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Geun-soo Kim

Yonsei University · Medicine

About the Lab

Professor Geun-soo Kim's research lab specializes in spinal degeneration and spinal surgery, with a focus on intervertebral disc biology, disc degeneration models, and spinal implant technologies. The lab investigates the biological mechanisms underlying disc degeneration, including the effects of nicotine on disc cell metabolism and extracellular matrix regulation, as well as the clinical outcomes of spinal instrumentation and arthroplasty. Research also extends to surgical strategies for spinal fusion and the management of spinal disorders during pregnancy, emphasizing both experimental models and clinical applications. The lab integrates molecular biology, surgical techniques, and long-term clinical follow-up to advance spinal health and surgical outcomes.

intervertebral discspinal degenerationspinal surgerybone morphogenetic proteinheterotopic ossification

Research Overview

Papers
222
Total Citations
4,493
Papers (5y)
29
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
29total
2022
2023
2024
2025
2026
Citations per year (5y)
169total
20222023202420252026

Selected Papers

15
1
Article|131 citations·2017
Comparison of Outcomes of Anterior, Posterior, and Transforaminal Lumbar Interbody Fusion Surgery at a Single Lumbar Level with Degenerative Spinal Disease
Nam Lee, Yu Seun Kim, Seong Yi, Yoon Ha, Dong Ah Shin, Do Heum Yoon, Keun Su Kim
SJR Q2World NeurosurgeryOA
Pathology and Forensic MedicineMedicine
2
Article|129 citations·2005
Disc Degeneration in the Rabbit: A Biochemical and Radiological Comparison Between Four Disc Injury Models
Keun Su Kim, S. Tim Yoon, Jun Li, Jin Soo Park, William Hutton
SJR Q1Spine

In the first experiment, the 21-gauge 3-puncture and the 18-gauge 1-puncture models produced the most consistent disc degeneration in the rabbit lumbar spine. When these 2 models were again studied in the second experiment, the 21-gauge 3-puncture technique was superior in producing disc degeneration over a shorter period of time.

Pathology and Forensic MedicineMedicine
3
Review|72 citations·2008
Clinical Approach and Surgical Strategy for Spinal Diseases in Pregnant Women
In-Ho Han, Sung Uk Kuh, Jae‐Hoon Kim, Dong Kyu Chin, Keun Su Kim, Young-Sul Yoon, Byung-Ho Jin, Yong Eun Cho
SJR Q1SpineOA

In most spinal diseases, including HLD and tumors, prepartum surgical treatment can be safely performed maintaining pregnancy. For patients with progressive neurologic deficit at 34 to 36 weeks gestation or later, spine surgery should be performed following the induction of delivery or a cesarean section, or at the same time.

Public Health, Environmental and Occupational HealthMedicine
4
Article|66 citations·2019
Modified global alignment and proportion scoring with body mass index and bone mineral density (GAPB) for improving predictions of mechanical complications after adult spinal deformity surgery
Sung Hyun Noh, Yoon Ha, Ibrahim Obeid, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Keun Su Kim, Yong Eun Cho, Hye Sun Lee, Kyung Hyun Kim, Kyung Hyun Kim
SJR Q1The Spine JournalOA
SurgeryMedicine
5
Article|55 citations·2012
What are the associative factors of adjacent segment degeneration after anterior cervical spine surgery? Comparative study between anterior cervical fusion and arthroplasty with 5-year follow-up MRI and CT
Jeong Yoon Park, Kyung Hyun Kim, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Keun Su Kim, Yong Eun Cho
SJR Q1European Spine JournalOA
SurgeryMedicine
6
Article|49 citations·2003
Inhibition of proteoglycan and type II collagen synthesis of disc nucleus cells by nicotine
Keun Su Kim, S. Tim Yoon, Jin Soo Park, Jun Li, Moon Soo Park, William Hutton
SJR Q1Journal of Neurosurgery SpineOA

OBJECT: Systemic nicotine has been hypothesized to cause degeneration of the intervertebral disc which in turn decreases vascular supply to the disc through a cholinergic receptor-mediated process. Another possible mechanism may be through direct regulatory effects on disc cells. In this study, the authors tested the hypothesis that nicotine adversely affects nucleus pulposus cells by directly inhibiting proteoglycan synthesis and gene expression of type II collagen (Phase I study). They also as

Pathology and Forensic MedicineMedicine
7
Article|36 citations·2013
Do Postoperative Biomechanical Changes Induce Heterotopic Ossification After Cervical Arthroplasty?
Keun Su Kim, Dong Hwa Heo
SJR Q1Clinical Spine Surgery A Spine PublicationOA

STUDY DESIGN: Prospective clinical study. OBJECTIVE: To evaluate the factors that would predispose a patient to heterotopic ossification (HO) formation after cervical arthroplasty. SUMMARY OF BACKGROUND DATA: HO after arthroplasty is one of the complications of cervical total disk replacement (TDR). However, the predisposing factors and pathophysiology of HO have not been precisely described. MATERIALS AND METHODS: We prospectively enrolled and followed up 23 patients, who received single-level

SurgeryMedicine
8
Article|36 citations·2005
Radiological Changes in the Bone Fusion Site After Posterior Lumbar Interbody Fusion Using Carbon Cages Impacted With Laminar Bone Chips: Follow-Up Study Over More Than 4 Years
Keun Su Kim, Tai Ki Yang, Jung Chung Lee
SJR Q1Spine

All the intervertebral bone fusion after PLIF occurred inside the cages and in the posterior intervertebral space. We suggest the complete removal of discmaterial and deep insertion of the cages to create sufficient posterior intervertebral space for bone growth. PLIF using cages impacted with laminar bone chips is a useful method when considering the time required for surgery and the morbidity of the autograft donor sites.

Pathology and Forensic MedicineMedicine
9
Article|31 citations·2014
The Fate of Heterotopic Ossification Associated With Cervical Artificial Disc Replacement
Seong Yi, Jae-Keun Oh, Gwi-Hyun Choi, Tae Yup Kim, Hyun Chul Shin, Yu Seun Kim, Keun Su Kim, Do Heum Yoon
SJR Q1SpineOA

3.

SurgeryMedicine
10
Article|27 citations·2017
Management of Esophageal and Pharyngeal Perforation as Complications of Anterior Cervical Spine Surgery
Moo Sung Kang, Kyung Hyun Kim, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Byung Ho Jin, Keun Su Kim, Keun Su Kim, Yong Eun Cho
SJR Q2World NeurosurgeryOA
SurgeryMedicine
11
Article|26 citations·1999
Coulomb distortion effects for(e,e′p)reactions at high electron energies
Keun Su Kim, L. E. Wright
SJR Q1Physical Review COA

We report a significant improvement of an approximate method of including electron Coulomb distortion in electron-induced reactions at momentum transfers greater than the inverse of the size of the target nucleus. In particular, we have found a new parametrization for the elastic electron scattering phase shifts that works well at all electron energies greater than 300 MeV. As an illustration, we apply the improved approximation to the ${(e,e}^{\ensuremath{'}}p)$ reaction from medium and heavy n

Nuclear and High Energy PhysicsPhysics and Astronomy
12
Article|24 citations·2019
Progression of Cervical Ossification of Posterior Longitudinal Ligament After Laminoplasty or Laminectomy With Posterior Fixation
Moo Sung Kang, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Byung Ho Jin, Yong Eun Cho
SJR Q1Clinical Spine Surgery A Spine PublicationOA

STUDY DESIGN: Retrospective case analysis. OBJECTIVE: This study was conducted to investigate the course of ossification of the posterior longitudinal ligament (OPLL) progression after laminoplasty (LP) or laminectomy with posterior fixation (PF). SUMMARY OF BACKGROUND DATA: LP is now recognized as a standard technique for the treatment of cervical multisegment OPLL; however, PF is beneficial for patients with severe stenosis. In recent years, there has been increasing interest in mechanical str

SurgeryMedicine
13
Article|21 citations·2010
The Effect of Training Type on Oxidative DNA Damage and Antioxidant Capacity during Three-Dimensional Space Exercise
Keun Su Kim, Il Young Paik, Jin Hee Woo, Byung Yong Kang
SJR Q1Medical Principles and PracticeOA

OBJECTIVE: Orbotron training is a popular training method for fighter pilots because it replicates a high-acceleration environment with excessive G-force. The purpose of this study was to investigate the effects of 9 weeks of orbotron training on oxidative DNA damage and antioxidant capacity in humans during 3-dimensional space exercise. SUBJECTS AND METHODS: The subjects comprised 15 senior cadets from the Korea Air Force Academy who had no record of medical disorders and who participated in a

RehabilitationMedicine
14
Article|19 citations·2020
Association of complete uncinate process removal on 2-year assessment of radiologic outcomes: subsidence and sagittal balance in patients receiving one-level anterior cervical discectomy and fusion
Sung Hyun Noh, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Kyung Hyun Kim, Kyung Hyun Kim, Kyung Hyun Kim
SJR Q2BMC Musculoskeletal DisordersOA

BACKGROUND: Many patients with cervical radiculopathy experience stenosis of the neural foramens due to cumulative osteophyte or uncovertebral joint hypertrophy. For cervical foraminal stenosis, complete uncinate process resection (UPR) is often conducted concurrently with anterior discectomy and fusion (ACDF). The aim of this study was to assess the clinical and radiological outcomes of ACDF with complete UPR versus ACDF without UPR. METHODS: In total, 105 patients who performed one-level ACDF

SurgeryMedicine
15
Article|17 citations·2009
Herniated nucleus pulposus in isthmic spondylolisthesis: higher incidence of foraminal and extraforaminal types
Keun Su Kim, Dong Kyu Chin, Jeong Yoon Park
SJR Q1Acta NeurochirurgicaOA
Pathology and Forensic MedicineMedicine

Research Areas

SurgeryPathology and Forensic MedicineOrganic ChemistryNeurologyBiomedical EngineeringOrthopedics and Sports Medicine

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