Hae-Sun Soh

Background: Dangguijagyag-san, also known as Dangguishaoyao-san in Chinese and Toki-shakuyakui-san in Japanese, has been frequently used to treat symptoms associated with dysmenorrhea. The purpose of this trial is to evaluate the efficacy and safety of the herbal medicine, Dangguijagyag-san, relative to those of active control, Gamisoyo-san, and a placebo control for primary dysmenorrhea. Methods: This protocol details a randomized, double-blind, parallel-group, multi-center, investigator-initia

BACKGROUNDS To find early liver cancer, the ministry of health and welfare has conducted surveillance targeting high-risk patients. In 2017, the incidence rate of liver cancer in surveillance was 0.9%, suggesting that a broad patient group was included in surveillance. In this study, to reduce surveillance patients, a prediction model with zero-falsenegative was developed using a machine learning. METHODS To develop the model, we used 2016 Health Insurance Review & Assessment Service-National Pa

Objectives This study aimed to provide a basis for applying Korean medical treatment for childhood anorexia in clinical practice by examining Korean medical etiology, pattern differentiation, and treatment, and focusing on research articles on Chinese medicine. Methods Articles on Chinese medicine related to childhood anorexia published before November 4, 2021, in the China National Knowledge Infrastructure (CNKI), were analyzed. The etiology, pattern differentiation, and Chinese medical treatme

Objectives: The purpose of this study is to find out the factors associated with the probability of using the Western medicine only (WMO), Oriental medicine only (OMO), and both in patients with musculoskeletal disorder in ambulatory care settings. Methods: We used the Korea Health panel data in 2009 to analyze the expenditure of using WMO, OMO, and both. Factors associated with using WMO, OMO, and both were examined by applying multinomial logit model. Results: We identified 3,163 patients aged

Opioids are essential for pain management in patients with serious diseases, but dependence, misuse, and addiction have emerged as serious public health problems. This study investigates opioid regulation, clinical guidelines, and prevention/education programs in the United States, United Kingdom, and Australia, three advanced healthcare nations, to identify strategies applicable to South Korea. All three countries have strict laws regulating opioid use, clinical guidelines targeting healthcare

Objectives This study aimed to determine appropriate treatment and information regarding the current use of Korean medicine treatment via an analysis of the medical records of chronic cough patients. Methods Patients aged 0-18 years who visited Korean pediatrics of Kyung Hee University Korean Medicine Hospital for chronic cough from March 1, 2020 to July 31, 2022, were analyzed to investigate the sociodemographic characteristics, clinical characteristics, and prescribed treatment. Results Thirty

Objectives This study aims to provide directions for future Korean pediatric medicine treatment and researches by analyzing the characteristics of diseases of Korean pediatric outpatients before and after the COVID-19 epidemic. Methods We analyzed the medical records of 10,868 new patients aged 0-18 who visited the Korean pediatrics at Kyung Hee university hospital from January 1, 2019 to June 30, 2021. All patients were divided into 2 groups; patients who visited from January 1, 2019 to Decembe

This study aimed to assess the disease burden in Korean patients with X-linked hypophosphatemia (XLH) by combining quantitative and qualitative data. A cross-sectional study was conducted using patient-reported outcome measures, including EuroQol 5 Dimension (EQ-5D), 36-item Short Form (SF-36), and the Work Productivity and Activity Impairment questionnaire (WPAI). Open-ended interviews were also held to explore personal and social dimensions of living with XLH. The study included twelve partici

The objective of this study was to assess opioid injections prescription rate in Korea. This study utilized the National Health Insurance Service-National Sample Cohort data. The general population consisted of non-cancer outpatients with at least one injection prescription, and the opioid population consisted of non-cancer outpatients with at least one opioid injection prescription from 2008 to 2015. We calculated the total injection rate by dividing the number of injection prescriptions by the

BACKGROUND Many antipsychotic drugs have been used to treat schizophrenia, and many treatment patterns have been observed. Most schizophrenia treatment pattern studies were done by analyzing survey data or several hospitals’ electronic health records. This study aimed to analyze early treatment pathways of newly diagnosed schizophrenia patients. METHOD Using 2012-2017 Health Insurance Review & Assessment Service-National Patients Sample (HIRA-NPS) which was standardized to the Common Data Mode

Objectives This study aimed to evaluate the correlation between pediatric weakness scale scores and growth indices. Furthermore, we intended to calculate the cut-off values for diagnosing Kidney Weak Children through growth indices. Methods A total of 193 patients, aged 6 - 12 years, underwent both the pediatric weakness scale and bone age assessment, and the correlations between the pediatric weakness scale and growth indices were analyzed. Moreover, the cut-off values for diagnosing Kidney Wea

면역항암제의 도입은 기존 치료법의 한계를 극복하며 비소세포폐암 치료의 새로운 패러다임을 제시하였다. 본 연구는 실제 임상 환경에서 면역항암제 도입 전후 국내 진행성 비소세포폐암 환자의 사망률 변화를 평가하고, 면역항암제 도입 후 진단된 환자군의 주요 예후 요인을 규명하고자 수행되었다. 국가 암 등록, 국가검진, 국민건강보험 청구 및 사망 정보를 환자 단위로 결합한 데이터베이스 K-CURE 암 공공 라이브러리를 활용하여, 2015년부터 2019년까지 진행성 NSCLC로 진단된 환자 76,379명을 대상으로 후향적 코호트 분석을 수행하였다. 환자는 면역항암제의 건강보험 등재 시점을 기준으로 도입 전(pre-IO)과 도입 후(post-IO)의 두 군으로 구분되었다. 1년 사망률은 도입 전 56.1%에서 도입 후 51.6%로 유의하게 감소하였으며(p < 0.0001), Cox 회귀분석 결과 전체 사망위험이 11.3% 감소한 것으로 나타났다(Adjusted HR 0.887, 95% CI 0.

Although randomized controlled trials (RCTs) comparing potassium competitive acid blockers (PCABs) andproton-pump inhibitors (PPIs) have been previously conducted, systematic reviews are lacking. In this systematic reviewand meta-analysis, we searched the CENTRAL, EMBASE, MEDLINE, KMBASE, and KoreaMed databases for relevantRCTs up to October 3, 2020. We assessed the Helicobacter pylori eradication rate of PCAB-based first-line triple therapyand compared it with that of PPI-based therapy. In all

Chronic hepatitis B, primarily caused by the Hepatitis B virus, is prevalent in Korea and significantly contributes to liver cancer. Tenofovir disoproxil fumarate (TDF), a key treatment for hepatitis B, is preferred for its efficacy and low resistance. Recently, potential positive side effects, such as weight loss and lipid-lowering, have been contentious, especially since weight gain and high lipid levels are known to influence liver cancer. This study aimed to assess the association between TD

Objective The purpose of this study is to evaluate whether herbal bath shortens the duration of pediatric fever. Methods Databases, such as Medline, EMBASE, Cochrane library, OASIS, KISS, KMBASE, CNKI, Wanfang Med Online were used to search randomized controlled trials. Those trials that included children younger than 18-year-old were evaluated for the clinical efficacy of herbal bath in fever by analyzing ‘body temperature (BT) drop start time’ and ‘time to return to normal BT’. Results 12 stud