Dong-Kyu Jin
Yonsei University · Medicine
About the Lab
Professor Dong-Kyu Jin's research lab specializes in medical genetics and molecular pathology, with a primary focus on lysosomal storage disorders such as mucolipidosis and Hunter syndrome. The lab investigates disease-causing mutations in genes like GNPTA, GNPTAG, and IDS, employing molecular diagnostics, mutation analysis, and functional modeling to understand disease mechanisms. Additionally, the lab explores genetic and cytogenetic aspects of neurodevelopmental and growth disorders, including Xp deletion syndromes, integrating clinical phenotypes with molecular and chromosomal microarray analyses. The research also extends to spinal disorders and interventional techniques like vertebroplasty, particularly in the context of pregnancy and structural spine correction.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15OBJECT: Clinical results for unilateral pedicle screw fixation after lumbar interbody fusion have been reported to be as good as those for bilateral instrumentation. However, no studies have directly compared unilateral and bilateral percutaneous pedicle screw fixation after minimally invasive surgery (MIS) for transforaminal lumbar interbody fusion (TLIF). The purpose of this study was to determine whether unilateral percutaneous pedicle screw fixation is comparable with bilateral percutaneous
Our prospective study of cerebrovascular disease in Hong Kong confirms a previous clinical impression that stroke in the Chinese has a pattern different from that in Caucasians. We studied 540 patients (aged 20-70 years) with stroke. Computed tomography or autopsy was obtained in 86.1% and showed an increase in the proportion with lacunar infarction, striatocapsular infarction, and parenchymal hemorrhage relative to the frequencies in Caucasians. This increase in the incidence of cerebral hemorr
In most spinal diseases, including HLD and tumors, prepartum surgical treatment can be safely performed maintaining pregnancy. For patients with progressive neurologic deficit at 34 to 36 weeks gestation or later, spine surgery should be performed following the induction of delivery or a cesarean section, or at the same time.
OBJECTIVE: Vertebroplasty in the symptomatic osteoporotic vertebral fracture has become increasingly popular. However, there have been some limitations in restoring the height of the collapsed vertebrae and in preventing the leaking of cement. In the severely collapsed vertebrae of more than two thirds of their original height, vertebroplasty is regarded as a contraindication. We tried postural reduction using a soft pillow under the compressed level. This study was undertaken to investigate the
OBJECTIVE: Among numerous minimally invasive procedures for the treatment of herniated lumbar disc disease (HLD), chymopapain chemonucleolysis has the longest history of clinical usage. Long-term studies indicated good clinical results with a low risk for patients. However, much confusion still remains about the indications. This study was conducted to evaluate the predictors of successful outcome for chemonucleolysis and to firmly establish the proper indications for this procedure. METHODS: Th
STUDY DESIGN: Retrospective case analysis. OBJECTIVE: This study was conducted to investigate the course of ossification of the posterior longitudinal ligament (OPLL) progression after laminoplasty (LP) or laminectomy with posterior fixation (PF). SUMMARY OF BACKGROUND DATA: LP is now recognized as a standard technique for the treatment of cervical multisegment OPLL; however, PF is beneficial for patients with severe stenosis. In recent years, there has been increasing interest in mechanical str
That the efferent limb of the "clubbing reflex" may be humoral is suggested by observations of hormonal factors being associated with clubbing.Patients with bronchial carcinoma and hypertrophic pulmonary osteoarthropathy have been reported to have raised concentrations ofgrowth hormone.3Clubbing has also been described in association with a case of thyroid carcinoma and primary hyperparathyroidism.4 Lam et al reported two cases (in brothers) with pachydermatoperiostosis, hypertrophic gastropathy
Adjacent segment disease (ASD) is a prevalent complication following lumbar fusion surgery, representing a significant challenge in spinal surgery. This study aimed to assess the long-term outcomes of Nitinol spring rod semi-rigid fixation, a potential alternative to traditional rigid fixation, in reducing the incidence of ASD. This retrospective case study evaluated 89 patients who underwent lumbar or lumbosacral surgeries using a combination of Bioflex® (a Nitinol spring rod dynamic stabilizat
Research Areas
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