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Ho Kyu Lee

Yonsei University · Medicine

About the Lab

Professor Ho Kyu Lee's research lab focuses on cardiovascular and metabolic health, with a strong emphasis on epidemiological and clinical studies related to dyslipidemia, hypertension, diabetes, and non-alcoholic fatty liver disease (NAFLD). The lab investigates the prevalence, management, and risk factors of these conditions in the South Korean population using large-scale national health datasets such as KNHANES and NHI-Big Data. A key research direction involves understanding the interplay between metabolic syndrome components, insulin resistance, and organ-specific complications like diastolic dysfunction and liver fibrosis. The lab also explores community-based interventions to improve preventive health behaviors, particularly in underserved populations such as immigrant women.

dyslipidemiainsulin resistancehypertensionNAFLDepidemiology

Research Overview

Papers
14
Total Citations
264
Papers (5y)
12
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
12total
2013
2019
2020
2021
2023
Citations per year (5y)
148total
20132019202020212023

Selected Papers

14
1
Article|113 citations·2008
Tailored lay health worker intervention improves breast cancer screening outcomes in non-adherent Korean-American women
Hae‐Ra Han, H. Lee, Miji Kim, K. B. Kim
SJR Q1Health Education ResearchOA

Despite rapidly increasing incidence rates of breast cancer, recent immigrants such as Korean-American (KA) women report disproportionately lower utilization of screening tests compared with other ethnic groups. Early screening of breast cancer for this population may be greatly facilitated by indigenous lay health workers (LHWs). We conducted an intervention trial with a 6-month follow-up. Trained LHWs recruited 100 KA women 40 years of age or older who had not had a mammogram during the past 2

OncologyMedicine
2
Article|43 citations·2021
Korea hypertension fact sheet 2020: analysis of nationwide population-based data
김현창, So Mi Jemma Cho, 이호규, Lee Hyeok-Hee, Baek Jongmin, Heo Ji Eun, the Korean Society of Hypertension
https://clinicalhypertension.biomedcentral.com/articles/10.1186/s40885-021-00166-2

The Korean Society of Hypertension has published the Korea Hypertension Fact Sheet 2020 to provide an overview of the magnitude and management status of hypertension and their recent trends.The Fact Sheets were based on the analyses of Korean adults aged 20 years or older of the 2007–2018 Korea National Health and Nutrition Examination Survey (KNHANES) and the 2002–2018 National Health Insurance Big Data (NHI-BD).Currently, the population average of systolic/diastolic blood pressure was 118/76 m

3
Article|31 citations·2021
Dyslipidemia Fact Sheets in Korea 2020: an Analysis of Nationwide Population-based Data
조소미, 이호규, 이혁희, 백종민, 허지은, 주형준, 홍순준, 김현창, Korean Society of Lipidology and Atherosclerosis
https://doi.org/10.12997/jla.2021.10.2.202

Objective: The Korean Society of Lipid and Atherosclerosis (KSoLA) has published the Dyslipidemia Fact Sheets in Korea 2020 to provide an overview of magnitude and management status of dyslipidemia and their recent trends therein. Methods: The Fact Sheets were based on the analyses of Korean adults aged 20 years or older of the 2007–2018 Korea National Health and Nutrition Examination Survey (KNHANES) and the 2002–2018 National Health Insurance Big Data (NHI-BD). Results: Between 2007 and 2018,

4
Article|27 citations·2020
Association between Non-Alcoholic Steatohepatitis and Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Mellitus
이호규, 김규리, 최영주, 허병욱, 이병완, 강은석, 차봉수, 이은직, 이용호, 허갑범
Diabetes and Metabolism Journal

Background: Impaired diastolic heart function has been observed in persons with non-alcoholic fatty liver disease (NAFLD) and/or with type 2 diabetes mellitus (T2DM). However, it is unclear whether NAFLD fibrotic progression, i.e., non-alcoholic steatohepatitis, poses an independent risk for diastolic dysfunction in T2DM. We investigated the association between liver fibrosis and left ventricular (LV) diastolic dysfunction in T2DM. Methods: We analyzed 606 patients with T2DM, aged ≥50 years, who

5
Article|16 citations·2023
Dyslipidemia Fact Sheet in Korea, 2022
Eun-Sun Jin, Jee-Seon Shim, Sung Eun Kim, 배재현, 강신애, 원종철, Shin Min-Jeong, 진흥용, Jenny Moon, 이호규, 김현창, 정인경
https://doi.org/10.12997/jla.2023.12.3.237

Objective: This study aimed to investigate the prevalence and status of dyslipidemia management among South Korean adults, as performed by the Korean Society of Lipid and Atherosclerosis under the name Dyslipidemia Fact Sheet 2022. Methods: We analyzed the lipid profiles, age-standardized and crude prevalence, management status of hypercholesterolemia and dyslipidemia, and health behaviors among Korean adults aged ≥20 years, using the Korea National Health and Nutrition Examination Survey data b

6
Article|10 citations·2020
Association between the Thigh Muscle and Insulin Resistance According to Body Mass Index in Middle- Aged Korean Adults
허지은, 심지선, 이호규, 김현창
Diabetes and Metabolism Journal

Background: We examined the associations between thigh muscle area (TMA) and insulin resistance (IR) according to body mass index (BMI) in middle-aged Korean general population. Methods: TMA was measured using quantitative computed tomography and corrected by body weight (TMA/Wt) in 1,263 men, 788 premenopausal women, and 1,476 postmenopausal women all aged 30 to 64 years. The tertiles of TMA/Wt were calculated separately for men and for premenopausal and postmenopausal women. Homeostatic model

7
Article|9 citations·2020
Association of Snoring with Prediabetes and Type 2 Diabetes Mellitus: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort
조소미, 이호규, 심지선, 김현창
Diabetes and Metabolism Journal

Background: Evidence suggests that habitual snoring is an independent risk factor for poor glycemic health. We examined the associations between snoring with prediabetes and diabetes in Korean population. Methods: Self-reported snoring characteristics were collected from 3,948 middle-aged adults without prior cardiovascular diseases. Multivariable linear regression assessed the association of snoring intensity, frequency, disruptiveness, and disrupted breathing with fasting glucose and glycosyla

8
Article|5 citations·2020
Sex-, Age-, and Metabolic Disorder-Dependent Distributions of Selected Inflammatory Biomarkers among Community-Dwelling Adults
조소미, 이호규, 심지선, 김현창
Diabetes and Metabolism Journal

Background: Inflammatory cytokines are increasingly utilized to detect high-risk individuals for cardiometabolic diseases. However, with large population and assay methodological heterogeneity, no clear reference currently exists. Methods: Among participants of the Cardiovascular and Metabolic Diseases Etiology Research Center cohort, of communitydwelling adults aged 30 to 64 without overt cardiovascular diseases, we presented distributions of tumor necrosis factor (TNF)-α and -β, interleukin (I

10
Article|3 citations·2021
Korea Heart Disease Fact Sheet 2020: Analysis of Nationwide Data
Hyeok-Hee Lee, So Mi Jemma Cho, 이호규, Jongmin Baek, Jang-Ho Bae, Wook-Jin Chung, 김현창
https://doi.org/10.4070/kcj.2021.0097

Background and Objectives: Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. To provide an overview of the temporal trends in the burden of CVD, the Korean Society of Cardiology has published the Korea Heart Disease Fact Sheet in 2020. Methods: We analyzed anonymized data of the Causes of Death Statistics, National Health Insurance Claims Database, and Korea National Health and Nutrition Examination Survey to assess mortality, hospitalizations, and risk factors

11
Article|2 citations·2019
Improving colorectal, oral, breast, and cervical cancer screening rates using an inreach approach
H. Lee, Lee-Kiat Ban, AilunHeather Tseng, Hung-Chun Hsing
Journal of Cancer Research and PracticeOA

The Taiwanese national cancer screening program was established in 1985 by providing Pap smear tests for women. At the same time, trial-based screening for colorectal, oral, and breast cancer screening was initiated. In 1999, outreach services for cancer screening were started and gradually scaled up to the national level. Our hospital is located in Hsinchu, Taiwan. Like many hospitals in Taiwan, we provide cancer screening services to the community. Our baseline screening rate was 96.6% in 2016

OncologyMedicine
13
Article|1 citations·2019
Differences in prevalence of hypertension subtypes according to the 2018 Korean Society of Hypertension and 2017 American College of Cardiology/American Heart Association guidelines: The Korean National Health and Nutrition Examination Survey, 2007–2017 (KNHANES IV-VII)
조소미, 이호규, 김현창
https://clinicalhypertension.biomedcentral.com/articles/10.1186/s40885-019-0129-5

Background: The significance of high systolic and diastolic blood pressure remains controversial. We assessed the differences in prevalence of hypertension and its subtypes according to the different hypertension diagnostic criteria embodied by the 2017 American College of Cardiology/American Heart Association (2017 ACC/AHA) and 2018 Korean Society of Hypertension (2018 KSH) guidelines. Methods: We used the 2007–2017 Korea National Health and Nutrition Examination Survey (KNHANES) data to calcul

14
Article|0 citations·2013
Food, Health & Choices: Development and Implementation a Classroom Wellness Intervention “Positively Healthful Classrooms”
L. Mull, Pamela Koch, E. Abrams, Isobel R. Contento, H. Lee
SJR Q2Journal of Nutrition Education and Behavior
Public Health, Environmental and Occupational HealthMedicine

Research Areas

OncologyPublic Health, Environmental and Occupational Health

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