Dong-Hoon Han
Korea Advanced Institute of Science and Technology · Medicine
About the Lab
Professor Dong-Hoon Han's research lab specializes in chemical engineering and biomedical applications, with a focus on reactive extraction processes for organic acid recovery—particularly lactic acid—using amine-based extractants like trioctylamine. The lab also investigates cardiac complications from electrical injuries and explores advanced critical care interventions such as extracorporeal membrane oxygenation (ECMO) and novel therapies for ischemia-reperfusion injury in myocardial infarction. Their work bridges chemical process engineering with clinical medicine, emphasizing mechanistic studies and translational applications in wound care and cardiovascular protection. The lab integrates experimental data with modeling to optimize separation processes and improve patient outcomes in critical care settings.
Research Overview
Research Output Trend
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Selected Papers
15Abstract The trioctylamine (TOA)/methylene chloride (MC)/n-hexane system was used as the extraction agent for the extraction of lactic acid. Curves of equilibrium and hydration were obtained at various temperatures and concentrations of TOA. A modified mass action model was proposed to interpret the equilibrium and the hydration curves. The reaction mechanism and the corresponding parameters which best represent the equilibrium data were estimated, and the concentration of water in the organic p
Thermal energy is an essential and useful resource to humans in modern society. However, a consequence of using heat carelessly is burns. Burn injuries have various causes, such as exposure to flame, radiation, electrical, and chemical sources. In this study, we reviewed the history of burn wound care while focusing on the basic principles of burn management. Through this review, we highlight the need for careful monitoring and customization when treating burn victims at each step of wound care,
ABSTRACT ABSTRACT Trioctylamine (TOA) was used as the extraction agent for reactive extraction in various active diluents. Equilibrium and hydration data for various active diluents were obtained in 0.6 M TOA systems. From these data we divided the active diluents used into three classes: active diluents containing chlorine atoms, carbon-bonded oxygen donor active diluents, and phosphorus-bonded oxygen donor active diluents. This classification was based on the characteristic groups of active di
Objectives To date, no research has investigated the association between cardiac complication and electrical injury; hence, we aimed to assess the consequences and relating factors of cardiac complications from electrical injuries in South Korea. Design Retrospective single-centre study. Participants 721 patients who had electrical injury–related admission during 2007–2017. An electronic medical record system was used to extract records of patients admitted for electrical injury treatment. Resul
Background and Objectives: Extracorporeal membrane oxygenation (ECMO) can be helpful in patients with cardiogenic shock associated with myocardial infarction, and its early use can improve the patient survival rate. In this study, we report a mortality rate-difference analysis that examined the time and location of shock occurrence. Materials and Methods: We enrolled patients who underwent ECMO due to cardiogenic shock related to myocardial infarction and assigned them to either a pre- or post-a
Ischemia-reperfusion (IR) injury accelerates myocardial injury sustained during the myocardial ischemic period and thus abrogates the benefit of reperfusion therapy in patients with acute myocardial infarction. We investigated the efficacy of intracoronary ethylenediaminetetraacetic acid (EDTA) administration as an adjunctive treatment to coronary intervention to reduce IR injury in a swine model. We occluded the left anterior descending artery for 1 h. From the time of reperfusion, we infused 5
OBJECTIVE: Activated platelets release serotonin, causing platelet aggregation and vasoconstriction. Serotonin levels were investigated in patients with acute coronary syndrome (ACS) and chronic stable angina (CSA) treated with percutaneous coronary intervention (PCI). METHODS: Consecutive patients undergoing PCI for either ACS or CSA were enrolled between July 2009 and April 2010. Patients were pre-treated with dual antiplatelet agents (aspirin and clopidogrel) before PCI. Serum serotonin level
Partial trisomy 3p results from either unbalanced translocation or de novo duplication. Common clinical features consist of dysmorphic facial features, congenital heart defects, psychomotor and mental retardation, abnormal muscle tone, and hypoplastic genitalia. In this paper, we report a case of partial trisomy 3p with rare clinical manifestations. A full-term, female newborn was transferred to our clinic. She had cleft lip-plate, dysgenesis of the corpus callosum, patent ductus arteriosus, pul
BACKGROUND/AIMS: Despite the U.S. Food and Drug Adminstration approving a magnetic resonance imaging (MRI)-conditional pacemaker system in 2011, many physicians remain reluctant to perform MRI scanning in patients with cardiac implantable electronic devices. Herein, we aimed to evaluate the real-world safety of MRI in these patients. METHODS: This single-center retrospective study examined the interrogation data and outcomes of patients with pacemakers or implantable cardioverter defibrillators
ABSTRACT: Vascular access (VA) failure is an important problem for patients undergoing hemodialysis, and maintaining VA patency is challenging. In this study, we used a nationwide database to investigate the effects of nitrate, as a vasodilator, on VA failure in hemodialysis patients.We investigated the Korean insurance claims data of hemodialysis patients who underwent angioplasty for VA failure between January 2012 and December 2017. The patients were divided into 2 groups: those not receiving
Abstract The Rotarex ® device is used for thrombectomy as well as atherectomy in patients with PAD. It is important to carefully consider the wire position of the Rotarex ® device during the procedure. As possible as the wire should be located in a lesion‐free area.
In this retrospective single-center study, ABS and COM showed no difference in clinical efficacy. Both stents can be effectively used for the endovascular intervention of femoropopliteal artery disease when it is necessary.
Research Areas
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