as a potential circulating marker of vascular damage. The lab integrates clinical trials with advanced vascular imaging to translate findings into practical tools for cardiovascular risk management in diabetes.
Professor Kenji Inaba's research lab specializes in the molecular mechanisms of disulfide bond formation and redox regulation in biological systems, with a focus on protein folding, oxidative folding pathways, and metal ion homeostasis in cellular compartments. The lab investigates key enzymes such as DsbB and ERp44, exploring their roles in disulfide bond catalysis, electron transfer, and metal ion sensing—particularly zinc. Using structural biology, biochemistry, and spectroscopic techniques, the lab uncovers how redox enzymes function under physiological conditions and how their activity is modulated by cofactors and metal ions. These studies provide fundamental insights into protein quality control and have implications for diseases involving misfolded proteins and redox imbalance.
Professor Hiroshi Kimura's research lab specializes in the virology and immunopathology of Epstein-Barr virus (EBV), with a focus on chronic active EBV infection (CAEBV) and EBV-associated lymphoproliferative disorders. The lab investigates the molecular mechanisms underlying EBV persistence, clonal expansion of infected T or natural killer (NK) cells, and the clinical and virological features that drive disease progression. Using advanced molecular techniques such as real-time quantitative PCR, the lab quantifies viral load and explores host-virus interactions to identify prognostic markers and therapeutic targets. Their work also contributes to understanding the epidemiological and clinical differences in EBV-related diseases across populations, particularly in Asian and nonimmunocompromised cohorts.
Professor Fumina Tanaka's research lab specializes in food science and engineering, focusing on the development of bio-based edible coatings and active packaging materials to enhance food preservation and quality. The lab investigates the physicochemical and antifungal properties of natural polymer-based films enriched with essential oils and nanomaterials, particularly for perishable fruits like strawberries and stone fruits. Additionally, the lab conducts advanced thermal and drying process analyses to optimize the preservation of rice-based animal feed and understand the impact of thermal treatment on nutrient retention and structural properties of agricultural products. Their work integrates computational modeling, X-ray computed tomography, and experimental drying studies to support sustainable food processing solutions.
