Skip to main content

Bo La Yun

Seoul National University · Medicine

About the Lab

Professor Bo La Yun's research lab specializes in medical imaging and targeted cancer theranostics, with a focus on improving breast cancer detection and treatment through advanced imaging techniques and nanotechnology. The lab investigates dynamic contrast-enhanced MRI perfusion parameters to correlate with breast cancer subtypes and prognosis, while also exploring novel contrast agents and drug delivery systems such as trastuzumab-conjugated liposomes for HER2-positive breast cancer. Additionally, the lab evaluates diagnostic accuracy in breast ultrasound and MRI, emphasizing computer-aided diagnosis and the differentiation of challenging brain lesions using multimodal imaging.

breast cancer imagingDCE-MRInanoparticle drug deliverytargeted therapycomputer-aided diagnosis

Research Overview

Papers
88
Total Citations
1,875
Papers (5y)
13
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
13total
2022
2023
2024
2025
2026
Citations per year (5y)
81total
20222023202420252026

Selected Papers

15
1
Article|171 citations·2013
Breast Cancer Detected with Screening US: Reasons for Nondetection at Mammography
Min Sun Bae, Woo Kyung Moon, Jung Min Chang, Hye Ryoung Koo, Won Hwa Kim, Nariya Cho, Ann Yi, Bo La Yun, Su Hyun Lee, Mi Young Kim, Eun Bi Ryu, Mirinae Seo
SJR Q1Radiology

Most breast cancers (81%) detected at screening US were not seen at mammography, even in retrospect. In addition, 19% had subtle or evident findings missed at mammography.

Pulmonary and Respiratory MedicineMedicine
2
Article|164 citations·2009
Distinguishing Tumefactive Demyelinating Lesions from Glioma or Central Nervous System Lymphoma: Added Value of Unenhanced CT Compared with Conventional Contrast-enhanced MR Imaging
Dae Sik Kim, Dong Gyu Na, Keon Ha Kim, Ji‐hoon Kim, Eunhee Kim, Bo La Yun, Kee‐Hyun Chang
SJR Q1Radiology

Unenhanced CT plus MR imaging was more accurate for distinguishing TDLs from glioma or CNS lymphoma than contrast-enhanced MR imaging alone.

GeneticsMedicine
3
Article|147 citations·2012
Correlation of perfusion parameters on dynamic contrast‐enhanced MRI with prognostic factors and subtypes of breast cancers
Hye Ryoung Koo, Nariya Cho, In Chan Song, Hyeonjin Kim, Jung Min Chang, Ann Yi, Bo La Yun, Woo Kyung Moon
SJR Q1Journal of Magnetic Resonance Imaging

PURPOSE: To investigate whether a correlation exists between perfusion parameters obtained from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and prognostic factors or immunohistochemical subtypes of breast cancers. MATERIALS AND METHODS: Quantitative parameters (K(trans) , k(ep) , and v(e) ) of 70 invasive ductal carcinomas were obtained using DCE-MRI as a postprocessing procedure. Correlations between parameters and prognostic factors, including tumor size, axillary nodal st

Radiology, Nuclear Medicine and ImagingMedicine
4
Article|90 citations·2019
A computer-aided diagnosis system using artificial intelligence for the diagnosis and characterization of breast masses on ultrasound
Hee Jeong Park, Sun Mi Kim, Bo La Yun, Mijung Jang, Bohyoung Kim, Ja Yoon Jang, Jong Yoon Lee, Soo Hyun Lee
SJR Q3MedicineOA

To evaluate the value of the computer-aided diagnosis (CAD) program applied to diagnostic breast ultrasonography (US) based on operator experience.US images of 100 breast masses from 91 women over 2 months (from May to June 2015) were collected and retrospectively analyzed. Three less experienced and 2 experienced breast imaging radiologists analyzed the US features of the breast masses without and with CAD according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon and categorie

Artificial IntelligenceComputer Science
5
Article|85 citations·2011
Sonoelastography for 1786 non-palpable breast masses: diagnostic value in the decision to biopsy
Ann Yi, Nariya Cho, Jung Min Chang, Hye Ryoung Koo, Bo La Yun, Woo Kyung Moon
SJR Q1European Radiology
Radiology, Nuclear Medicine and ImagingMedicine
6
Article|60 citations·2018
Prediction of Subclinical Coronary Artery Disease With Breast Arterial Calcification and Low Bone Mass in Asymptomatic Women
Yeonyee E. Yoon, Kyoung Min Kim, Jong Soo Han, Si‐Hyuck Kang, Eun Ju Chun, Soyeon Ahn, Sun Mi Kim, Sang Il Choi, Bo La Yun, Jung‐Won Suh
SJR Q1JACC. Cardiovascular imaging
Radiology, Nuclear Medicine and ImagingMedicine
7
Article|58 citations·2014
Trastuzumab-Conjugated Liposome-Coated Fluorescent Magnetic Nanoparticles to Target Breast Cancer
Mijung Jang, Young Il Yoon, Yong‐Su Kwon, Tae‐Jong Yoon, Hak Jong Lee, Sung Il Hwang, Bo La Yun, Sun Mi Kim
SJR Q1Korean Journal of RadiologyOA

Trastuzumab-conjugated Lipo[MNP@m-SiO2] is a potential treatment tool for targeted drug delivery in Her2/neu-positive breast cancer.

BiomaterialsMaterials Science
8
Article|57 citations·2018
Benign Intraductal Papilloma without Atypia on Core Needle Biopsy Has a Low Rate of Upgrading to Malignancy after Excision
Song-Hee Han, Milim Kim, Yul Ri Chung, Bo La Yun, Mijung Jang, Sun Mi Kim, Eunyoung Kang, Eun‐Kyu Kim, So Yeon Park
SJR Q2Journal of Breast CancerOA

The rate of upgrading to malignancy for benign IDP without atypia was very low, suggesting that close clinical and radiologic observation may be sufficient for patients with benign IDP without atypia on CNB under proper settings.

Pathology and Forensic MedicineMedicine
9
Article|52 citations·2019
Benign Breast Papilloma without Atypia: Outcomes of Surgical Excision versus US-guided Directional Vacuum-assisted Removal or US Follow-up
Hye Young Choi, Sun Mi Kim, Mijung Jang, Bo La Yun, Eunyoung Kang, Eun‐Kyu Kim, So Yeon Park, Bohyoung Kim, Nariya Cho, Woo Kyung Moon
SJR Q1Radiology

Background Recent studies suggest that US-guided directional vacuum-assisted removal (DVAR) is a satisfactory alternative to surgery for benign papilloma of the breast and recommend discretionary diagnostic US follow-up without intervention. Purpose To compare the outcomes of benign papilloma without atypia diagnosed with core needle biopsy (CNB) in patients who underwent US-guided DVAR, US follow-up without intervention, or surgery. Materials and Methods This retrospective review included conse

Pathology and Forensic MedicineMedicine
10
Article|48 citations·2017
The Management Strategy of Benign Solitary Intraductal Papilloma on Breast Core Biopsy
Dayoung Ko, Eunyoung Kang, So Yeon Park, Sun Mi Kim, Mijung Jang, Bo La Yun, Sumin Chae, Yerang Jang, Hye Jin Kim, Sung‐Won Kim, Eun-Kyu Kim
SJR Q2Clinical Breast Cancer
Pathology and Forensic MedicineMedicine
11
Article|46 citations·2019
Additive value of diffusion‐weighted MRI in the I‐SPY 2 TRIAL
Wen Li, David C. Newitt, Lisa J. Wilmes, Ella F. Jones, Vignesh A. Arasu, Jessica Gibbs, Bo La Yun, Elizabeth Li, Savannah C. Partridge, John Kornak, Laura J. Esserman, Nola M. Hylton
SJR Q1Journal of Magnetic Resonance ImagingOA

BACKGROUND: The change in apparent diffusion coefficient (ADC) measured from diffusion-weighted imaging (DWI) has been shown to be predictive of pathologic complete response (pCR) for patients with locally invasive breast cancer undergoing neoadjuvant chemotherapy. PURPOSE: To investigate the additive value of tumor ADC in a multicenter clinical trial setting. STUDY TYPE: Retrospective analysis of multicenter prospective data. POPULATION: In all, 415 patients who enrolled in the I-SPY 2 TRIAL fr

Radiology, Nuclear Medicine and ImagingMedicine
12
Article|30 citations·2014
Intratumoral Heterogeneity of Breast Cancer Xenograft Models: Texture Analysis of Diffusion-Weighted MR Imaging
Bo La Yun, Nariya Cho, Mulan Li, Min Hye Jang, So Yeon Park, Ho Chul Kang, Bohyoung Kim, In Chan Song, Woo Kyung Moon
SJR Q1Korean Journal of RadiologyOA

The texture analysis of ADC maps may help to determine the intratumoral spatial heterogeneity of necrosis patterns, amount of cellular proliferation and the vascularity in MCF-7 and MDA-MB-231 xenograft breast cancer models.

Radiology, Nuclear Medicine and ImagingMedicine
13
Article|24 citations·2020
Breast Arterial Calcification is Associated with the Progression of Coronary Atherosclerosis in Asymptomatic Women: A Preliminary Retrospective Cohort Study
Yeonyee E. Yoon, Kyoung Min Kim, Wonjae Lee, Jong Soo Han, Eun Ju Chun, Soyeon Ahn, Sang Il Choi, Bo La Yun, Jung‐Won Suh
SJR Q1Scientific ReportsOA

We evaluated whether breast arterial calcification (BAC) is associated with the progression of coronary atherosclerosis in asymptomatic women. This retrospective observational cohort study analysed asymptomatic women from the BBC registry. In 126 consecutive women (age, 54.5 ± 7.0 years) who underwent BAC evaluation and repeated coronary computed tomography angiography (CCTA) examinations, the coronary arterial calcification score (CACS) and segment stenosis score (SSS) were evaluated to assess

Radiology, Nuclear Medicine and ImagingMedicine
14
Article|23 citations·2018
Comparison of the Diagnostic Performance of Synthetic Versus Acquired High b‐Value (1500 s/mm2) Diffusion‐Weighted MRI in Women With Breast Cancers
Jung Hyun Park, Bo La Yun, Mijung Jang, Hye Shin Ahn, Sun Mi Kim, Soo Hyun Lee, Eunyoung Kang, Eun‐Kyu Kim, So Yeon Park
SJR Q1Journal of Magnetic Resonance Imaging

BACKGROUND: ) diffusion-weighted imaging (DWI) has its strength in lesion detection. However, it is not easily used, due to a lower signal-to-noise ratio, eddy current distortions, and prolonged acquisition times. Synthetic DWI does not have these disadvantages because it is based on indirect acquisition, calculated in a voxel-wise manner. PURPOSE: ) DWI in women with breast cancer. STUDY TYPE: Retrospective. POPULATION: A total of 108 patients (median age 49 years [range 32-77]) with 133 breast

Radiology, Nuclear Medicine and ImagingMedicine
15
Article|17 citations·2011
Radiofrequency Ablation for Treating Liver Metastases from a Non-Colorectal Origin
Bo La Yun, Jeong Min Lee, Ji Hyun Baek, Se Hyung Kim, Jae Young Lee, Joon Koo Han, Byung Ihn Choi
SJR Q1Korean Journal of RadiologyOA

OBJECTIVE: We wanted to assess the safety and efficacy of performing radiofrequency ablation (RFA) in patients with non-colorectal liver metastases. MATERIALS AND METHODS: In this retrospective study, 25 patients with 40 hepatic metastases (M:F = 17:8; mean age, 57 years; tumor size, 0.5-5.0 cm) from a non-colorectal origin (stomach, biliary, breast, pancreas, kidney and skin) were treated with RFA. The RFA procedures were performed using either an internally cooled electrode or a clustered elec

HepatologyMedicine

Research Areas

Radiology, Nuclear Medicine and ImagingPathology and Forensic MedicineCancer ResearchPulmonary and Respiratory MedicineGeneticsArtificial Intelligence

Dive deeper into Bo La Yun's research on Nubint

Open this lab's papers in the app to read with AI, summarize, and cite in your writing.