Bit-nae Kim
Seoul National University · Biochemistry, Genetics and Molecular Biology
About the Lab
Professor Bit-nae Kim's research lab specializes in RNA biology, focusing on the molecular mechanisms underlying post-transcriptional gene regulation. The lab investigates non-coding RNAs, including microRNAs and novel small RNAs, with an emphasis on their biogenesis, function, and roles in development and disease. Key research directions include the regulation of mRNA stability and translation through RNA modifications—such as guanylation of poly(A) tails—and the systems-level analysis of transcriptomic and epitranscriptomic dynamics in neurobiology and viral infection. The lab also develops advanced sequencing technologies to enable accurate quantification of small RNAs and high-resolution mapping of viral and cellular transcriptomes.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15microRNAs (miRNAs) play integral roles in diverse processes including tumorigenesis. miRNA gene loci are often found in close conjunction, and such clustered miRNA genes are transcribed from a common promoter to generate polycistronic primary transcript. The primary transcript (pri-miRNA) is then processed by two RNase III proteins to release the mature miRNAs. Although it has been speculated that the miRNAs in the same cluster may play related biological functions, this has not been experimenta
Research Areas
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