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Hye In Kim

Yonsei University · Engineering

About the Lab

Professor Hye In Kim's research lab specializes in integrative and translational biomedicine, focusing on the health benefits of natural products—particularly Korean red ginseng—and their role in managing age-related conditions in postmenopausal women. The lab investigates the efficacy of herbal remedies, such as red ginseng and soy-hop extracts, in alleviating menopausal symptoms, osteoarthritis, and oxidative stress. It also explores the interplay between body composition (e.g., sarcopenia, obesity) and chronic musculoskeletal conditions, particularly in Korean women. The research combines clinical trials, biochemical assays, and population-based epidemiological studies to evaluate both therapeutic potential and safety of natural interventions.

postmenopausal healthKorean red ginsengsarcopeniaosteoarthritisherbal therapy

Research Overview

Papers
199
Total Citations
1,201
Papers (5y)
29
Primary Field
Engineering

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
29total
2021
2022
2023
2024
2025
Citations per year (5y)
559total
20212022202320242025

Selected Papers

15
1
Article|77 citations·2019
Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 simultaneously alleviate high-fat diet-induced colitis, endotoxemia, liver steatosis, and obesity in mice
Hye In Kim, Jeon-Kyung Kim, Jae‐Young Kim, Se‐Eun Jang, Myung Joo Han, Dong‐Hyun Kim
SJR Q1Nutrition Research
Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
Article|41 citations·2019
Fermented red ginseng and ginsenoside Rd alleviate ovalbumin-induced allergic rhinitis in mice by suppressing IgE, interleukin-4, and interleukin-5 expression
Hye In Kim, Jeon-Kyung Kim, Jae‐Young Kim, Myung Joo Han, Dong‐Hyun Kim
SJR Q1Journal of Ginseng ResearchOA

BACKGROUND: Meyer), RG products modified by heat process or fermentation have been developed. However, the antiallergic effects of RG and modified/fermented RG have not been simultaneously examined. Therefore, we examined the allergic rhinitis (AR)-inhibitory effects of water-extracted RG (wRG), 50% ethanol-extracted RG (eRG), and bifidobacteria-fermented eRG (fRG) in vivo. METHODS: RBL-2H3 cells were stimulated with phorbol 12-myristate-13-acetate/A23187. Mice with AR were prepared by treatment

Molecular BiologyBiochemistry, Genetics and Molecular Biology
3
Article|40 citations·2022
Effects of sarcopenia and sarcopenic obesity on joint pain and degenerative osteoarthritis in postmenopausal women
Hye In Kim, So Hyun Ahn, Yup Kim, Ji Eun Lee, Euna Choi, Seok Kyo Seo
SJR Q1Scientific ReportsOA

Abstract This study aimed to identify the prevalence of sarcopenia, obesity, and sarcopenic obesity and examine their association with radiographic knee osteoarthritis (OA) and knee pain in Korean postmenopausal women. This cross-sectional study utilized the data from Korean National Health and Nutrition Examination Surveys 2009–2011. The participants were categorized into 4 groups based on body composition: either sarcopenic (appendicular skeletal muscle < 23%) or not, either obese (body mas

RheumatologyMedicine
4
Article|22 citations·2020
Characterization of Exome Variants and Their Metabolic Impact in 6,716 American Indians from the Southwest US
Hye In Kim, Bin Ye, Nehal Gosalia, Çiğdem Köroğlu, Robert L. Hanson, Wen‐Chi Hsueh, William C. Knowler, Leslie J. Baier, Clifton Bogardus, Alan R. Shuldiner, Cristopher V. Van Hout
SJR Q1The American Journal of Human GeneticsOA
GeneticsBiochemistry, Genetics and Molecular Biology
5
Article|19 citations·2021
Clinical Effects of Korean Red Ginseng in Postmenopausal Women With Hand Osteoarthritis: A Double-Blind, Randomized Controlled Trial
Hye In Kim, Seung Joo Chon, Ki Eun Seon, Seok Kyo Seo, Yun-Rak Choi
SJR Q1Frontiers in PharmacologyOA

Background: Although many menopausal Asian women use herbal remedies for joint pain, there are no studies evaluating the efficacy of Korean red ginseng on osteoarthritis symptoms in postmenopausal women. The purpose of this study is to analyze antioxidant enzyme activity, oxidative stress markers, and pain scores before and after red ginseng consumption, to assess its effect in postmenopausal women. Methods. This prospective, double-blind, randomized controlled trial enrolled 52 postmenopausal w

Molecular BiologyBiochemistry, Genetics and Molecular Biology
6
Article|16 citations·2021
Ovotesticular Disorder of Sex Development in Korean Children: A Single-Center Analysis over a 30-Year Period
Hye In Kim, Inha Lee, Sang Hwa Kim, Yong Seung Lee, Sang Won Han, Bo Hyon Yun
SJR Q2Journal of Pediatric and Adolescent GynecologyOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
Article|16 citations·2019
Benefits and risks of induction of labor at 39 or more weeks in uncomplicated nulliparous women: a retrospective, observational study
Hye In Kim, Sung Pil Choo, Sang Won Han, Eui Hyeok Kim
SJR Q2Obstetrics & Gynecology ScienceOA

OBJECTIVE: To critically compare the benefits and risks of labor induction versus spontaneous labor in uncomplicated nulliparous women at 39 or more weeks of gestation. METHODS: We conducted a retrospective, observational study of 237 nulliparous women who were at 39 or more weeks of a singleton pregnancy with vertex presentation and intact membranes. We compared maternal outcomes including the Cesarean section rate and neonatal outcomes in the induced labor and spontaneous labor groups. RESULTS

Obstetrics and GynecologyMedicine
8
Article|12 citations·2021
Efficacy and Safety of a Standardized Soy and Hop Extract on Menopausal Symptoms: A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Hye In Kim, Min Kyoung Kim, Inha Lee, Jisun Yun, Eui Hyeok Kim, Seok Kyo Seo
The Journal of Alternative and Complementary MedicineOA

Objectives: Soy and hop extracts have been investigated as alternatives for hormone replacement therapy. However, their combined efficacy is not known. We investigated the efficacy and safety of a combined soy and hop extract on postmenopausal symptoms. Design: Double-blinded, randomized controlled trial. Settings/Location: Gynecological outpatient clinic of tertiary hospital. Subjects: Seventy-eight women with moderate or severe menopausal symptoms assessed as modified Kupperman Menopoausal Ind

PharmacologyPharmacology, Toxicology and Pharmaceutics
9
Preprint|10 citations·2021
Effects of Sarcopenia and Sarcopenic Obesity on Joint Pain and Degenerative Osteoarthritis in Postmenopausal Women
Hye In Kim, So Hyun Ahn, Yup Kim, Ji Eun Lee, Seok Kyo Seo
Research SquareOA

Abstract This study aimed to identify the prevalence of sarcopenia, obesity, and sarcopenic obesity and examine their association with radiographic knee osteoarthritis (OA) and knee pain in Korean menopausal women. This cross-sectional study utilized the data from Korean National Health and Nutrition Examination Surveys 2009–2011. The participants were categorized based on body composition. The prevalence of radiographic knee OA and knee pain was calculated. The effect of hormone therapy (HT) wa

RheumatologyMedicine
10
Article|10 citations·2016
Myasthenia Crisis Induced by Pegylated-Interferon in Patient With Chronic Hepatitis C
Su Jung Baik, Tae Hun Kim, Hye In Kim, Jeong Yeon Rhie
SJR Q3MedicineOA

Myasthenia gravis is occasionally associated with thymoma that needs surgical resection and may progress to severe respiratory failure. We experienced a rare case of myasthenia crisis during antiviral therapy for chronic hepatitis C, in whom mediastinal thymoma was discovered and successfully managed with surgical thymectomy and meticulous medical care.A 47-year-old-male patient complained of sudden diplopia 1 week after stopping 11-week administration of pegylated-interferon and ribavirin for c

NeurologyMedicine
11
Article|9 citations·2019
Cesarean section does not increase the prevalence of allergic disease within 3 years of age in the offsprings
Hye In Kim, SeonMi Nam, Yejin Park, Yun Ji Jung, Ha Yan Kim, Kyung Won Kim, Myung Hyun Sohn, Young Han Kim, Joon-Ho Lee, Soo‐Jong Hong, Ja‐Young Kwon
SJR Q2Obstetrics & Gynecology ScienceOA

Cesarean section, irrespective of the occurrence of labor before surgery, did not increase the prevalence of allergic disease in infants up to 3 years of age.

Pulmonary and Respiratory MedicineMedicine
12
Article|9 citations·2021
Changes in the Expression of TBP-2 in Response to Histone Deacetylase Inhibitor Treatment in Human Endometrial Cells
Hye In Kim, Seok Kyo Seo, Seung Joo Chon, Ga Hee Kim, Inha Lee, Bo Hyon Yun
SJR Q1International Journal of Molecular SciencesOA

Histone deacetylase inhibitors (HDACi) induce apoptosis preferentially in cancer cells by caspase pathway activation and reactive oxygen species (ROS) accumulation. Suberoylanilide hydroxamic acid (SAHA), a HDACi, increases apoptosis via altering intracellular oxidative stress through thioredoxin (TRX) and TRX binding protein-2 (TBP-2). Because ROS accumulation, as well as the redox status determined by TBP-2 and TRX, are suggested as possible mechanisms for endometriosis, we queried whether SAH

Reproductive MedicineMedicine
13
Article|8 citations·2013
Association of adherence to the seventh report of the Joint National Committee guidelines with hypertension in Korean men and women
Hye In Kim, YoonJu Song, Woo‐Young Kim, Jung Eun Lee
SJR Q1Nutrition Research
Public Health, Environmental and Occupational HealthMedicine
14
Article|6 citations·2022
Identification of Single Nucleotide Polymorphisms as Biomarkers for Recurrent Pregnancy Loss in Korean Women
Hye In Kim, Eun A. Choi, Eun Chan Paik, Soo-Hyeon Park, Yu Im Hwang, Jae Hoon Lee, Seok Kyo Seo, SiHyun Cho, Young Sik Choi, Byung Seok Lee, Jimyeong Park, Sanghoo Lee
SJR Q2Journal of Korean Medical ScienceOA

There is a significant association between the risk of RPL and miR-449b/TNF-α combination, and therefore, genetic analysis for specific combined genotypes can be an important screening method for RPL in Korean women.

ImmunologyImmunology and Microbiology
15
Article|6 citations·2023
FSLLRY-NH2, a protease-activated receptor 2 (PAR2) antagonist, activates mas-related G protein-coupled receptor C11 (MrgprC11) to induce scratching behaviors in mice
Hye In Kim, Gi Baek Lee, Da Eun Song, Babina Sanjel, Wook‐Joo Lee, Won‐Sik Shim
SJR Q1Life Sciences
Cell BiologyBiochemistry, Genetics and Molecular Biology

Research Areas

Aerospace EngineeringMolecular BiologyGeneticsReproductive MedicineCivil and Structural EngineeringPublic Health, Environmental and Occupational Health

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