Chang-hee Lee
Korea University · Medicine
About the Lab
Professor Chang-hee Lee's research lab specializes in abdominal and musculoskeletal radiology, with a strong focus on advanced MRI techniques for non-invasive diagnosis and characterization of liver diseases, including non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). The lab develops multiparametric MRI biomarkers—such as diffusion-weighted imaging, perfusion parameters, and hepatobiliary phase imaging—to improve diagnostic accuracy and predict treatment response. A key research direction involves understanding the role of immune modulation, particularly through TAM receptor tyrosine kinases in macrophage function, linking radiological findings with underlying immunological mechanisms. The lab also investigates anatomical landmarks and morphological features for improved spinal and vascular imaging interpretation.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The aim of our study was to examine the locational distribution of paraspinal structures on MRI and to determine any predictable parameters that may be used for the identification of transitional vertebra (TV). We enrolled 534 patients who underwent MRI of their lumbosacral spine. The locations of the paraspinal structures, such as aortic bifurcation (AB), IVC confluence (IC), right renal artery (RRA), celiac trunk (CT), SMA root (SR), and iliolumbar ligament (ILL), were determined using "cross
Non-alcoholic steatohepatitis (NASH) is a complex disease consisting of various components including steatosis, lobular inflammation, and ballooning degeneration, with or without fibrosis. Therefore, it is difficult to diagnose NASH with only one imaging modality. This study was aimed to evaluate the feasibility of magnetic resonance imaging (MRI) for predicting NASH and to develop a non-invasive multiparametric MR index for the detection of NASH in non-alcoholic fatty liver disease (NAFLD) pati
Both AER derived from contrast enhanced MRI and D* values derived from IVIM-DWI for HCC were significantly higher in LGU than in LPU. These parameters would be helpful for predicting the lipiodol uptake.
HBP improved the imaging characteristics of infiltrative HCC, allowing it to be distinguished from focal CF. Infiltrative HCC showed lower ADC values than focal CF. Lobular configuration, contour bulging, enhancement pattern, associated satellite nodules and portal vein thrombosis were still found to be highly suggestive MR findings for infiltrative HCC.
Macrophage is an important innate immune cell that not only initiates inflammatory responses, but also functions in tissuerepair and anti-inflammatory responses. Regulating macrophage activity is thus critical to maintain immune homeostasis. Tyro3, Axl, and Mer are integral membrane proteins that constitute TAM family of receptor tyrosine kinases (RTKs). Growing evidence indicates that TAM family receptors play an important role in anti-inflammatory responses through modulating the function of m
OBJECTIVE: The aim of this study was to assess whether a short breath-hold technique can improve hepatic arterial phase (HAP) image quality in gadoxetic acid-enhanced magnetic resonance (MR) imaging compared with a conventional long breath-hold technique. MATERIALS AND METHODS: Institutional review board approval and patient consent were obtained for this prospective randomized control study. One hundred nineteen patients undergoing gadoxetic acid-enhanced MR imaging were randomly assigned to gr
Noninvasive evaluation of hepatic tumor response is necessary to improve the survival rate and quality of life of cancer patients. Among radiologic imaging modalities, MRI plays a significant role in the management of patients with hepatic tumor and is crucial for diagnosis, treatment planning and assessment of response or recurrence, because of its high contrast resolution, lack of ionizing radiation and the possibility of performing functional imaging sequences. This review provides an overvie
Since MRS and MRI-PDFF demonstrated a strong correlation with each other and with the two different histopathologic methods, they can be used as an alternative noninvasive reference standard in nonalcoholic fatty liver disease (NAFLD) patients. However, these preliminary results should be interpreted with caution until they are validated in further studies.
Purpose To identify the most reliable imaging features for differentiating hepatocellular carcinoma with paradoxical uptake on the hepatobiliary phase (HCC para ) from focal nodular hyperplasia (FNH)‐like nodules using Gd‐EOB‐DTPA‐enhanced MRI. Materials and Methods This was a retrospective study. Twenty patients with HCC para and 21 patients with FNH‐like nodules were included. The following MRI features were evaluated using 3.0 Tesla unit by two radiologists: signal intensity (SI) on T1‐, T2‐,
Research Areas
Dive deeper into Chang-hee Lee's research on Nubint
Open this lab's papers in the app to read with AI, summarize, and cite in your writing.