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Chang Hyun Lee

Seoul National University · Medicine

About the Lab

Professor Chang Hyun Lee's research lab specializes in biomedical imaging and radiation safety, with a focus on optimizing diagnostic imaging techniques to reduce patient radiation exposure while maintaining image quality. The lab investigates advanced computed tomography (CT) technologies, including automatic exposure control systems and low-dose imaging protocols, to enhance clinical outcomes. Additionally, the lab explores the impact of environmental factors—such as air pollution—on respiratory diseases, particularly chronic obstructive pulmonary disease (COPD), through epidemiological and imaging-based research. The integration of artificial intelligence in medical image interpretation, including computer-aided detection (CAD) and maximum intensity projection (MIP) techniques, further strengthens the lab’s contributions to diagnostic accuracy.

radiation dose optimizationmedical imagingcomputed tomographyenvironmental healthartificial intelligence in radiology

Research Overview

Papers
294
Total Citations
6,372
Papers (5y)
48
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
48total
2022
2023
2024
2025
2026
Citations per year (5y)
330total
20222023202420252026

Selected Papers

15
1
Review|312 citations·2008
Radiation Dose Modulation Techniques in the Multidetector CT Era: From Basics to Practice
Chang Hyun Lee, Jin Mo Goo, Hyun Ju Ye, Sung‐Joon Ye, Chang Min Park, Eun Ju Chun, Jung-Gi Im
SJR Q1Radiographics

Radiation exposure to the patient has become a concern for the radiologist in the multidetector computed tomography (CT) era. With the introduction of faster multidetector CT scanners, various techniques have been developed to reduce the radiation dose to the patient; one method is automatic exposure control (AEC). AEC systems make use of different types of control, including patient-size AEC, z-axis AEC, rotational or angular AEC, or a combination of two or more of these types. AEC systems oper

Radiology, Nuclear Medicine and ImagingMedicine
2
Review|181 citations·2021
Impact of long-term exposure to ambient air pollution on the incidence of chronic obstructive pulmonary disease: A systematic review and meta-analysis
Jimyung Park, Hyung‐Jun Kim, Chang‐Hoon Lee, Chang Hyun Lee, Chang Hyun Lee, Chang Hyun Lee, Hyun Woo Lee
SJR Q1Environmental ResearchOA

Background: It is well known that air pollution causes respiratory morbidity and mortality by inducing airway inflammation. However, whether long-term exposure to air pollution is associated with increased incidence of chronic obstructive pulmonary disease (COPD) is controversial. Methods: We conducted a systematic review and meta-analysis with a random-effects model to calculate the pooled risk estimates of COPD development per 10 μg/m3 increase in individual air pollutants. PubMed, Embase, and

Health, Toxicology and MutagenesisEnvironmental Science
3
Article|117 citations·2018
A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition
Chang Hyun Lee, Marianthi Kiparaki, Jorge Polo Blanco, Virginia Folgado, Zhejun Ji, Amit Kumar, Gerard Rimesso, Nicholas E. Baker
SJR Q1Developmental CellOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
4
Article|86 citations·2004
A novel SONOS structure of SiO/sub 2//SiN/Al/sub 2/O/sub 3/ with TaN metal gate for multi-giga bit flash memories
Chang Hyun Lee, Kyung In Choi, Myoung Kwan Cho, Yun Heub Song, Kyu Charn Park, Kinam Kim

A novel SONOS structure of SiO/sub 2//SiN/Al/sub 2/O/sub 3/ (SANOS) with TaN metal gate is for the first time proposed for the next generation non-volatile memory technology. When TaN metal gate is applied for the SANOS instead of commonly used n+ poly-Si, the unwanted backward Fowler-Nordheim tunneling current of electrons through the top oxide is significantly suppressed owing to its higher work function and better compatibility with high k dielectrics. As a result, the program/erase speed is

Electrical and Electronic EngineeringEngineering
5
Article|80 citations·2008
Radiologic and Pathologic Findings of Nonpalpable Thyroid Carcinomas Detected by Ultrasonography in a Medical Screening Center
Ji Yang Kim, Chang Hyun Lee, Soo Young Kim, Woo Ki Jeon, Jin Hwa Kang, Su Kyung An, Woo Sun Jun
SJR Q2Journal of Ultrasound in Medicine

Ultrasonographic findings suggesting malignancy should be preferentially considered as indicators for FNA, regardless of size, in nonpalpable thyroid nodules. However, extracapsular invasion and lymph node metastasis are closely related to the size of the thyroid nodule.

Endocrinology, Diabetes and MetabolismMedicine
6
Article|43 citations·2009
Efficacy of Computer-Aided Detection System and Thin-Slab Maximum Intensity Projection Technique in the Detection of Pulmonary Nodules in Patients With Resected Metastases
Eun‐Ah Park, Jin Mo Goo, Jeong Won Lee, Chang Hyun Kang, Hyun Ju Lee, Chang Hyun Lee, Chang Min Park, Ho Yun Lee, Jung-Gi Im
SJR Q1Investigative Radiology

In candidates for metastatectomy, reading with the aid of either CAD or MIP significantly improved the detection of malignant nodules compared with using thin-section CT alone.

Pulmonary and Respiratory MedicineMedicine
7
Article|42 citations·2007
The Crazy-paving Sign1
Chang Hyun Lee
SJR Q1Radiology
Pulmonary and Respiratory MedicineMedicine
8
Article|40 citations·2007
CTA Contrast Enhancement of the Aorta and Pulmonary Artery
Chang Hyun Lee, Jin Mo Goo, Kyongtae T. Bae, Hyun Ju Lee, Kwang Gi Kim, Eun Ju Chun, Chang Min Park, Jung-Gi Im
SJR Q1Investigative Radiology

Saline chase prolongs the duration of plateau and delays peak enhancement of the pulmonary artery and aorta. Saline chase injected at half the rate of contrast medium injection allowed more uniform and prolonged plateau contrast enhancement than other protocols.

Radiology, Nuclear Medicine and ImagingMedicine
9
Article|40 citations·2007
Determination of Optimal Timing Window for Pulmonary Artery MDCT Angiography
Chang Hyun Lee, Jin Mo Goo, Hyun Ju Lee, Kwang Gi Kim, Jung-Gi Im, Kyongtae T. Bae
SJR Q1American Journal of Roentgenology

With our study protocol of a 30-second injection and 10-second saline flush, the optimal temporal window to achieve pulmonary artery enhancement greater than 200 H was from 16 seconds to 41 seconds after the start of the injection.

Internal MedicineMedicine
10
Article|38 citations·2016
Whole-Genome Sequencing and iPLEX MassARRAY Genotyping Map an EMS-Induced Mutation Affecting Cell Competition in Drosophila melanogaster
Chang Hyun Lee, Gerard Rimesso, David M. Reynolds, Jinlu Cai, Nicholas E. Baker
SJR Q2G3 Genes Genomes GeneticsOA

Cell competition, the conditional loss of viable genotypes only when surrounded by other cells, is a phenomenon observed in certain genetic mosaic conditions. We conducted a chemical mutagenesis and screen to recover new mutations that affect cell competition between wild-type and RpS3 heterozygous cells. Mutations were identified by whole-genome sequencing, making use of software tools that greatly facilitate the distinction between newly induced mutations and other sources of apparent sequence

Molecular BiologyBiochemistry, Genetics and Molecular Biology
11
Article|31 citations·2008
Semiquantitative Measurement of Murine Bleomycin-Induced Lung Fibrosis in In Vivo and Postmortem Conditions Using Microcomputed Tomography: Correlation With Pathologic Scores???Initial Results
Hyun Ju Lee, Jin Mo Goo, Na Ra Kim, Sunghoon Kim, Doo Hyun Chung, Kyu-Ri Son, Hyo‐Cheol Kim, Chang Hyun Lee, Chang Min Park, Eun Ju Chun, Jung-Gi Im
SJR Q1Investigative Radiology

Micro-CT scores and pathologic scores were found to be well correlated by in vivo and postmortem micro-CT. Although agreements between in vivo and postmortem micro-CT were significant, the confidence levels for fibrosis-related CT findings were significantly higher by postmortem micro-CT.

Pulmonary and Respiratory MedicineMedicine
12
Article|27 citations·2008
Highly scalable NAND flash memory with robust immunity to program disturbance using symmetric inversion-type source and drain structure
Chang Hyun Lee, Jungdal Choi, Young‐Woo Park, Changseok Kang, Byeong-In Choi, Hyunjae Kim, Hyunsil Oh, Won-Seong Lee

The symmetric inversion-type S/D structure has been employed for achieving available program disturbance for scaled NAND flash memory beyond sub-40 nm node. The inversion S/D structure enables the channel doping to be reduced due to non-existence of n-lateral diffusion and it suppresses charge sharing between program-inhibit channels, resulting in superior program disturbance. Moreover, the cells show better current drivability in the technology node less than 50 nm by more successful working of

Computer Networks and CommunicationsComputer Science
13
Article|24 citations·2008
Is the Computer-Aided Detection Scheme for Lung Nodule Also Useful in Detecting Lung Cancer?
Jin Mo Goo, Hyae Young Kim, Jeong Won Lee, Hyun Ju Lee, Chang Hyun Lee, Kyung Won Lee, Tae Jung Kim, Kun Young Lim, Seong Ho Park, Kyongtae T. Bae
SJR Q3Journal of Computer Assisted Tomography

The overall radiologists' performance of detecting lung nodules was improved significantly with the use of CAD, whereas no statistical significance was observed for the detection of lung cancers. The use of CAD, however, contributed to the detection of additional lung cancers for less experienced readers.

Pulmonary and Respiratory MedicineMedicine
14
Article|21 citations·2012
Quantitative analysis of dynamic airway changes after methacholine and salbutamol inhalation on xenon-enhanced chest CT
Sang Joon Park, Chang Hyun Lee, Jin Mo Goo, Jong Hyo Kim, Eun‐Ah Park, Jae‐Woo Jung, Heung‐Woo Park, Sang‐Heon Cho
SJR Q1European Radiology
Atomic and Molecular Physics, and OpticsPhysics and Astronomy
15
Article|18 citations·2022
Pulmonary fibrosis model using micro-CT analyzable human PSC–derived alveolar organoids containing alveolar macrophage-like cells
Seri Choi, Jiwoong Choi, Seongmin Cheon, Jihong Song, Seung-Yeon Kim, Ji-Eun Kim, Dae-Hwan Nam, Gohar Manzar, Su‐Man Kim, Hyung‐Sik Kang, Kee K. Kim, Sang Hoon Jeong
SJR Q1Cell Biology and ToxicologyOA
Pulmonary and Respiratory MedicineMedicine

Research Areas

Pulmonary and Respiratory MedicineRadiology, Nuclear Medicine and ImagingOncologyEpidemiologyPhysiologySurgery

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