Du-Hyun Jung
Seoul National University · Medicine
About the Lab
Professor Du-Hyun Jung's research lab focuses on the intricate interplay between innate and adaptive immunity in lung diseases and cancer. The lab investigates immune checkpoint regulation, particularly PD-1/PD-L1 and TIM family molecules, in the tumor microenvironment of lung cancer. It also explores the roles of pattern recognition receptors like TLR2 and transcription factors such as IRF5 and Pellino-1 in macrophage polarization and fibrotic lung diseases. Additionally, the lab examines the functions of regulatory T cells and innate lymphoid cells in immune homeostasis and pathological inflammation.
Research Overview
Research Output Trend
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Selected Papers
15Programmed cell death (PD)-1/PD-1 ligand-1 (PD-L1)-targeted therapy has emerged as a promising therapeutic strategy for lung cancer. However, whether EML4-ALK regulates PD-L1 expression in lung cancer remains unknown. A total of 532 pulmonary adenocarcinomas (pADCs), including 58 ALK-translocated tumors, were immunohistochemically evaluated for PD-L1 and PD-1. H23 (EGFRWild-typeEML4-ALK−PD-L1Low) and H2228 (EGFRWild-typeEML4-ALK+PD-L1High) cells were transfected with EML4-ALK or ALK short interf
Abstract Purpose: The plasticity of innate lymphoid cells (ILCs) has been reported in vitro and in the microenvironment of the intestine. However, whether ILC plasticity contributes to regulation of the tumor microenvironment remains unknown. In this study, we explored plasticity of ILCs in human lung cancer. Experimental Design: We analyzed immune subsets and cytokine expression in lung cancers freshly obtained from 80 patients and explored conversion of ILC1 into ILC3 in coculture with lung ca
Research Areas
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