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Dong-Kyu Jin

Yonsei University · Medicine

About the Lab

Professor Dong-Kyu Jin's research lab specializes in medical genetics and molecular pathology, with a primary focus on lysosomal storage disorders such as mucolipidosis and Hunter syndrome. The lab investigates disease-causing mutations in genes like GNPTA, GNPTAG, and IDS, employing molecular diagnostics, mutation analysis, and functional modeling to understand disease mechanisms. Additionally, the lab explores genetic and cytogenetic aspects of neurodevelopmental and growth disorders, including Xp deletion syndromes, integrating clinical phenotypes with molecular and chromosomal microarray analyses. The research also extends to spinal disorders and interventional techniques like vertebroplasty, particularly in the context of pregnancy and structural spine correction.

lysosomal storage disordersgenetic mutationsMucolipidosisHunter syndromechromosomal microarray

Research Overview

Papers
204
Total Citations
3,326
Papers (5y)
34
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
34total
2022
2023
2024
2025
2026
Citations per year (5y)
121total
20222023202420252026

Selected Papers

15
1
Article|244 citations·2007
Prevalence of osteoporosis in patients requiring spine surgery: incidence and significance of osteoporosis in spine disease
Dong Kyu Chin, Jeong Yoon Park, Yeo-Seung Yoon, Sung Uk Kuh, Byung-Ho Jin, Keun Su Kim, Yong Eun Cho
SJR Q1Osteoporosis InternationalOA
Orthopedics and Sports MedicineMedicine
2
Article|170 citations·2008
Recollapse of previous vertebral compression fracture after percutaneous vertebroplasty
Dong Hwa Heo, Dong Kyu Chin, Yong Soo Yoon, Sung Uk Kuh
SJR Q1Osteoporosis InternationalOA
SurgeryMedicine
3
Article|164 citations·2016
Paraspinal muscle, facet joint, and disc problems: risk factors for adjacent segment degeneration after lumbar fusion
Jong Yeol Kim, Dal Sung Ryu, Ho Kyu Paik, Sang Soak Ahn, Moo Sung Kang, Kyung Hyun Kim, Jeong Yoon Park, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Sung Uk Kuh
SJR Q1The Spine JournalOA
Pathology and Forensic MedicineMedicine
4
Article|101 citations·2005
Contributing factors affecting the prognosis surgical outcome for thoracic OLF
Sung Uk Kuh, Young Soo Kim, Yong Eun Cho, Byung Ho Jin, Keun Su Kim, Young Sul Yoon, Dong Kyu Chin
SJR Q1European Spine JournalOA
SurgeryMedicine
5
Article|74 citations·2013
Unilateral versus bilateral percutaneous pedicle screw fixation in minimally invasive transforaminal lumbar interbody fusion
Un Yong Choi, Jeong Yoon Park, Kyung Hyun Kim, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho
SJR Q1Neurosurgical FOCUSOA

OBJECT: Clinical results for unilateral pedicle screw fixation after lumbar interbody fusion have been reported to be as good as those for bilateral instrumentation. However, no studies have directly compared unilateral and bilateral percutaneous pedicle screw fixation after minimally invasive surgery (MIS) for transforaminal lumbar interbody fusion (TLIF). The purpose of this study was to determine whether unilateral percutaneous pedicle screw fixation is comparable with bilateral percutaneous

Pathology and Forensic MedicineMedicine
6
Article|73 citations·1990
Cerebrovascular disease in Hong Kong Chinese.
Chaoran Huang, Franky Leung Chan, Y L Yu, E. Woo, Dong Kyu Chin
SJR Q1Stroke

Our prospective study of cerebrovascular disease in Hong Kong confirms a previous clinical impression that stroke in the Chinese has a pattern different from that in Caucasians. We studied 540 patients (aged 20-70 years) with stroke. Computed tomography or autopsy was obtained in 86.1% and showed an increase in the proportion with lacunar infarction, striatocapsular infarction, and parenchymal hemorrhage relative to the frequencies in Caucasians. This increase in the incidence of cerebral hemorr

EpidemiologyMedicine
7
Review|72 citations·2008
Clinical Approach and Surgical Strategy for Spinal Diseases in Pregnant Women
In-Ho Han, Sung Uk Kuh, Jae‐Hoon Kim, Dong Kyu Chin, Keun Su Kim, Young-Sul Yoon, Byung-Ho Jin, Yong Eun Cho
SJR Q1SpineOA

In most spinal diseases, including HLD and tumors, prepartum surgical treatment can be safely performed maintaining pregnancy. For patients with progressive neurologic deficit at 34 to 36 weeks gestation or later, spine surgery should be performed following the induction of delivery or a cesarean section, or at the same time.

Public Health, Environmental and Occupational HealthMedicine
8
Article|47 citations·2006
Efficacy of Postural Reduction in Osteoporotic Vertebral Compression Fractures Followed by Percutaneous Vertebroplasty
Dong Kyu Chin, Young Soo Kim, Yong Eun Cho, Jun Jae Shin
SJR Q1NeurosurgeryOA

OBJECTIVE: Vertebroplasty in the symptomatic osteoporotic vertebral fracture has become increasingly popular. However, there have been some limitations in restoring the height of the collapsed vertebrae and in preventing the leaking of cement. In the severely collapsed vertebrae of more than two thirds of their original height, vertebroplasty is regarded as a contraindication. We tried postural reduction using a soft pillow under the compressed level. This study was undertaken to investigate the

SurgeryMedicine
9
Article|33 citations·2002
Predictors of Successful Outcome for Lumbar Chemonucleolysis: Analysis of 3000 Cases during the Past 14 Years
Young Soo Kim, Dong Kyu Chin, Yong Eun Cho, Byung-Ho Jin, Do-Heum Yoon
SJR Q1Neurosurgery

OBJECTIVE: Among numerous minimally invasive procedures for the treatment of herniated lumbar disc disease (HLD), chymopapain chemonucleolysis has the longest history of clinical usage. Long-term studies indicated good clinical results with a low risk for patients. However, much confusion still remains about the indications. This study was conducted to evaluate the predictors of successful outcome for chemonucleolysis and to firmly establish the proper indications for this procedure. METHODS: Th

Pathology and Forensic MedicineMedicine
10
Article|24 citations·2019
Progression of Cervical Ossification of Posterior Longitudinal Ligament After Laminoplasty or Laminectomy With Posterior Fixation
Moo Sung Kang, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Byung Ho Jin, Yong Eun Cho
SJR Q1Clinical Spine Surgery A Spine PublicationOA

STUDY DESIGN: Retrospective case analysis. OBJECTIVE: This study was conducted to investigate the course of ossification of the posterior longitudinal ligament (OPLL) progression after laminoplasty (LP) or laminectomy with posterior fixation (PF). SUMMARY OF BACKGROUND DATA: LP is now recognized as a standard technique for the treatment of cervical multisegment OPLL; however, PF is beneficial for patients with severe stenosis. In recent years, there has been increasing interest in mechanical str

SurgeryMedicine
11
Article|23 citations·2012
What is the importance of “halo” phenomenon around bone cement following vertebral augmentation for osteoporotic compression fracture?
K. H. Kim, Sung Uk Kuh, Jeong Yoon Park, Keun Su Kim, Dong Kyu Chin, Yong Eun Cho
SJR Q1Osteoporosis International
SurgeryMedicine
12
Article|18 citations·2013
Association of VKORC1-1639G>A polymorphism with susceptibility to ossification of the posterior longitudinal ligament of the spine: a Korean study
Dong Kyu Chin, Inbo Han, Alexander E. Ropper, Young‐Joo Jeon, Do‐Hyung Kim, Young-Sung Kim, Youngseok Park, Yang D. Teng, Nam Keun Kim, Sung Uk Kuh
SJR Q1Acta NeurochirurgicaOA
SurgeryMedicine
13
Article|17 citations·2009
Herniated nucleus pulposus in isthmic spondylolisthesis: higher incidence of foraminal and extraforaminal types
Keun Su Kim, Dong Kyu Chin, Jeong Yoon Park
SJR Q1Acta NeurochirurgicaOA
Pathology and Forensic MedicineMedicine
14
Article|15 citations·1986
Neuropsychiatric complications related to use of prazosin in patients with renal failure.
Dong Kyu Chin, Almeida Ho, C Y Tse
SJR Q1BMJOA

That the efferent limb of the "clubbing reflex" may be humoral is suggested by observations of hormonal factors being associated with clubbing.Patients with bronchial carcinoma and hypertrophic pulmonary osteoarthropathy have been reported to have raised concentrations ofgrowth hormone.3Clubbing has also been described in association with a case of thyroid carcinoma and primary hyperparathyroidism.4 Lam et al reported two cases (in brothers) with pachydermatoperiostosis, hypertrophic gastropathy

RheumatologyMedicine
15
Article|10 citations·2024
Re-Evaluating the Long-Term Efficacy of Semi-Rigid Fixation Using a Nitinol Spring Rod in Lumbar Surgery: A Retrospective Study on an Effective Alternative for Reducing Adjacent Segment Disease
Hyun Jun Jang, Bongju Moon, Dong Kyu Chin
SJR Q2Applied SciencesOA

Adjacent segment disease (ASD) is a prevalent complication following lumbar fusion surgery, representing a significant challenge in spinal surgery. This study aimed to assess the long-term outcomes of Nitinol spring rod semi-rigid fixation, a potential alternative to traditional rigid fixation, in reducing the incidence of ASD. This retrospective case study evaluated 89 patients who underwent lumbar or lumbosacral surgeries using a combination of Bioflex® (a Nitinol spring rod dynamic stabilizat

Pathology and Forensic MedicineMedicine

Research Areas

SurgeryPathology and Forensic MedicineRheumatologyNeurologyOrthopedics and Sports MedicineEpidemiology

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