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Hyeonseok Jang

Korea University · Medicine

About the Lab

Professor Hyeonseok Jang's research lab specializes in regenerative medicine and biomedical engineering, with a focus on tissue engineering, stem cell differentiation, and biomaterials development for oral and maxillofacial applications. The lab investigates osteogenic differentiation using growth factors like BMP-2, develops advanced delivery systems for sustained bioactivity, and explores the role of microbiota in enhancing the efficacy of natural therapeutics such as probiotic-fermented red ginseng. Additionally, the lab applies advanced imaging techniques, including 3D volumetric CT analysis, to evaluate the outcomes of surgical interventions such as jaw cyst decompression.

tissue engineeringBMP-2 deliverystem cell differentiationregenerative medicineoral surgery

Research Overview

Papers
73
Total Citations
726
Papers (5y)
13
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
13total
2019
2020
2021
2022
2025
Citations per year (5y)
175total
20192020202120222025

Selected Papers

15
1
Article|120 citations·2005
Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells
Hyon-Seok Jang, Sung-Ho Kook, Young‐Ok Son, Jong-Ghee Kim, Young-Mi Jeon, Yong-Suk Jang, Ki-Choon Choi, Ju Kim, Seong-Kyu Han, Kyung-Yeol Lee, Byung-Keon Park, Nam‐Pyo Cho
SJR Q2Biochimica et Biophysica Acta (BBA) - General Subjects
Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
Article|97 citations·2004
Selective antiproliferative and apoptotic effects of flavonoids purified from Rhus verniciflua Stokes on normal versus transformed hepatic cell lines
Young‐Ok Son, Kyung-Yeol Lee, Jeong-Chae Lee, Hyon-Seok Jang, Jong-Ghee Kim, Young-Mi Jeon, Yong-Suk Jang
SJR Q2Toxicology Letters
Endocrinology, Diabetes and MetabolismMedicine
3
Article|57 citations·2003
Induction of antigen-specific systemic and mucosal immune responses by feeding animals transgenic plants expressing the antigen
Jong-Lye Bae, Jong-Gul Lee, Tae-Jin Kang, Hyon-Seok Jang, Yong-Suk Jang, Moon-Sik Yang
SJR Q1Vaccine
BiotechnologyBiochemistry, Genetics and Molecular Biology
4
Review|54 citations·2019
A review of complications of maxillary sinus augmentation and available treatment methods
Joongmin Kim, Hyon-Seok Jang
SJR Q2Journal of the Korean Association of Oral and Maxillofacial SurgeonsOA

Maxillary sinus grafting is a dependable procedure that has been in use for a long time. However, clinical complications often arise. To prevent complications of maxillary sinus grafting, it is necessary to know the contra-indications, both for general implantation and for maxillary bone grafting. In addition, presence of various complications requires careful consideration of treatment method; therefore, dentists should be familiar with the treatment protocols. Complications can be divided into

Oral SurgeryDentistry
5
Article|39 citations·2017
Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells
Taek‐Hee Jung, John Hwan Lee, Soon‐Jung Park, Yong-Jin Kim, Joseph Seo, Hye-Eun Shim, Ki-Suk Kim, Hyon-Seok Jang, Hyung‐Min Chung, Seong-Geun Oh, Sung-Hwan Moon, Sun-Woong Kang
SJR Q2Stem Cells InternationalOA

Differentiation of stem cells is an important strategy for regeneration of defective tissue in stem cell therapy. Bone morphogenetic protein-2 (BMP-2) is a well-known osteogenic differentiation factor that stimulates stem cell signaling pathways by activating transmembrane type I and type II receptors. However, BMPs have a very short half-life and may rapidly lose their bioactivity. Thus, a BMP delivery system is required to take advantage of an osteoinductive effect for osteogenic differentiati

Biomedical EngineeringEngineering
6
Article|36 citations·2012
Combination therapy with BMP-2 and BMSCs enhances bone healing efficacy of PCL scaffold fabricated using the 3D plotting system in a large segmental defect model
Sun‐Woong Kang, Ji‐Hoon Bae, Su-A Park, Wan-Doo Kim, Mi-Su Park, Y T Ko, Hyon-Seok Jang, Jung Ho Park
SJR Q2Biotechnology Letters
Biomedical EngineeringEngineering
7
Article|29 citations·2016
Red ginseng powder fermented with probiotics exerts antidiabetic effects in the streptozotocin-induced mouse diabetes model
Sun-Hee Jang, Jisang Park, Sae‐Hae Kim, Kyung-Min Choi, Eun-Sil Ko, Jeong‐Dan Cha, Young‐Ran Lee, Hyon-Seok Jang, Yong-Suk Jang
SJR Q1Pharmaceutical BiologyOA

CONTEXT: Red ginseng (heat-processed Panax ginseng) is a well-known alternative medicine with pharmacological antidiabetic activity. It exerts pharmacological effects through the transformation of saponin into metabolites by the intestinal microbiota. Given that intestinal conditions and intestinal microflora vary among individuals, the pharmacological effects of orally administered red ginseng likely may vary among individuals. OBJECTIVE: To overcome this variation and produce homogeneously eff

Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
Article|24 citations·2020
Effect of Decompression on Jaw Cystic Lesions Based on Three-Dimensional Volumetric Analysis
Yeh-Jin Kwon, Kyeong-Soo Ko, Byung-Kyu So, Dong-Hyuck Kim, Hyon-Seok Jang, Soo‐Ho Kim, Eui‐Seok Lee, Ho‐Kyung Lim
SJR Q2MedicinaOA

Background and objectives: This study aimed to evaluate the effectiveness of decompression on jaw cysts according to various parameters by volumetric analysis using three-dimensional computed tomography. Materials and methods: Fifty patients who underwent surgical decompression of the jaw cystic lesion were selected, and their preoperative and postoperative computed tomography results between 3 and 27 months were collected. Volumetric analysis was performed to evaluate any differences in the rat

Oral SurgeryDentistry
9
Article|24 citations·2020
Combined Delivery of Two Different Bioactive Factors Incorporated in Hydroxyapatite Microcarrier for Bone Regeneration
Tae‐Woo Kim, Woo-Beom Ahn, Joong-Min Kim, Joong-Hyun Kim, Tae-Hyun Kim, Román A. Pérez, Hyon-Seok Jang
SJR Q1Tissue Engineering and Regenerative MedicineOA
Biomedical EngineeringEngineering
10
Article|21 citations·2016
Demineralized dentin matrix combined with recombinant human bone morphogenetic protein-2 in rabbit calvarial defects
In‐Woong Um, Suk-Hyun Hwang, Young‐Kyun Kim, Moon Young Kim, Sang-Ho Jun, Jae‐Jun Ryu, Hyon-Seok Jang
SJR Q2Journal of the Korean Association of Oral and Maxillofacial SurgeonsOA

Within the limitations of this study, DDM appears to be a suitable carrier for rhBMP-2 in orthotopic sites.

Biomedical EngineeringEngineering
11
Article|21 citations·2017
Oral administration of red ginseng powder fermented with probiotic alleviates the severity of dextran-sulfate sodium-induced colitis in a mouse model
Sun‐Hee Jang, Jisang Park, Sae‐Hae Kim, Kyung-Min Choi, Eun-Sil Ko, Jeong‐Dan Cha, Young-Ran Lee, Hyon-Seok Jang, Yong‐Suk Jang
SJR Q1Chinese Journal of Natural Medicines
Molecular BiologyBiochemistry, Genetics and Molecular Biology
12
Article|21 citations·2001
DNA-mediated Immunization of Glycoprotein 350 of Epstein-Barr Virus Induces the Effective Humoral and Cellular Immune Responses Against the Antigen
Sojin Jung, Young-Kwan Chung, Sun-Hwa Chang, Ju Kim, Hak-Ryul Kim, Hyon-Seok Jang, Jeong‐Chae Lee, Gook-Hyun Chung, Yong‐Suk Jang
SJR Q1Molecules and CellsOA

Epstein-Barr virus (EBV) is a human pathogen that is involved in numerous diseases and tumors. Since the EBV infection occurs in the early ages of life, and most of the population is subsequently exposed to EBV, the conventional method of vaccination to induce the prophylactic immunity cannot be considered effective in coping with the virus infection. In this study, we tested whether the injection of a plasmid vector that contained the gene for glycoprotein 350 (gp350), which had been identified

OncologyMedicine
13
Article|21 citations·2015
Combination of nanoparticles with photothermal effects and phase-change material enhances the non-invasive transdermal delivery of drugs
Yong Jin Kim, Bongsoo Kim, Jin Woong Kim, Gaewon Nam, Hyon-Seok Jang, Sun‐Woong Kang, Unyong Jeong
SJR Q1Colloids and Surfaces B Biointerfaces
Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics
14
Article|20 citations·2022
Decellularized Human Adipose Tissue as an Alternative Graft Material for Bone Regeneration
Woo Beom Ahn, Yu Bin Lee, Yi‐Hwa Ji, Kyoung‐Sik Moon, Hyon-Seok Jang, Sun‐Woong Kang
SJR Q1Tissue Engineering and Regenerative MedicineOA
SurgeryMedicine
15
Article|18 citations·2018
The influence of bone graft procedures on primary stability and bone change of implants placed in fresh extraction sockets
Sang-Ho Jun, Chang‐Joo Park, Suk-Hyun Hwang, Youn Ki Lee, Cong Zhou, Hyon-Seok Jang, Jae‐Jun Ryu
SJR Q2Maxillofacial Plastic and Reconstructive SurgeryOA

This study was to evaluate the effect of bone graft procedure on the primary stability of implants installed in fresh sockets and assess the vertical alteration of peri-implant bone radiographically. Twenty-three implants were inserted in 18 patients immediately after tooth extraction. The horizontal gap between the implant and bony walls of the extraction socket was grafted with xenografts. The implant stability before and after graft procedure was measured by Osstell Mentor as implant stabilit

Oral SurgeryDentistry

Research Areas

Oral SurgeryBiomedical EngineeringMolecular BiologyUrologyGeneticsSurgery

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