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Dong Yul Lee

Sungkyunkwan University · Medicine

About the Lab

Professor Dong Yul Lee's research lab focuses on the molecular and physiological mechanisms underlying aging, with a particular emphasis on the roles of nutrient sensing, lipid metabolism, and environmental factors such as temperature and diet in regulating lifespan and healthspan. The lab employs model organisms like *C. elegans* to investigate transcriptional regulators such as SREBP and MDT-15 in maintaining lipid homeostasis and stress resistance. Research also extends to human health interventions, including lifestyle exercises like walking, to improve body composition and metabolic health in middle-aged populations. The lab integrates molecular biology, genetics, and translational physiology to explore how metabolic pathways influence aging and chronic disease prevention.

aginglipid metabolismlifespan regulationnutrient sensingtranslational physiology

Research Overview

Papers
343
Total Citations
3,167
Papers (5y)
95
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
95total
2022
2023
2024
2025
2026
Citations per year (5y)
318total
20222023202420252026

Selected Papers

15
1
Article|298 citations·2005
Validation of the Korean Version of the Oswestry Disability Index
Dong-Yun Kim, Dong-Yeop Lee, Ho-Yeon Lee, Hyunju Lee, Sang-Beom Chang, Sang-Ki Chung, Hyun-Jib Kim
SJR Q1Spine

In Brief Study Design. Validation of a translated, culturally adapted questionnaire. Objectives. To translate and culturally adapt a Korean version of the Oswestry Disability Index (ODI) and to validate its use in Korean patients. Summary of Background Data. The ODI is one of the most widely used and validated instruments for measuring disability in spinal disorders. However, no validated Korean version of the index was available at the time our study was initiated. Methods. The study was carrie

PharmacologyMedicine
2
Article|135 citations·2015
SREBP and MDT-15 protectC. elegansfrom glucose-induced accelerated aging by preventing accumulation of saturated fat
Dong-Yeop Lee, Dae‐Eun Jeong, Heehwa G. Son, Yasuyo Yamaoka, Hyunmin Kim, Keunhee Seo, Abdul Aziz Khan, Tae‐Young Roh, Dae Won Moon, Youngsook Lee, Seung‐Jae Lee
SJR Q1Genes & DevelopmentOA

Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator-15 (MDT-15) prevent the life-shortening effects of a glucose-rich diet by regulating fat-converting processes in Caenorhabditis elegans. Up-regulation of the SREBP/MDT-15 transcription factor complex was necessary and sufficient for alleviating the life-shortening effect of a

AgingBiochemistry, Genetics and Molecular Biology
3
Review|75 citations·2014
Effects of nutritional components on aging
Dong-Yeop Lee, Wooseon Hwang, Murat Artan, Dae‐Eun Jeong, Seung‐Jae Lee
SJR Q1Aging CellOA

Nutrients including carbohydrates, proteins, lipids, vitamins, and minerals regulate various physiological processes and are essential for the survival of organisms. Reduced overall caloric intake delays aging in various organisms. However, the role of each nutritional component in the regulation of lifespan is not well established. In this review, we describe recent studies focused on the regulatory role of each type of nutrient in aging. Moreover, we will discuss how the amount or composition

PhysiologyMedicine
4
Article|74 citations·2019
MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis
Dong-Yeop Lee, Seon Woo A. An, Yoonji Jung, Yasuyo Yamaoka, Youngjae Ryu, Grace Ying Shyen Goh, Arshia Beigi, Jae‐Seong Yang, Gyoo Yeol Jung, K. Dengke, Chang Man Ha, Stefan Taubert
SJR Q1PLoS BiologyOA

Low temperatures delay aging and promote longevity in many organisms. However, the metabolic and homeostatic aspects of low-temperature-induced longevity remain poorly understood. Here, we show that lipid homeostasis regulated by Caenorhabditis elegans Mediator 15 (MDT-15 or MED15), a transcriptional coregulator, is essential for low-temperature-induced longevity and proteostasis. We find that inhibition of mdt-15 prevents animals from living long at low temperatures. We show that MDT-15 up-regu

AgingBiochemistry, Genetics and Molecular Biology
5
Review|37 citations·2016
The role of dietary carbohydrates in organismal aging
Dong-Yeop Lee, Heehwa G. Son, Yoonji Jung, Seung‐Jae Lee
SJR Q1Cellular and Molecular Life SciencesOA
AgingBiochemistry, Genetics and Molecular Biology
6
Article|21 citations·2023
Influence of the Hawthorne effect on spatiotemporal parameters, kinematics, ground reaction force, and the symmetry of the dominant and nondominant lower limbs during gait
Jeong-Woo Jeon, Seon-young Kwon, Yoon-mi Lee, Yoon-mi Lee, Jae-Ho Yu, Jinseop Kim, Seong-Gil Kim, Dong-Yeop Lee, Dong-Yeop Lee
SJR Q1Journal of Biomechanics
PharmacologyMedicine
7
Article|19 citations·2013
The Effect of Walking Exercise on Physical Fitness and Serum Lipids in Obese Middle-aged Women: Pilot Study
Dong-Yeop Lee, Byoung-Do Seo, Sang-Mi Chung
Journal of Physical Therapy ScienceOA

[Purpose] This study was conducted to identify the effects of walking on the body composition, health-related physical fitness, and serum lipids as part of efforts to encourage middle-aged people to participate in walking as a regular and sustainable exercise. [Methods] This study was conducted as a pretest-posttest control group study. The study period was for 12 weeks from January to March 2010. The participants were 43 middle-aged women (age range: 40-55 years) with body fat rates over 30%. S

PhysiologyMedicine
8
Article|17 citations·2018
The effect of therapeutic abdominal drawing-in maneuver using ultrasonography on lateral abdominal muscle thickness and balance
Ji-Yeon Lee, Dong-Yeop Lee
SJR Q2Journal of Back and Musculoskeletal Rehabilitation

Performing the bridging exercise with abdominal drawing-in maneuver is a more effective way to strengthen the abdominal muscles and stabilize the body than bridging exercise only.

PharmacologyMedicine
9
Article|9 citations·2018
Effect of different speeds and ground environment of squat exercises on lower limb muscle activation and balance ability
Ji Yeon Lee, Dong-Yeop Lee
SJR Q3Technology and Health Care

For optimal performance and effect of selected squat exercises, the speed and ground environment should be taken into consideration.

Orthopedics and Sports MedicineMedicine
10
Article|9 citations·2016
Design and Construction of an Automated Irrigation System for Simulating Saltwater Intrusion in a Tidal Freshwater Wetland
Dong-Yeop Lee, Olivia A. De Meo, Robert B. Thomas, Allison L. Tillett, Scott C. Neubauer
SJR Q2Wetlands
EcologyEnvironmental Science
11
Article|8 citations·2023
Adverse events of a third dose of BNT162b2 mRNA COVID-19 vaccine among Korean healthcare workers
Dong-Yeop Lee, Dong Yoon Kang, Eunjung Kim, Se-joo Lee, Ji Hyeon Baek, Jin Soo Lee, Mi Youn Park, Jae Hyoung Im
SJR Q3MedicineOA

Due to the urgency of controlling the coronavirus disease 2019 pandemic, coronavirus disease 2019 messenger ribonucleic acid (mRNA) vaccines have been expeditiously approved and introduced in several countries without sufficient evaluation for adverse events. We analyzed adverse events among Korean healthcare workers who received all 3 doses of the BNT162b2 mRNA vaccine. This survey was conducted among hospital workers of Inha University Hospital who had received the BNT162b2 mRNA vaccine for th

Infectious DiseasesMedicine
12
Article|7 citations·2010
The Effects of Virtual Reality-based Exercise on Energy Expenditure during Gait in Chronic Stroke Patients
Dong-Yeop Lee, Won-Seob Shin
Journal of the Korea Academia-Industrial cooperation SocietyOA

본 연구는 가상현실을 이용한 재활운동을 적용하여 뇌졸중 환자의 보행시 에너지 소모의 효율성에 효과가 있는가를 알아보고자 하였다. 뇌졸중으로 6개월 이상 장애를 가진 32명이 연구에 참여하였고 가상현실군 16명과 대조군 16명으로 나누었다. 가상현실군은 가상현실을 이용한 게임장치를 이용하여 1시간씩 주 3회를 6주간 실시하였다. 대조군은 운동의 적용없이 평상시 생활을 유지하도록 하였다. 운동 전과 후에 심박동수와 보행속도를 측정하여 에너지소모지수를 산출하여 효과를 비교하였다. 통계처리 방법으로 운동 전후 차이를 검증하기 위하여 대응표본 t 검정을 실시하였고 그룹간 차이 검증을 위하여 독립표본 t 검정을 실시하였다. 모든 통계적 유의수준은 0.05로 하였다. 연구결과 대조군과 비교하여 가상현실군에서 보행시 에너지소모지수가 유의하게 감소하였다(p<.05). 결론적으로 가상현실을 이용한 재활운동이 뇌졸중 환자의 보행시 에너지 소모에 있어 효과적이며 보행능력의 향상에 효과적인 방법임을 확인하

RehabilitationMedicine
13
Article|5 citations·2016
The Influence Factors on Health-Related Quality of Life of Middle-Aged Working Women
Dong-Yeop Lee, Eun Hee Shin
Indian Journal of Science and TechnologyOA

Background/Objectives: The objective of this research is to grasp the middle-aged working women’s physical condition, climacteric symptom, job-family complications, social support and health related quality of life, and its influence factor. Methods/Statistical Analysis: This research is the descriptive interrelation to grasp the factor that affects the health related quality of life of middle-aged working women, and targeted to 141 middle-aged career women living in C province and D province. T

General Health ProfessionsHealth Professions
14
Article|5 citations·2014
The effect of transcutaneous electrical nerve stimulation on postural sway on fatigued dorsi-plantar flexor
Jae-Ho Yu, Soyeon Lee, HyongJo Kim, Dong-Kwon Seo, JiHeon Hong, Dong-Yeop Lee
SJR Q3Technology and Health Care

The application of transcutaneous electrical nerve stimulation (TENS) enhances muscle weakness and static balance by muscle fatigue. It was said that TENS affects decrease of the postural sway. On the other hand, the applications of TENS to separate dorsi-plantar flexor and the comparison with and without visual input have not been studied. Thus, the aim of this study was to compare the effects of TENS on fatigued dorsi-plantar flexor with and without visual input. 13 healthy adult males and 12

Biomedical EngineeringEngineering
15
Article|5 citations·2006
Related Factors of the Motivation for Rehabilitation in Stroke Patients
Dong-Yeop Lee, Moo‐Sik Lee, Baeg-Ju Na, Keon-Yeop Kim, Dongjin Lee, Dae-Kyoung Kim
Physical Therapy Korea

The purpose of this study was to investigate the relations between financial stress, depression, and conjugal affection and the motivation for rehabilitation. One hundred eighty-six stroke patients were included in the study and a survey with 65 questions was used. The survey includes questions to evaluate personal factors, characteristics related with physical therapy, characteristics related with disease, depression, conjugal affection, and motivation for rehabilitation. Education, employment,

Public Health, Environmental and Occupational HealthMedicine

Research Areas

PharmacologyAgingOrthopedics and Sports MedicineBiomedical EngineeringSurgeryPublic Health, Environmental and Occupational Health

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