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Gwankyu Park

Yonsei University · Medicine

About the Lab

Professor Gwankyu Park's research lab specializes in orthopedic biomechanics and clinical outcomes following total knee arthroplasty (TKA), with a strong focus on functional recovery, implant positioning, and patient-reported outcomes in Asian populations. The lab investigates the impact of anatomical factors—such as femoral bowing and knee flexion—on surgical outcomes, while also exploring the role of systemic conditions like metabolic syndrome in knee osteoarthritis. Additionally, the lab examines natural biomolecules, such as xanthorrhizol, for their anti-inflammatory and anti-tumorigenic potential in skin disease models. These interdisciplinary efforts aim to improve surgical precision, patient satisfaction, and long-term joint health.

total knee arthroplastyknee osteoarthritisimplant positioningfunctional outcomesmetabolic syndrome

Research Overview

Papers
183
Total Citations
3,179
Papers (5y)
52
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
52total
2022
2023
2024
2025
2026
Citations per year (5y)
429total
20222023202420252026

Selected Papers

15
1
Article|104 citations·2007
Correlation of maximum flexion with clinical outcome after total knee replacement in Asian patients
Kwan Kyu Park, Chong Bum Chang, Yeon Gwi Kang, Sang Cheol Seong, Tae Kyoung Kim
Journal of Bone and Joint Surgery - British VolumeOA

This study aimed to determine the correlation between the amount of maximum flexion and the clinical outcome in 207 Koreans (333 knees) undergoing total knee replacement. The association of maximum flexion with clinical outcome was evaluated one year postoperatively using three scoring systems; the American Knee Society score, Western Ontario McMaster Universities Osteoarthritis index and the Short Form-36. The mean maximum flexion decreased post-operatively at 12 months from 140.1 degrees (60 d

SurgeryMedicine
2
Article|101 citations·2007
Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor- B
Won‐Yoon Chung, Jin‐hong Park, M. J. Kim, Hyun Ok Kim, Jae‐Kwan Hwang, Sang Kook Lee, Kwan Kyu Park
SJR Q1CarcinogenesisOA

Xanthorrhizol is an active component isolated from Curcuma xanthorrhiza Roxb. (Zingiberaceae) that is traditionally used in Indonesia for medicinal purposes. In the present study, we found that the topical application of xanthorrhizol before 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment significantly inhibits TPA-induced mouse ear edema and TPA-induced tumor promotion in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated ICR mouse skin. The topical application of xanthorrhizol following the

Molecular MedicineBiochemistry, Genetics and Molecular Biology
3
Article|78 citations·2013
Correlation between metabolic syndrome and knee osteoarthritis: data from the Korean National Health and Nutrition Examination Survey (KNHANES)
Chang Dong Han, Ik Hwan Yang, Woo-Suk Lee, Yoo Jung Park, Kwan Kyu Park
SJR Q1BMC Public HealthOA

BACKGROUND: This study was designed to investigate the correlations of knee osteoarthritis (OA) with metabolic syndrome (MetS) and MetS parameters in Korean subjects. METHODS: This study included data from 270 subjects with knee OA and 1964 control subjects with a mean age of 54.56 (SD 11.53) years taken from the Korean National Health and Nutritional Examination Survey (KNHANES) 2008. Multivariate logistic regression analysis was conducted to examine possible associations for knee OA with MetS

RheumatologyMedicine
4
Article|75 citations·2008
Normative Temporal Values of CRP and ESR in Unilateral and Staged Bilateral TKA
Kwan Kyu Park, Tae Kyun Kim, Chong Bum Chang, Su Won Yoon, Kyoung Un Park
SJR Q1Clinical Orthopaedics and Related ResearchOA

UNLABELLED: C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) play helpful roles in determining the presence of infection after TKA. To provide baseline values, we documented normative temporal values of CRP and ESR in unilateral and staged bilateral TKAs for osteoarthritis. Levels of CRP and ESR were evaluated before surgery and on the first, second, fifth, seventh, fourteenth, forty-second, and ninetieth postoperative days in 320 uncomplicated primary TKAs. C-reactive protein a

Cardiology and Cardiovascular MedicineMedicine
5
Article|48 citations·2007
Functional Disabilities and Issues of Concern in Female Asian Patients Before TKA
Kwan Kyu Park, Kwang Sook Shin, Chong Bum Chang, Sung Ju Kim, Tae Kyun Kim
SJR Q1Clinical Orthopaedics and Related ResearchOA

There is much enthusiasm in the current field of TKA to allow high-flexion activities that might be important for Asian patients. We investigated functional disabilities and their perceived importance before surgery in 97 Korean female patients undergoing TKA for advanced osteoarthritis. The most important issues relating to functional disability were difficulty in squatting, leg deformity, difficulty in kneeling, unequal leg length, and limping. The most important issues relating to perceived i

SurgeryMedicine
6
Article|40 citations·2015
Femur bowing could be a risk factor for implant flexion in conventional total knee arthroplasty and notching in navigated total knee arthroplasty
Jae Han Ko, Chang Dong Han, Kyoo Ho Shin, Levis Nguku, Ick Hwan Yang, Woo-Suk Lee, Kwang Il Kim, Kwan Kyu Park
SJR Q1Knee Surgery Sports Traumatology ArthroscopyOA

PURPOSE: This study aimed to investigate the relationship between preoperative femoral axes and femoral implant position and to determine how femoral sagittal axes, including femoral anterior bowing, influence the femoral component position in total knee arthroplasty (TKA). METHODS: The relationship between femoral axes (femoral anterior bowing, mechanical axis and the anterior cortical line, intramedullary axis) and implant position was compared in 50 conventional and 50 navigated TKAs. Outlier

SurgeryMedicine
7
Article|38 citations·2015
Three-dimensional in vivo difference between native acetabular version and acetabular component version influences iliopsoas impingement after total hip arthroplasty
Kwan Kyu Park, Tsung‐Yuan Tsai, Dimitris Dimitriou, Young‐Min Kwon
SJR Q1International OrthopaedicsOA
SurgeryMedicine
8
Article|35 citations·2019
Robot-assisted unicompartmental knee arthroplasty can reduce radiologic outliers compared to conventional techniques
Kwan Kyu Park, Chang Dong Han, Ick-Hwan Yang, Woo-Suk Lee, Joo Hyung Han, Hyuck Min Kwon
SJR Q1PLoS ONEOA

In this study, robot-assisted UKA had many advantages over conventional UKA, such as its ability to achieve precise implant insertion and reduce radiologic outliers. Although the clinical outcomes of robot-assisted UKA over a short-term follow-up period were not significantly different compared to those of conventional UKA, longer follow-up period is needed to determine whether the improved radiologic accuracy of the components in robotic-assisted UKA will lead to better clinical outcomes and im

SurgeryMedicine
9
Article|32 citations·2009
Association between Bone Mineral Density and Metabolic Syndrome in Postmenopausal Korean Women
Kwan Kyu Park, Sung‐Jae Kim, Eun Su Moon
SJR Q2Gynecologic and Obstetric InvestigationOA

BACKGROUND/AIMS: We investigated the relationship between bone mineral density (BMD) of the femur neck or lumbar spine and metabolic syndrome or its parameters in postmenopausal Korean women. METHODS: This study included 399 postmenopausal women, for whom the BMD of their L2s-L4s and femur necks were examined in association with metabolic syndrome. RESULTS: Subjects with metabolic syndrome had a higher BMD of the femur neck than those without metabolic syndrome when adjusted for age (0.85 +/- 0.

Orthopedics and Sports MedicineMedicine
10
Article|31 citations·2018
Effect of femoral component position on biomechanical outcomes of unicompartmental knee arthroplasty
Kyoung‐Tak Kang, Juhyun Son, Yong‐Gon Koh, Oh‐Ryong Kwon, Sae Kwang Kwon, Yong Jun Lee, Kwan Kyu Park
SJR Q2The KneeOA
SurgeryMedicine
11
Article|27 citations·2015
Utility of Preoperative Femoral Neck Geometry in Predicting Femoral Stem Anteversion
Kwan Kyu Park, Tsung‐Yuan Tsai, Dimitris Dimitriou, Young‐Min Kwon
SJR Q1The Journal of ArthroplastyOA
SurgeryMedicine
12
Article|26 citations·2018
Flexed femoral component improves kinematics and biomechanical effect in posterior stabilized total knee arthroplasty
Kyoung‐Tak Kang, Yong‐Gon Koh, Juhyun Son, Oh‐Ryong Kwon, Kwan Kyu Park
SJR Q1Knee Surgery Sports Traumatology Arthroscopy

This study found that the femoral component sagittal position is an important factor in knee joint mechanics. In this study, the flexion of femoral component showed a stable reconstruction of the knee extensors' mechanism. Surgeons may consider neutral-to-mild flexed femoral component position, without concerns of anterior notching of the femoral cortex.

SurgeryMedicine
13
Article|26 citations·2012
Relationship between distal screws and femoral arteries in closed hip nailing on computed tomography angiography
Chang Dong Han, Young Han Lee, Kyu Hyun Yang, Ick Hwan Yang, Woo-Suk Lee, Yoo Jung Park, Jin‐Suck Suh, Kwan Kyu Park
SJR Q1Archives of Orthopaedic and Trauma SurgeryOA
Pulmonary and Respiratory MedicineMedicine
14
Article|25 citations·2016
Do zip‐type skin‐closing devices show better wound status compared to conventional staple devices in total knee arthroplasty?
Jae Han Ko, Ick Hwan Yang, Min Seok Ko, Eshnazarov Kamolhuja, Kwan Kyu Park
SJR Q1International Wound JournalOA

This study compared the pain score, cosmetic outcome and wound complication rate between zip-type skin-closing device and conventional staple device. Forty-five subjects with zip-type skin-closing device (the zip group) and 45 subjects with the conventional staple device (the staple group) after total knee arthroplasty were compared. Visual analogue scale score was significantly higher on postoperative (PO) 1, 3, 14 day (D) in the staple group compared to the zip group (P < 0·05). The Vancouver

SurgeryMedicine
15
Article|22 citations·2015
Is Electrocautery of Patella Useful in Patella Non-Resurfacing Total Knee Arthroplasty?: A Prospective Randomized Controlled Study
Sae Kwang Kwon, Levis Nguku, Chang Dong Han, Yong‐Gon Koh, Dong Wook Kim, Kwan Kyu Park
SJR Q1The Journal of ArthroplastyOA
SurgeryMedicine

Research Areas

SurgeryOrthopedics and Sports MedicinePharmacologyRheumatologyMolecular BiologyBiomedical Engineering

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