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Hye Jin Yoon

Yonsei University · Medicine

About the Lab

Professor Hye Jin Yoon's research lab focuses on biomedical and structural virology, with a strong emphasis on HIV pathogenesis, host-pathogen interactions, and metabolic liver diseases. The lab develops innovative bioinformatics tools such as CATNAP and PrimerDesign-M to analyze viral genetic diversity and optimize experimental primer design for long-genome amplification. It also investigates the molecular mechanisms of bacterial pathogens like *Helicobacter pylori*, particularly in relation to cell morphology and virulence. Additionally, the lab explores metabolic disorders, including non-alcoholic fatty liver disease and type 2 diabetes, with a focus on biomarkers and disease progression.

HIVneutralizing antibodiesmetabolic liver diseasebacterial pathogenesisprimer design

Research Overview

Papers
131
Total Citations
7,878
Papers (5y)
23
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
23total
2022
2023
2024
2025
2026
Citations per year (5y)
254total
20222023202420252026

Selected Papers

15
1
Article|181 citations·2015
CATNAP: a tool to compile, analyze and tally neutralizing antibody panels
Hyejin Yoon, Jennifer P. Macke, Anthony P. West, Brian Foley, Pamela J. Björkman, Bette Korber, Karina Yusim
SJR Q1Nucleic Acids ResearchOA

CATNAP (Compile, Analyze and Tally NAb Panels) is a new web server at Los Alamos HIV Database, created to respond to the newest advances in HIV neutralizing antibody research. It is a comprehensive platform focusing on neutralizing antibody potencies in conjunction with viral sequences. CATNAP integrates neutralization and sequence data from published studies, and allows users to analyze that data for each HIV Envelope protein sequence position and each antibody. The tool has multiple data retri

VirologyImmunology and Microbiology
2
Review|76 citations·2014
Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease
Hyejin Yoon
SJR Q2World Journal of HepatologyOA

Non-alcoholic fatty liver disease affects approximately one-third of the population worldwide, and its incidence continues to increase with the increasing prevalence of other metabolic disorders such as type 2 diabetes. As non-alcoholic fatty liver disease can progress to liver cirrhosis, its treatment is attracting greater attention. The pathogenesis of non-alcoholic fatty liver disease is closely associated with insulin resistance and dyslipidemia, especially hypertriglyceridemia. Increased se

EpidemiologyMedicine
3
Article|66 citations·2014
PrimerDesign-M: a multiple-alignment based multiple-primer design tool for walking across variable genomes
Hyejin Yoon, Thomas Leitner
SJR Q1BioinformaticsOA

SUMMARY: Analyses of entire viral genomes or mtDNA requires comprehensive design of many primers across their genomes. Furthermore, simultaneous optimization of several DNA primer design criteria may improve overall experimental efficiency and downstream bioinformatic processing. To achieve these goals, we developed PrimerDesign-M. It includes several options for multiple-primer design, allowing researchers to efficiently design walking primers that cover long DNA targets, such as entire HIV-1 g

Plant ScienceAgricultural and Biological Sciences
4
Article|36 citations·2013
Aminopropyl carbazole analogues as potent enhancers of neurogenesis
Hye Jin Yoon, Sun-Young Kong, Min-Hye Park, Yongsung Cho, Sung‐Eun Kim, Jae-Yeon Shin, Sunghye Jung, Jiyoun Lee, Jiyoun Lee, Farhanullah, Hyun‐Jung Kim, Jeewoo Lee
SJR Q2Bioorganic & Medicinal Chemistry
Developmental NeuroscienceNeuroscience
5
Article|35 citations·2015
The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of l,d-Carboxypeptidase
Hyoun Sook Kim, Ha Na Im, Doo Ri An, Ji Yoon, Jun Young Jang, Shahriar Mobashery, Dušan Hesek, Mijoon Lee, Jakyung Yoo, Minghua Cui, Sun Choi, Cheol‐Hee Kim
SJR Q1Journal of Biological ChemistryOA

Helicobacter pylori causes gastrointestinal diseases, including gastric cancer. Its high motility in the viscous gastric mucosa facilitates colonization of the human stomach and depends on the helical cell shape and the flagella. In H. pylori, Csd6 is one of the cell shape-determining proteins that play key roles in alteration of cross-linking or by trimming of peptidoglycan muropeptides. Csd6 is also involved in deglycosylation of the flagellar protein FlaA. To better understand its function, b

OncologyMedicine
6
Article|30 citations·2013
Analysis of clinical outcomes with respect to spermatozoan origin after artificial oocyte activation with a calcium ionophore
Hye Jin Yoon, In Hee Bae, Hyoung Jun Kim, Jung Mi Jang, Yong Su Hur, Hae Kwon Kim, San Hyun Yoon, Won Don Lee, Jin Ho Lim
SJR Q1Journal of Assisted Reproduction and Genetics
Reproductive MedicineMedicine
7
Article|30 citations·2012
Correlations between Glucagon Stimulated C-peptide Levels and Microvascular Complications in Type 2 Diabetes Patients
Hyejin Yoon, Youn-Zoo Cho, Jiyoung Kim, Byung-Joon Kim, Keun‐Young Park, Gwanpyo Koh, Dae-Ho Lee, Dong-Mee Lim
SJR Q1Diabetes & Metabolism JournalOA

BACKGROUND: This study aimed to investigate whether stimulated C-peptide is associated with microvascular complications in type 2 diabetes mellitus (DM). METHODS: A cross-sectional study was conducted in 192 type 2 diabetic patients. Plasma basal C-peptide and stimulated C-peptide were measured before and 6 minutes after intravenous injection of 1 mg glucagon. The relationship between C-peptide and microvascular complications was statistically analyzed. RESULTS: In patients with retinopathy, bas

GeneticsBiochemistry, Genetics and Molecular Biology
8
Article|2 citations·2002
The survival and fertilization of human MII-stage oocytes cryopreserved by vitrification
Hye Jin Yoon, Jeong Hee Moon, Weon‐Young Son, Seokwon Lee, San-Hyun Yoon, Jin‐Ho Lim
SJR Q1Fertility and Sterility
Public Health, Environmental and Occupational HealthMedicine
9
erratum|2 citations·2013
Corrigendum to “Aminopropyl carbazole analogues as potent enhancers of neurogenesis” [Bioorg. Med. Chem. 21 (2013) 7165–7174]
Hye Jin Yoon, Sun-Young Kong, Min-Hye Park, Yongsung Cho, Sung‐Eun Kim, Jae-Yeon Shin, Sunghye Jung, Jiyoun Lee, Jiyoun Lee, Farhanullah, Hyun‐Jung Kim, Jeewoo Lee
SJR Q2Bioorganic & Medicinal Chemistry
PharmacologyMedicine
10
Article|2 citations·2022
딥러닝에 기반한 전통성의 비율별 한옥카페 디자인 가이드라인
윤혜진, 이현수
한국실내디자인학회 논문집

This paper presents a direction that can be used as a reference for design by classifying images according to the ratio of traditionality of spaces that appear in hanok cafes. With the development of the times, the traditional hanok, which felt uncomfortable, was recklessly repaired and remodeled without standards to create a space suitable for the times. Therefore, in this paper, for the universalization of hanok in the modern era, the purpose of this paper is to examine the architectural eleme

11
Article|2 citations·2018
Exploring the Motivation and Meaning of Hanbok Experience in Cultural Heritage Sites
Hyejin Yoon
Journal & Article Management System
Information SystemsComputer Science
12
Article|2 citations·2000
The Case of Esophageal Foreign Body with Esophageal Perforation and Paraesophageal Abscess
Hye Jin Yoon
Journal of Clinical Otolaryngology Head and Neck SurgeryOA

The main point in managing suspected impaction of esophageal foreign bodies is to decide whether the patient needs an esophageal endoscopy. Esophageal perforation caused by foreign body is caused by pressure necrosis with progressive breakdown of the esophageal wall and migration of the object into the pleural cavity or even into the major vessel. We experienced a case of esophageal foreign body which penetrated the cervical esophagus and formed periesophageal abscess. It was successfully remove

Radiology, Nuclear Medicine and ImagingMedicine
13
Article|2 citations·2014
An effective method for improving outcomes in patients with a fertilization defect
Hye Jin Yoon, Hyung Jun Kim, In Hee Bae, Soo Jin Chae, San Hyun Yoon, Won Don Lee, Jin Ho Lim
SJR Q3Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicineOA

The effect of artificial oocyte activation (AOA) with a calcium ionophore on intracytoplasmic morphologically selected sperm injection (IMSI) was examined in patients with histories of repeated failed implantation attempts. Four singleton pregnancies and one twin pregnancy were obtained after embryos transfer (5/14, 35.7%). Therefore, AOA combined with IMSI can be considered an option for cycles with a fertilization defect and recurrent implantation failures.

Public Health, Environmental and Occupational HealthMedicine
14
Article|1 citations·2020
육군 초급간부의 군 정신건강 서비스 이용 실태
윤혜진, 김고운, 김선아

Purpose: The purpose of this survey is to examine military mental health service use of junior army officers. Methods: The study included 381 Army officers serving for the army less then 5 years and working for the Army infantry division. A self-reported online survey was used to assess general characteristics, military mental health service use, satisfaction, and needs. Results: The military mental health service use of junior army officers was low. but their satisfaction was high. The needs on

15
Article|0 citations·2015
Glycated albumin and the risk of micro- and macrovascular complications in subjects with type 1 diabetes
Hyejin Yoon, Yong‐ho Lee, So Ra Kim, Tyler Hyungtaek Rim, Eun Lee, Eun Seok Kang, Bong Soo, Hyun Chul Lee, Byung‐Wan Lee

Background We investigated the relationship between the glycemic indices glycated albumin (GA) and glycated hemoglobin (HbA1c) and the progression of diabetic vascular complications [diabetic nephropathy (DN) and carotid artery atherosclerosis (CAA)] in subjects with type 1 diabetes (T1D).

Endocrinology, Diabetes and MetabolismMedicine

Research Areas

Molecular BiologyInfectious DiseasesOncologyVirologyPublic Health, Environmental and Occupational HealthNeurology

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