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Du Hyun Ro

Seoul National University · Medicine

About the Lab

Professor Du Hyun Ro's research lab specializes in orthopedic biomechanics and clinical prediction modeling, focusing on improving outcomes in joint arthroplasty and osteoarthritis. The lab integrates machine learning and big data analytics to develop predictive models for postoperative complications such as blood transfusion, acute kidney injury, and implant revision. Key research directions include gait analysis to understand joint mechanics in knee osteoarthritis, sex-based biomechanical differences in aging populations, and the clinical impact of medications like bisphosphonates on implant longevity. The lab emphasizes translational research, translating biomechanical and clinical data into web-based decision support tools for surgeons and patients.

total knee arthroplastymachine learninggait analysispredictive modelingosteoporosis and bone metabolism

Research Overview

Papers
151
Total Citations
2,300
Papers (5y)
88
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
88total
2022
2023
2024
2025
2026
Citations per year (5y)
736total
20222023202420252026

Selected Papers

15
1
Article|89 citations·2019
Transfusion after total knee arthroplasty can be predicted using the machine learning algorithm
Changwung Jo, Sunho Ko, Woo Cheol Shin, Hyuk‐Soo Han, Myung Chul Lee, Taehoon Ko, Du Hyun Ro
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

PURPOSE: A blood transfusion after total knee arthroplasty (TKA) is associated with an increase in complication and infection rates. However, no studies have been conducted to predict transfusion after TKA using a machine learning algorithm. The purpose of this study was to identify informative preoperative variables to create a machine learning model, and to provide a web-based transfusion risk-assessment system for clinical use. METHODS: This study retrospectively reviewed 1686 patients who un

BiochemistryMedicine
2
Article|82 citations·2019
Effects of Knee Osteoarthritis on Hip and Ankle Gait Mechanics
Du Hyun Ro, Joonhee Lee, Jangyun Lee, Jae‐Young Park, Hyuk‐Soo Han, Myung Chul Lee
SJR Q3Advances in OrthopedicsOA

INTRODUCTION: Knee osteoarthritis (OA) can affect the hip and ankle joints, as these three joints operate as a kinetic/kinematic chain while walking. PURPOSE: This study was performed to compare (1) hip and ankle joint gait mechanics between knee OA and control groups and (2) to investigate the effects of knee gait mechanics on the ipsilateral hip and ankle joint. METHODS: The study group included 89 patients with end-stage knee OA and 42 age- and sex-matched controls without knee pain or OA. Ki

RheumatologyMedicine
3
Article|72 citations·2020
A web‐based machine‐learning algorithm predicting postoperative acute kidney injury after total knee arthroplasty
Sunho Ko, Changwung Jo, Chong Bum Chang, Yong Seuk Lee, Young‐Wan Moon, Jae woo Youm, Hyuk‐Soo Han, Myung Chul Lee, Hajeong Lee, Du Hyun Ro
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

PURPOSE: Acute kidney injury (AKI) is a deleterious complication after total knee arthroplasty (TKA). The purposes of this study were to identify preoperative risk factors and develop a web-based prediction model for postoperative AKI, and assess how AKI affected the progression to ESRD. METHOD: The study included 5757 patients treated in three tertiary teaching hospitals. The model was developed using data on 5302 patients from two hospitals and externally validated in 455 patients from the thi

NephrologyMedicine
4
Article|63 citations·2018
The use of bisphosphonates after joint arthroplasty is associated with lower implant revision rate
Du Hyun Ro, Heejin Jin, Jae Young Park, Myung Chul Lee, Sungho Won, Hyuk‐Soo Han
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

PURPOSE: This study hypothesized that the use of bisphosphonates (BPs) after total joint arthroplasty (TJA) is associated with a lower implant revision rate. This study aimed (1) to investigate the association between BP use and the revision rate of TJA and (2) to determine the relationship between the medication period and the revision rate of TJA. METHODS: National Health Insurance Service data on surgeries, medications, diagnoses, and screenings of 50 million Koreans were reviewed. People who

OncologyMedicine
5
Article|58 citations·2020
A machine learning-based diagnostic model associated with knee osteoarthritis severity
Soon Bin Kwon, Yunseo Ku, Hyuk-Soo Han, Myung Chul Lee, Hee Chan Kim, Du Hyun Ro
SJR Q1Scientific ReportsOA

Knee osteoarthritis (KOA) is characterized by pain and decreased gait function. We aimed to find KOA-related gait features based on patient reported outcome measures (PROMs) and develop regression models using machine learning algorithms to estimate KOA severity. The study included 375 volunteers with variable KOA grades. The severity of KOA was determined using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). WOMAC scores were used to classify disease severity into th

RheumatologyMedicine
6
Article|50 citations·2016
Sex differences in knee joint loading: Cross-sectional study in geriatric population
Du Hyun Ro, Dong Yeon Lee, Giho Moon, Sahnghoon Lee, Sang Gyo Seo, Seong Hwan Kim, In Woong Park, Myung Chul Lee
SJR Q1Journal of Orthopaedic Research®OA

This study investigated sex differences in knee biomechanics and investigated determinants for difference in a geriatric population. Age-matched healthy volunteers (42 males and 42 females, average age 65 years) without knee OA were included in the study. Subjects underwent physical examination on their knee and standing full-limb radiography for anthropometric measurements. Linear, kinetic, and kinematic parameters were compared using a three-dimensional, 12-camera motion capture system. Gait p

RheumatologyMedicine
7
Article|39 citations·2012
Photoplethysmography and Continuous-Wave Doppler Ultrasound as a Complementary Test to Ankle–Brachial Index in Detection of Stenotic Peripheral Arterial Disease
Du Hyun Ro, Hyuk Ju Moon, Ji Hyeung Kim, Kyoung Min Lee, Sung Ju Kim, Dong Yeon Lee
SJR Q2Angiology

PURPOSE: We evaluated the sensitivity and specificity of ankle-brachial index (ABI), photoplethysmography (PPG), and continuous-wave Doppler ultrasound (CWD) in the detection of anatomically stenotic peripheral arterial disease (PAD). METHODS: Ninety-seven patients (194 legs) patients who had coincidentally undergone computed tomography angiography (CTA), ABI, PPG, and CWD for the evaluation of PAD were retrospectively reviewed. Sensitivity and specificity were measured. RESULTS: Among 194 legs,

SurgeryMedicine
8
Article|36 citations·2022
Deep learning‐based landmark recognition and angle measurement of full‐leg plain radiographs can be adopted to assess lower extremity alignment
Changwung Jo, Doohyun Hwang, Sunho Ko, Myung Ho Yang, Myung Chul Lee, Hyuk‐Soo Han, Du Hyun Ro
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

PURPOSE: Evaluating lower extremity alignment using full-leg plain radiographs is an essential step in diagnosis and treatment of patients with knee osteoarthritis. The study objective was to present a deep learning-based anatomical landmark recognition and angle measurement model, using full-leg radiographs, and validate its performance. METHODS: A total of 11,212 full-leg plain radiographs were used to create the model. To train the data, 15 anatomical landmarks were marked by two orthopaedic

SurgeryMedicine
9
Article|36 citations·2017
Slow gait speed after bilateral total knee arthroplasty is associated with suboptimal improvement of knee biomechanics
Du Hyun Ro, Hyuk‐Soo Han, Dong Yeon Lee, Seong Hwan Kim, Yoon-Ho Kwak, Myung Chul Lee
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

Retrospective cohort study, Level III.

SurgeryMedicine
10
Article|26 citations·2022
A machine-learning model to predict postoperative delirium following knee arthroplasty using electronic health records
Jong Wook Jung, Sunghyun Hwang, Sunho Ko, Changwung Jo, Hye Youn Park, Hyuk‐Soo Han, Myung Chul Lee, Jee Eun Park, Du Hyun Ro
SJR Q1BMC PsychiatryOA

BACKGROUND: Postoperative delirium is a challenging complication due to its adverse outcome such as long hospital stay. The aims of this study were: 1) to identify preoperative risk factors of postoperative delirium following knee arthroplasty, and 2) to develop a machine-learning prediction model. METHOD: A total of 3,980 patients from two hospitals were included in this study. The model was developed and trained with 1,931 patients from one hospital and externally validated with 2,049 patients

Critical Care and Intensive Care MedicineMedicine
11
Article|23 citations·2022
Mechanism of action of genicular artery embolization in a rabbit model of knee osteoarthritis
Du Hyun Ro, Myoung‐jin Jang, Jaemoon Koh, Won Seok Choi, Hyo‐Cheol Kim, Hyuk‐Soo Han, Jin Woo Choi
SJR Q1European Radiology
RheumatologyMedicine
12
Article|21 citations·2024
Enhanced deep learning model enables accurate alignment measurement across diverse institutional imaging protocols
Sung Eun Kim, Jun Woo Nam, Joong Il Kim, Jong-Keun Kim, Du Hyun Ro
SJR Q1Knee Surgery and Related ResearchOA

BACKGROUND: Achieving consistent accuracy in radiographic measurements across different equipment and protocols is challenging. This study evaluates an advanced deep learning (DL) model, building upon a precursor, for its proficiency in generating uniform and precise alignment measurements in full-leg radiographs irrespective of institutional imaging differences. METHODS: The enhanced DL model was trained on over 10,000 radiographs. Utilizing a segmented approach, it separately identified and ev

SurgeryMedicine
13
Article|21 citations·2022
High‐resolution knee plain radiography image synthesis using style generative adversarial network adaptive discriminator augmentation
Gun Ahn, Byung Sun Choi, Sunho Ko, Changwung Jo, Hyuk‐Soo Han, Myung Chul Lee, Du Hyun Ro
SJR Q1Journal of Orthopaedic Research®

In this retrospective study, 10,000 anteroposterior (AP) radiography of the knee from a single institution was used to create medical data set that are more balanced and cheaper to create. Two types of convolutional networks were used, deep convolutional GAN (DCGAN) and Style GAN Adaptive Discriminator Augmentation (StyleGAN2-ADA). To verify the quality of generated images from StyleGAN2-ADA compared to real ones, the Visual Turing test was conducted by two computer vision experts, two orthopedi

Artificial IntelligenceComputer Science
14
Article|20 citations·2019
Quantitative evaluation of gait features after total knee arthroplasty: Comparison with age and sex-matched controls
Du Hyun Ro, Tae Hoon Kang, Do Hwan Han, Dong Yeon Lee, Hyuk‐Soo Han, Myung Chul Lee
SJR Q1Gait & Posture
SurgeryMedicine
15
Article|19 citations·2022
Low muscle mass is an independent risk factor for postoperative blood transfusion in total knee arthroplasty: a retrospective, propensity score-matched cohort study
Doohyun Hwang, Hyuk‐Soo Han, Myung Chul Lee, Du Hyun Ro
SJR Q1BMC GeriatricsOA

Abstract Background Sarcopenia, an age-related loss of skeletal muscle mass and function, is correlated with adverse outcomes after some surgeries. This study examined the characteristics of sarcopenic patients undergoing primary total knee arthroplasty (TKA), and identified low muscle mass as an independent risk factor for postoperative TKA complications. Methods A retrospective cohort study examined 452 patients who underwent TKA. The skeletal muscle index (SMI) was obtained via bioelectrical

PhysiologyMedicine

Research Areas

SurgeryRheumatologyHealth InformaticsBiochemistryCritical Care and Intensive Care MedicineBiomedical Engineering

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