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Hui-Jae Bang

Yonsei University · Medicine

About the Lab

Professor Hui-Jae Bang's research lab focuses on the tumor microenvironment and systemic inflammatory responses in gastrointestinal cancers, particularly colorectal and gastric cancers. The lab investigates immune-related and inflammatory biomarkers in tumor tissues and their associations with clinicopathological features and patient outcomes. Key research directions include the prognostic significance of microsatellite instability in gastric cancer, the role of pretreatment inflammatory markers in predicting survival and complications, and the identification of novel biomarkers such as APRIL, BAFF, and LAG-3 in colorectal cancer. The lab also explores clinical applications of these markers in surgical decision-making and postoperative risk stratification.

tumor microenvironmentinflammatory biomarkerscolorectal cancergastric cancerprognostic markers

Research Overview

Papers
15
Total Citations
247
Papers (5y)
8
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
8total
2019
2020
2021
2022
2023
Citations per year (5y)
99total
20192020202120222023

Selected Papers

15
1
Article|125 citations·2015
The benefit of microsatellite instability is attenuated by chemotherapy in stage II and stage III gastric cancer: Results from a large cohort with subgroup analyses
Soo Young Kim, Yoon Young Choi, Ji Yeong An, Hyun Beak Shin, Ara Jo, Hyeji Choi, Sang Hyuk Seo, Hui-Jae Bang, Jae‐Ho Cheong, Woo Jin Hyung, Sung Hoon Noh
SJR Q1International Journal of CancerOA

We previously reported that the prognosis of microsatellite instability high (MSI-H) gastric cancer is similar to that of MSI-low/microsatellite stable (MSI-L/MSS) gastric cancer. The reason for this seemed to be related to the effects of chemotherapy. To verify this hypothesis, we expanded the study population and reanalyzed the prognosis of MSI-H gastric cancer. Data from 1,276 patients with Stage II and III gastric cancer who underwent gastrectomy with curative intent between January 2005 and

Pathology and Forensic MedicineMedicine
2
Review|50 citations·2022
Pretreatment inflammatory markers predicting treatment outcomes in colorectal cancer
Sang‐Hyun An, Hongjin Shim, Kwangmin Kim, Bora Kim, Hui‐Jae Bang, Hyejin Do, Hyang-Rae Lee, Young Wan Kim
SJR Q2Annals of ColoproctologyOA

We aimed to review whether pretreatment inflammatory markers reflect the short- and long-term outcomes of patients with colon cancer, rectal cancer, colon and rectal cancers, and metastatic colorectal cancer (CRC). We found that pretreatment complete blood count and blood chemistry tests reflect short-term and long-term oncological outcomes in patients with CRC. Specifically, in patients with colon cancer, hypoalbuminemia was associated with worse postoperative morbidity, mortality, and inferior

OncologyMedicine
3
Article|23 citations·2015
Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: a case control study
Masatoshi Nakagawa, Yoon Young Choi, Ji Yeong An, Hyunsoo Chung, Sang Hyuk Seo, Hyun Beak Shin, Hui-Jae Bang, Shuangxi Li, Hyoung‐Il Kim, Jae‐Ho Cheong, Woo Jin Hyung, Sung Hoon Noh
SJR Q2BMC CancerOA

Surgeons need to be aware of limitations in preoperative predictions of the presence of lymph node metastasis for clinical stage early gastric cancer.

Pulmonary and Respiratory MedicineMedicine
4
Article|16 citations·2020
Delta neutrophil index for predicting mortality in trauma patients who underwent emergent abdominal surgery: A case controlled study
Hui-Jae Bang, Kwangmin Kim, Hongjin Shim, Seongyup Kim, Pil Young Jung, Young Un Choi, Keum Seok Bae, Ik Yong Kim, Ji Young Jang
SJR Q1PLoS ONEOA

Postoperative DNI may be a useful biomarker to predict mortality in trauma patients who underwent emergent abdominal surgery.

Cardiology and Cardiovascular MedicineMedicine
5
Article|14 citations·2023
Expression of Immune-Related and Inflammatory Markers and Their Prognostic Impact in Colorectal Cancer Patients
Sang‐Hyun An, Soo‐Ki Kim, Hye Youn Kwon, Cheol-Su Kim, Hui‐Jae Bang, Hyejin Do, BoRa Kim, Kwangmin Kim, Young Wan Kim
SJR Q1International Journal of Molecular SciencesOA

The tumor microenvironment of colorectal cancer (CRC) is heterogenous; thus, it is likely that multiple immune-related and inflammatory markers are simultaneously expressed in the tumor. The aim of this study was to identify immune-related and inflammatory markers expressed in freshly frozen CRC tissues and to investigate whether they are related to the clinicopathological features and prognosis of CRC. Seventy patients with CRC who underwent curative surgical resection between December 2014 and

OncologyMedicine
6
Article|7 citations·2019
Early experience of a regional trauma center in Gangwon province: First step toward organizing a regional trauma system
Kwangmin Kim, Hongjin Shim, Pil Young Jung, Seongyup Kim, Hui‐Jae Bang, Hye Youn Kwon, Young Un Choi, Keum Seok Bae, Ji Young Jang
SJR Q3Hong Kong Journal of Emergency MedicineOA

Background: The Korean Ministry of Health and Welfare decided to establish a trauma medical service system to reduce preventable deaths. OO hospital in Gangwon Province was selected as a regional trauma center and was inaugurated in 2015. Objectives: This study examines the impact of this center, comparing mortality and other variables before and after inaugurating the center. Methods: Severely injured patients (injury severity score > 15) presenting to OO hospital between January 2014 and De

Emergency MedicineMedicine
7
Preprint|7 citations·2023
Expression of Immune-Related and Inflammatory Markers and Their Prognostic Impact in Colorectal Cancer Patients
Sang‐Hyun An, Soo‐Ki Kim, Hye Youn Kwon, Cheol-Su Kim, Hui‐Jae Bang, Hyejin Do, BoRa Kim, Kwangmin Kim, Young Wan Kim
Preprints.orgOA

The tumor microenvironment of colorectal cancer (CRC) is heterogenous; thus, it is likely that multiple immune-related and inflammatory markers are simultaneously expressed in the tumor. The aim of this study was to identify immune-related and inflammatory markers expressed in freshly frozen CRC tissues and to investigate whether they are related to the clinicopathological features and prognosis of CRC. Seventy patients with CRC who underwent curative surgical resection between December 2014 and

ImmunologyImmunology and Microbiology
8
Article|2 citations·2020
Can bone marrow‐derived mesenchymal stem cells change liver volume?: A case report
Kwangmin Kim, In Sik Shin, Hui‐Jae Bang, Sang‐Hyun An, Gaesung Ha, Hyun Soo Kim, Keum Seok Bae
SJR Q3JGH OpenOA

Several studies have described the effectiveness of mesenchymal stem cell (MSC) transplantation in patients with liver cirrhosis (LC). However, in the majority, biochemical tests, clinical features, and pathologic results were used rather than radiologic tests to compare treatment outcomes. A 57-year-old male visited a stem cell clinic with a diagnosis of LC attributed to hepatitis B virus. This patient took tenofovir and diuretics at the initial presentation and was administered bone marrow-der

GeneticsMedicine
9
Article|2 citations·2022
Concurrent upregulation of immune checkpoint molecule genes in colorectal cancer
Hui‐Jae Bang, Joon Hyung Sohn, Soo‐Ki Kim, Cheol-Su Kim, Mee-Yon Cho, BoRa Kim, Sang‐Hyun An, Kwangmin Kim, Young Wan Kim
SJR Q2Molecular & Cellular Toxicology
OncologyMedicine
10
Article|1 citations·2021
Finding new indicators for operation and angiographic embolization in blunt renal injury patients: a single-center experience over 13 years
Gaesung Ha, Sung Woo Jang, In Sik Shin, Hui‐Jae Bang, Sang‐Hyun An, Keum Seok Bae, Ji Young Jang, Young Wan Kim, Kwangmin Kim
SJR Q2Annals of Surgical Treatment and ResearchOA

When a patient with traumatic kidney injury due to blunt trauma visits an emergency room, even when vital signs are stable, Gerota's fascia should be checked by computed tomography prior to deciding on surgical treatment, and angiographic embolization should be considered if perinephric hematoma rim distance exceeds 2.97 cm.

SurgeryMedicine
11
Article|0 citations·2011
갑상선 결절을 형성하는 하시모토 갑상선염의 초음파 소견에 대한 분석
방휘재, 김광민, 박준범, 배금석, 강성준

Purpose: There are relatively few results from studies on nodular Hashimoto’s thyroiditis. In addition, some Hashimoto’s thyroiditis patients present with irregular symptoms, making the distinction from malignant thyroid nodule difficult. Therefore, we performed analyses on ultrasonographic findings of nodular Hashimoto’s thyroiditis. Methods: A retrospective follow-up study was performed on 76 patients (88 nodules) diagnosed with Hashimoto’s thyroiditis after undergoing fine needle aspiration b

12
Article|0 citations·2015
Understanding the Challenges in Predicting Lymph Node Metastasis of Clinical Stage Early Gastric Cancer
Masatoshi Nakagawa, Yoon Young Choi, Ji Yeong An, Hyun Beak Shin, Hui‐Jae Bang, Shuangxi Li, Hyunsoo Chung, Hyung Il Kim, Jae‐Ho Cheong, Woo Jin Hyung, Sung Hoon Noh
대한임상종양학회 학술대회지
Pulmonary and Respiratory MedicineMedicine
13
Article|0 citations·2015
Preoperative Adverse Events Induced by Chemo or Chemoradiotherapy Are Not Related to Postoperative Complications in Gastric Cancer
Hui‐Jae Bang, Yoon Young Choi, Ji Yeong An, Hyung Il Kim, Jae‐Ho Cheong, Woo Jin Hyung, Sung Hoon Noh
대한임상종양학회 학술대회지
Pulmonary and Respiratory MedicineMedicine
14
Article|0 citations·2016
When Eastern Surgeons Meet Western Patients: A Pilot Study of Gastrectomy with Lymphadenectomy in Caucasian Patients at a Single Korean Institute
Masatoshi Nakagawa, Yoon Young Choi, Ji Yeong An, Sang Hyuk Seo, Hyun Beak Shin, Hui-Jae Bang, Shuangxi Li, Hyoung‐Il Kim, Jae‐Ho Cheong, Woo Jin Hyung, Sung Hoon Noh
SJR Q2Yonsei Medical JournalOA

East Asian surgeons generally report lower morbidity and mortality rates for gastrectomy with D2 lymphadenectomy than do surgeons in Western countries; however, the disparity remains unexplained. The aim of this article was to determine the feasibility and safety regarding cases in which East Asian surgeons perform such procedures in Caucasian patients (CPs). Twelve CPs underwent gastrectomy with lymphadenectomy for gastric cancer at Yonsei University Severance Hospital, Seoul, Korea between Jun

Pulmonary and Respiratory MedicineMedicine
15
Article|0 citations·2016
When Eastern Surgeons Meet Western Patients: A Pilot Study of Gastrectomy with Lymphadenectomy in Caucasian Patients at a Single Korean Institute
노성훈, Masatoshi Nakagawa, 최윤영, 안지영, 서상혁, 신현백, 방휘재, Shuangxi Li, 김형일, 정재호, 형우진
http://ymj.kr/DOIx.php?id=10.3349/ymj.2016.57.5.1294

East Asian surgeons generally report lower morbidity and mortality rates for gastrectomy with D2 lymphadenectomy than do surgeonsin Western countries; however, the disparity remains unexplained. The aim of this article was to determine the feasibility and safety regarding cases in which East Asian surgeons perform such procedures in Caucasian patients (CPs). Twelve CPs underwentgastrectomy with lymphadenectomy for gastric cancer at Yonsei University Severance Hospital, Seoul, Korea between June

Research Areas

Pulmonary and Respiratory MedicineOncologyPathology and Forensic MedicineCardiology and Cardiovascular MedicineEmergency MedicineImmunology

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